1T3T
Structure of Formylglycinamide synthetase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004642 | molecular_function | phosphoribosylformylglycinamidine synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 2006 |
| Chain | Residue |
| A | ASP679 |
| A | ASN722 |
| A | ASP884 |
| A | ADP2005 |
| A | HOH3086 |
| A | HOH3089 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 2007 |
| Chain | Residue |
| A | HOH2054 |
| A | HOH3090 |
| A | HOH3091 |
| A | GLU718 |
| A | ADP2005 |
| A | HOH2023 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 2008 |
| Chain | Residue |
| A | ADP2005 |
| A | HOH2041 |
| A | HOH3085 |
| A | HOH3087 |
| A | HOH3088 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2001 |
| Chain | Residue |
| A | HIS216 |
| A | GLU294 |
| A | GLY504 |
| A | ALA505 |
| A | LYS776 |
| A | HOH2608 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2002 |
| Chain | Residue |
| A | HIS216 |
| A | THR295 |
| A | HIS296 |
| A | ASN297 |
| A | HIS298 |
| A | SER778 |
| A | HOH2261 |
| A | HOH2269 |
| A | HOH2362 |
| A | HOH2733 |
| A | HOH2914 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2009 |
| Chain | Residue |
| A | TYR690 |
| A | ARG812 |
| A | LYS1228 |
| A | VAL1229 |
| A | HOH2066 |
| A | HOH2527 |
| A | HOH2765 |
| A | HOH2963 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2010 |
| Chain | Residue |
| A | GLN1176 |
| A | GLN1183 |
| A | GLY1184 |
| A | MET1185 |
| A | VAL1186 |
| A | HOH2245 |
| A | HOH2252 |
| A | HOH2785 |
| A | HOH3012 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2011 |
| Chain | Residue |
| A | PRO1040 |
| A | LYS1041 |
| A | HIS1086 |
| A | HOH2274 |
| A | HOH2415 |
| A | HOH2621 |
| A | HOH2704 |
| A | HOH2836 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2012 |
| Chain | Residue |
| A | HIS1086 |
| A | ARG1126 |
| A | PRO1127 |
| A | GLN1128 |
| A | THR1129 |
| A | HOH2244 |
| A | HOH2250 |
| A | HOH2792 |
| A | HOH2974 |
| site_id | BC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE ADP A 2005 |
| Chain | Residue |
| A | THR386 |
| A | GLY387 |
| A | TYR388 |
| A | PHE389 |
| A | LEU652 |
| A | GLN668 |
| A | PRO676 |
| A | ALA678 |
| A | ASP679 |
| A | GLU718 |
| A | ASN722 |
| A | SER886 |
| A | MG2006 |
| A | MG2007 |
| A | MG2008 |
| A | HOH2023 |
| A | HOH2041 |
| A | HOH2061 |
| A | HOH2093 |
| A | HOH2140 |
| A | HOH2156 |
| A | HOH2265 |
| A | HOH2381 |
| A | HOH2682 |
| A | HOH3090 |
| A | HOH3091 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15301531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24223728","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
