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1SZS

The structure of gamma-aminobutyrate aminotransferase mutant: I50Q

Functional Information from GO Data
ChainGOidnamespacecontents
A0003867molecular_function4-aminobutyrate transaminase activity
A0003992molecular_functionN2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A0005829cellular_componentcytosol
A0008483molecular_functiontransaminase activity
A0009448biological_processgamma-aminobutyric acid metabolic process
A0009450biological_processgamma-aminobutyric acid catabolic process
A0030170molecular_functionpyridoxal phosphate binding
A0034386molecular_function4-aminobutyrate:2-oxoglutarate transaminase activity
A0042450biological_processarginine biosynthetic process via ornithine
A0042803molecular_functionprotein homodimerization activity
A0047589molecular_function5-aminovalerate transaminase activity
B0003867molecular_function4-aminobutyrate transaminase activity
B0003992molecular_functionN2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B0005829cellular_componentcytosol
B0008483molecular_functiontransaminase activity
B0009448biological_processgamma-aminobutyric acid metabolic process
B0009450biological_processgamma-aminobutyric acid catabolic process
B0030170molecular_functionpyridoxal phosphate binding
B0034386molecular_function4-aminobutyrate:2-oxoglutarate transaminase activity
B0042450biological_processarginine biosynthetic process via ornithine
B0042803molecular_functionprotein homodimerization activity
B0047589molecular_function5-aminovalerate transaminase activity
C0003867molecular_function4-aminobutyrate transaminase activity
C0003992molecular_functionN2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0005829cellular_componentcytosol
C0008483molecular_functiontransaminase activity
C0009448biological_processgamma-aminobutyric acid metabolic process
C0009450biological_processgamma-aminobutyric acid catabolic process
C0030170molecular_functionpyridoxal phosphate binding
C0034386molecular_function4-aminobutyrate:2-oxoglutarate transaminase activity
C0042450biological_processarginine biosynthetic process via ornithine
C0042803molecular_functionprotein homodimerization activity
C0047589molecular_function5-aminovalerate transaminase activity
D0003867molecular_function4-aminobutyrate transaminase activity
D0003992molecular_functionN2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0005829cellular_componentcytosol
D0008483molecular_functiontransaminase activity
D0009448biological_processgamma-aminobutyric acid metabolic process
D0009450biological_processgamma-aminobutyric acid catabolic process
D0030170molecular_functionpyridoxal phosphate binding
D0034386molecular_function4-aminobutyrate:2-oxoglutarate transaminase activity
D0042450biological_processarginine biosynthetic process via ornithine
D0042803molecular_functionprotein homodimerization activity
D0047589molecular_function5-aminovalerate transaminase activity
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1201
ChainResidue
AILE184
AHIS188
AARG224

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1202
ChainResidue
BLYS5
BARG381
BHOH1430
BHOH1507

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 1203
ChainResidue
BARG224
BHOH1429
BHOH1525
BILE184
BHIS188

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 C 1204
ChainResidue
CHIS188
CARG224
CHOH1513

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 D 1205
ChainResidue
DHIS188
DARG224

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 1206
ChainResidue
BHOH1446
DLYS5
DARG381
DHOH1347

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1207
ChainResidue
ALYS151
AASN153
ATYR394
AHOH1326
CLYS192

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1208
ChainResidue
BLYS151
BASN153
BTYR394
DLYS192

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 D 1209
ChainResidue
BLYS192
DLYS151
DASN153
DTYR394
DHOH1523

site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 C 1210
ChainResidue
ALYS192
AHOH1361
CLYS151
CASN153
CTYR394

site_idBC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 D 1211
ChainResidue
AGLN419
AHOH1477
CLYS71
CHOH1385
DARG29
DHOH1399
DHOH1534

site_idBC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 1212
ChainResidue
AGLN50
ATYR138
AARG141
AHOH1351
AHOH1458
AHOH1548
BCYS77
BGLN79
BGLY296

site_idBC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE SO4 A 1213
ChainResidue
ACYS77
AGLN79
AGLY295
AGLY296
AHOH1448
BGLN50
BTYR138
BARG141
BHOH1273
BHOH1568
BHOH1569

site_idBC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE SO4 D 1214
ChainResidue
CGLN50
CARG141
CEDO1230
CHOH1287
CHOH1527
DCYS77
DGLN79
DGLY295
DGLY296
DHOH1315
DHOH1559

site_idBC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 C 1215
ChainResidue
CGLN79
CGLY296
DGLN50
DARG141
DHOH1305
DHOH1432

site_idBC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO B 1216
ChainResidue
ATHR76
AVAL80
ALEU81
BASP45
BALA47
BGLY48
BGLY49
BHIS57

site_idBC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO B 1217
ChainResidue
BILE22
BHIS23
BARG381
BHOH1404

site_idBC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE EDO A 1218
ChainResidue
ATYR167
AHOH1507
CGLY164
CHIS165
CVAL166
CTYR167
CHOH1484
AGLY164
AHIS165
AVAL166

site_idCC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE EDO B 1219
ChainResidue
BGLY164
BHIS165
BVAL166
BTYR167
BHOH1472
DGLY164
DHIS165
DVAL166
DTYR167

site_idCC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO D 1220
ChainResidue
CTHR76
CVAL80
DASP45
DALA47
DGLY48
DGLY49
DHIS57

site_idCC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO D 1221
ChainResidue
CPRO275
CASN301
DPRO275
DASN301

site_idCC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO D 1222
ChainResidue
DILE22
DHIS23
DPRO24
DARG381

site_idCC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO A 1223
ChainResidue
AASP45
AALA47
AGLY48
AGLY49
AHIS57
BTHR76
BVAL80
BLEU81

site_idCC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO C 1224
ChainResidue
CASP45
CALA47
CGLY48
CGLY49
CHIS57
DTHR76
DVAL80
DLEU81

site_idCC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1225
ChainResidue
AGLN69
APRO85
BALA27
BASP28

site_idCC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO C 1226
ChainResidue
CGLN69
CLYS72
CLEU73
CPRO85
CHOH1444
DASP28
DHOH1389

site_idCC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO D 1227
ChainResidue
BTYR167
DTYR167
DARG168
DHOH1403
DHOH1465

site_idDC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1228
ChainResidue
AGLN9
DLYS96
DPRO98
DGLU255

site_idDC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO B 1229
ChainResidue
BTYR155
BGLU211
BARG398
BHOH1501
BHOH1568
BHOH1570

site_idDC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO C 1230
ChainResidue
CGLN50
CGLU211
CGLN242
CARG398
CHOH1527
DSO41214
DHOH1559

site_idDC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO D 1231
ChainResidue
DGLN50
DGLU211
DGLN242
DLYS268
DARG398
DPMP1274
DHOH1432
DHOH1560

site_idDC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 1232
ChainResidue
AGLN50
AGLU211
AGLN242
AARG398
APMP1271
AHOH1458

site_idDC6
Number of Residues16
DetailsBINDING SITE FOR RESIDUE PLP A 1261
ChainResidue
AGLY111
ASER112
ATYR138
AHIS139
AGLU206
AASP239
AVAL241
AGLN242
ALYS268
AHOH1273
AHOH1277
AHOH1281
AHOH1351
AHOH1378
BTHR297
BHOH1343

site_idDC7
Number of Residues17
DetailsBINDING SITE FOR RESIDUE PLP B 1262
ChainResidue
ATHR297
AHOH1315
BTHR110
BGLY111
BSER112
BTYR138
BHIS139
BGLU206
BASP239
BVAL241
BGLN242
BLYS268
BHOH1273
BHOH1280
BHOH1288
BHOH1318
BHOH1382

site_idDC8
Number of Residues16
DetailsBINDING SITE FOR RESIDUE PLP C 1263
ChainResidue
CGLY111
CSER112
CTYR138
CHIS139
CGLU206
CASP239
CVAL241
CGLN242
CLYS268
CHOH1287
CHOH1290
CHOH1293
CHOH1306
CHOH1331
CHOH1496
DTHR297

site_idDC9
Number of Residues16
DetailsBINDING SITE FOR RESIDUE PLP D 1264
ChainResidue
CTHR297
CHOH1291
DGLY111
DSER112
DTYR138
DHIS139
DGLU206
DASP239
DVAL241
DGLN242
DLYS268
DHOH1275
DHOH1285
DHOH1288
DHOH1305
DHOH1311

site_idEC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE PMP A 1271
ChainResidue
AGLN50
ATHR110
AGLY111
ASER112
ATYR138
AHIS139
AGLU206
AASP239
AVAL241
AGLN242
ALYS268
AEDO1232
AHOH1273
AHOH1277
AHOH1281
AHOH1351
BTHR297
BHOH1343

site_idEC2
Number of Residues19
DetailsBINDING SITE FOR RESIDUE PMP B 1272
ChainResidue
ATHR297
AHOH1315
BGLN50
BTHR110
BGLY111
BSER112
BTYR138
BHIS139
BGLU206
BASP239
BVAL241
BGLN242
BLYS268
BHOH1273
BHOH1280
BHOH1288
BHOH1318
BHOH1382
BHOH1569

site_idEC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE PMP C 1273
ChainResidue
CTHR110
CGLY111
CSER112
CTYR138
CHIS139
CGLU206
CASP239
CVAL241
CGLN242
CLYS268
CHOH1287
CHOH1290
CHOH1293
CHOH1306
CHOH1331
CHOH1496
DTHR297
DHOH1559

site_idEC4
Number of Residues20
DetailsBINDING SITE FOR RESIDUE PMP D 1274
ChainResidue
CTHR297
CHOH1291
DGLN50
DTHR110
DGLY111
DSER112
DTYR138
DHIS139
DGLU206
DASP239
DVAL241
DGLN242
DLYS268
DEDO1231
DHOH1275
DHOH1285
DHOH1288
DHOH1305
DHOH1311
DHOH1563

Functional Information from PROSITE/UniProt
site_idPS00600
Number of Residues38
DetailsAA_TRANSFER_CLASS_3 Aminotransferases class-III pyridoxal-phosphate attachment site. LIaDEVqsgAG.RtGtlfameqmgvap....DLTtfAKsiaGG
ChainResidueDetails
ALEU236-GLY273

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:15323550, ECO:0000269|PubMed:15723541
ChainResidueDetails
AGLY111
DGLY111
DGLN242
DTHR297
AGLN242
ATHR297
BGLY111
BGLN242
BTHR297
CGLY111
CGLN242
CTHR297

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:15323550, ECO:0000269|PubMed:15723541, ECO:0007744|PDB:1SF2, ECO:0007744|PDB:1SZS, ECO:0007744|PDB:1SZU
ChainResidueDetails
ALYS268
BLYS268
CLYS268
DLYS268

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
ATYR138
ALYS268
AASP239

site_idCSA10
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
BTYR155
BLYS268
BASP239

site_idCSA11
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
CTYR155
CLYS268
CASP239

site_idCSA12
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
DTYR155
DLYS268
DASP239

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
BTYR138
BLYS268
BASP239

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
CTYR138
CLYS268
CASP239

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
DTYR138
DLYS268
DASP239

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
ALYS268
AHIS139
AASP239

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
BLYS268
BHIS139
BASP239

site_idCSA7
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
CLYS268
CHIS139
CASP239

site_idCSA8
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
DLYS268
DHIS139
DASP239

site_idCSA9
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ay4
ChainResidueDetails
ATYR155
ALYS268
AASP239

223166

PDB entries from 2024-07-31

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