1SY3

1.00 A Crystal Structure of D30N Mutant of Nitrophorin 4 from Rhodnius Prolixus Complexed with Nitric Oxide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0016491	molecular_function	oxidoreductase activity
A	0042311	biological_process	vasodilation
A	0046872	molecular_function	metal ion binding
A	0051381	molecular_function	histamine binding
A	0070026	molecular_function	nitric oxide binding
A	0097746	biological_process	blood vessel diameter maintenance

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 587

Chain	Residue
A	THR10
A	GLY11
A	PRO37
A	LYS38
A	ARG39
A	LYS63
A	HOH669
A	HOH695

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM A 185

Chain	Residue
A	VAL36
A	TYR40
A	LEU44
A	LEU57
A	HIS59
A	PHE68
A	ASP70
A	PHE86
A	LYS88
A	TYR105
A	LEU123
A	LYS125
A	LEU130
A	LEU133
A	NO186
A	HOH836
A	VAL25

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NO A 186

Chain	Residue
A	LEU123
A	LEU133
A	HEM185
A	HOH894

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"description":"proximal binding residue","evidences":[{"source":"PubMed","id":"10876239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11560480","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14673714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16171383","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20524697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22334402","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22976968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23474537","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9782054","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---