1SU3

X-ray structure of human proMMP-1: New insights into collagenase action

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004222	molecular_function	metalloendopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0022617	biological_process	extracellular matrix disassembly
A	0030198	biological_process	extracellular matrix organization
A	0030574	biological_process	collagen catabolic process
A	0031012	cellular_component	extracellular matrix
A	0031334	biological_process	positive regulation of protein-containing complex assembly
A	0046872	molecular_function	metal ion binding
A	0071492	biological_process	cellular response to UV-A
B	0004175	molecular_function	endopeptidase activity
B	0004222	molecular_function	metalloendopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0022617	biological_process	extracellular matrix disassembly
B	0030198	biological_process	extracellular matrix organization
B	0030574	biological_process	collagen catabolic process
B	0031012	cellular_component	extracellular matrix
B	0031334	biological_process	positive regulation of protein-containing complex assembly
B	0046872	molecular_function	metal ion binding
B	0071492	biological_process	cellular response to UV-A

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 901

Chain	Residue
A	ALA157
A	ASP158
A	GLY190
A	GLY192
A	ASP194
A	HOH1027

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 902

Chain	Residue
A	HOH946
A	HOH991
A	ASP124
A	GLU199
A	GLU201

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 903

Chain	Residue
A	ASP175
A	GLY176
A	GLY178
A	ASN180
A	ASP198
A	GLU201

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 904

Chain	Residue
A	ASP285
A	GLU329
A	ASP378
A	ASP427
A	HOH916
A	HOH961
A	HOH1052

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 905

Chain	Residue
B	ALA157
B	ASP158
B	GLY190
B	GLY192
B	ASP194

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 906

Chain	Residue
B	ASP175
B	GLY176
B	GLY178
B	ASN180
B	ASP198
B	GLU201

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 907

Chain	Residue
B	ASP124
B	GLU199
B	GLU201
B	HOH1085

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 908

Chain	Residue
B	ASP285
B	GLU329
B	ASP378
B	ASP427
B	HOH1052
B	HOH1053
B	HOH1080

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 909

Chain	Residue
A	ILE287
A	ALA331
A	ALA380
A	VAL429
A	NA911

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL B 910

Chain	Residue
B	ILE287
B	ALA331
B	ALA380
B	ALA428
B	VAL429
B	NA912

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 911

Chain	Residue
A	ILE287
A	ALA331
A	ALA380
A	VAL429
A	CL909
A	HOH1088

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 912

Chain	Residue
B	ILE287
B	ALA331
B	ALA380
B	VAL429
B	CL910
B	HOH980

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 913

Chain	Residue
A	CYS92
A	HIS218
A	HIS222
A	HIS228

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 915

Chain	Residue
A	HIS168
A	ASP170
A	HIS183
A	HIS196

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 913

Chain	Residue
B	CYS92
B	HIS218
B	HIS222
B	HIS228

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 915

Chain	Residue
B	HIS168
B	ASP170
B	HIS183
B	HIS196

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 500

Chain	Residue
B	PRO189
B	GLY190
B	LYS404

---

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 501

Chain	Residue
B	ASP167
B	HIS168
B	ARG169
B	ASP170
B	ASN171
B	PRO173
B	HOH946

---

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 504

Chain	Residue
B	PRO126
B	ARG127

---

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 503

Chain	Residue
B	SER263
B	GLN264
B	ASN265
B	HOH918
B	SER142
B	THR145

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 801

Chain	Residue
A	PRO126
A	ARG127
A	LYS404
A	HOH1050
A	HOH1104

---

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EPE B 600

Chain	Residue
B	VAL94
B	PRO95
B	SER172
B	ALA184
B	PHE185
B	GLN186
B	HOH959

---

Functional Information from PROSITE/UniProt

site_id	PS00024
Number of Residues	16
Details	HEMOPEXIN Hemopexin domain signature. ISvfWpqlPnGLEAAY

Chain	Residue	Details
A	ILE317-TYR332

---

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL

Chain	Residue	Details
A	VAL215-LEU224

---

site_id	PS00546
Number of Residues	8
Details	CYSTEINE_SWITCH Matrixins cysteine switch. PRCGvPDV

Chain	Residue	Details
A	PRO90-VAL97

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	98
Details	Repeat: {"description":"Hemopexin 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	92
Details	Repeat: {"description":"Hemopexin 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	96
Details	Repeat: {"description":"Hemopexin 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	43
Details	Repeat: {"description":"Hemopexin 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Motif: {"description":"Cysteine switch","evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2153297","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"description":"in inhibited form","evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"10092871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"2557822","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"25171405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by PKDCC","evidences":[{"source":"PubMed","id":"25171405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000105","evidences":[{"source":"PubMed","id":"10092871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"25171405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
A	MET236
A	GLU219

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
B	MET236
B	GLU219

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
A	GLU219

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
B	GLU219

---