1STO

CRYSTAL STRUCTURE OF OROTATE PHOSPHORIBOSYLTRANSFERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004588	molecular_function	orotate phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0072528	biological_process	pyrimidine-containing compound biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE OH A 214

Chain	Residue
A	VAL213

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE OMP A 216

Chain	Residue
A	ALA129
A	THR131
A	ARG156
A	LEU25
A	LYS26
A	PHE34
A	PHE35
A	LYS73
A	VAL126
A	ILE127
A	THR128

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Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VMLVDDVITAGtA

Chain	Residue	Details
A	VAL120-ALA132

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: in other chain => ECO:0000269|PubMed:7545004

Chain	Residue	Details
A	SER27
A	LYS73
A	ALA101
A	ASP125

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:7545004

Chain	Residue	Details
A	PHE35
A	LYS100
A	ASP104
A	GLY106
A	ALA129
A	GLN157

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