1ST0
Structure of DcpS bound to m7GpppG
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000288 | biological_process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| A | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| A | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| A | 0000932 | cellular_component | P-body |
| A | 0004532 | molecular_function | RNA exonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008380 | biological_process | RNA splicing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0106095 | cellular_component | m7G(5')pppN diphosphatase complex |
| A | 0110156 | biological_process | mRNA methylguanosine-cap decapping |
| A | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
| B | 0000288 | biological_process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| B | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| B | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| B | 0000932 | cellular_component | P-body |
| B | 0004532 | molecular_function | RNA exonuclease activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008380 | biological_process | RNA splicing |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0106095 | cellular_component | m7G(5')pppN diphosphatase complex |
| B | 0110156 | biological_process | mRNA methylguanosine-cap decapping |
| B | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE YT3 A 701 |
| Chain | Residue |
| A | ASP74 |
| A | GLU92 |
| A | YT3702 |
| A | HOH955 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE YT3 A 702 |
| Chain | Residue |
| A | ASP74 |
| A | ASP76 |
| A | GLU92 |
| A | YT3701 |
| A | HOH943 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE YT3 A 703 |
| Chain | Residue |
| A | ASP76 |
| A | HOH919 |
| A | HOH932 |
| A | HOH935 |
| site_id | AC4 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE GTG A 651 |
| Chain | Residue |
| A | ARG54 |
| A | ASP59 |
| A | ILE61 |
| A | GLU85 |
| A | LYS128 |
| A | LYS142 |
| A | TRP175 |
| A | GLU185 |
| A | PRO204 |
| A | ASP205 |
| A | LEU206 |
| A | LYS207 |
| A | HIS268 |
| A | PRO271 |
| A | SER272 |
| A | TYR273 |
| A | ASN277 |
| A | HIS279 |
| A | PRO288 |
| A | ARG294 |
| A | HOH704 |
| A | HOH708 |
| A | HOH737 |
| A | HOH738 |
| A | HOH741 |
| A | HOH751 |
| A | HOH771 |
| A | HOH809 |
| A | HOH814 |
| A | HOH838 |
| A | HOH868 |
| B | PHE108 |
| B | ASN110 |
| B | TYR113 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GTG B 652 |
| Chain | Residue |
| B | ARG145 |
| B | TRP175 |
| B | GLU185 |
| B | ARG188 |
| B | ILE203 |
| B | PRO204 |
| B | ASP205 |
| B | LEU206 |
| B | LYS207 |
| B | ILE219 |
| B | HIS268 |
| B | PRO271 |
| B | SER272 |
| B | TYR273 |
| B | ASN277 |
| B | HIS279 |
| B | ARG294 |
| B | ARG322 |
| B | HOH695 |
| B | HOH918 |
| B | HOH919 |
| B | HOH940 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Motif: {"description":"nuclear export sequence (NES)"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Histidine triad motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15068804","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15769464","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9DAR7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
