Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE SO4 A 246 |
Chain | Residue |
A | ARG48 |
A | HOH454 |
A | HOH520 |
A | HOH566 |
A | HOH568 |
A | HOH708 |
A | ARG120 |
A | GLN237 |
A | TYR238 |
A | HOH313 |
A | HOH314 |
A | HOH422 |
A | HOH423 |
A | HOH424 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE SO4 A 247 |
Chain | Residue |
A | ALA15 |
A | ASN15 |
A | ARG230 |
A | PRO233 |
A | HOH349 |
A | HOH398 |
A | HOH437 |
A | HOH438 |
A | HOH506 |
A | HOH513 |
A | HOH513 |
A | HOH679 |
A | HOH702 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE SO4 A 248 |
Chain | Residue |
A | HIS57 |
A | ARG122 |
A | ARG192 |
A | GLY193 |
A | SER195 |
A | GOL249 |
A | HOH467 |
A | HOH469 |
A | HOH529 |
A | HOH700 |
A | HOH760 |
A | HOH764 |
A | HOH765 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE SO4 A 203 |
Chain | Residue |
A | ALA48 |
A | THR49 |
A | SER110 |
A | ALA176 |
A | ARG178 |
A | HOH311 |
A | HOH367 |
A | HOH368 |
A | HOH569 |
A | HOH654 |
A | HOH745 |
A | HOH754 |
site_id | AC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE GOL A 249 |
Chain | Residue |
A | HIS57 |
A | ARG122 |
A | TYR171 |
A | GLU174 |
A | ARG192 |
A | SER214 |
A | GLY215 |
A | SO4248 |
A | HOH355 |
A | HOH468 |
A | HOH570 |
site_id | AC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GOL A 250 |
Chain | Residue |
A | PHE120 |
A | VAL120 |
A | THR120 |
A | ALA173 |
A | GLU174 |
A | HOH453 |
A | HOH517 |
A | HOH640 |
A | HOH705 |
A | HOH709 |
Functional Information from PROSITE/UniProt
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAGHC |
Chain | Residue | Details |
A | VAL53-CYS58 | |
site_id | PS00135 |
Number of Residues | 12 |
Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. CMgrGDSGGSWI |
Chain | Residue | Details |
A | CYS189-ILE200 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | ACT_SITE: Charge relay system => ECO:0000250 |
Chain | Residue | Details |
A | HIS57 | |
A | ASP102 | |
A | SER195 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 6 |
Details | a catalytic site defined by CSA, PubMed 15111063, 9808037 |
Chain | Residue | Details |
A | ASP102 | |
A | SER195 | |
A | SER195 | |
A | GLY193 | |
A | HIS57 | |
A | SER214 | |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 609 |
Chain | Residue | Details |
A | HIS57 | proton acceptor, proton donor |
A | ASP102 | electrostatic stabiliser |
A | GLY193 | electrostatic stabiliser |
A | SER195 | electrostatic stabiliser |
A | SER214 | electrostatic stabiliser |