Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SO4 A 246 |
| Chain | Residue |
| A | ARG48 |
| A | HOH454 |
| A | HOH520 |
| A | HOH566 |
| A | HOH568 |
| A | HOH708 |
| A | ARG120 |
| A | GLN237 |
| A | TYR238 |
| A | HOH313 |
| A | HOH314 |
| A | HOH422 |
| A | HOH423 |
| A | HOH424 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SO4 A 247 |
| Chain | Residue |
| A | ALA15 |
| A | ASN15 |
| A | ARG230 |
| A | PRO233 |
| A | HOH349 |
| A | HOH398 |
| A | HOH437 |
| A | HOH438 |
| A | HOH506 |
| A | HOH513 |
| A | HOH513 |
| A | HOH679 |
| A | HOH702 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SO4 A 248 |
| Chain | Residue |
| A | HIS57 |
| A | ARG122 |
| A | ARG192 |
| A | GLY193 |
| A | SER195 |
| A | GOL249 |
| A | HOH467 |
| A | HOH469 |
| A | HOH529 |
| A | HOH700 |
| A | HOH760 |
| A | HOH764 |
| A | HOH765 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 A 203 |
| Chain | Residue |
| A | ALA48 |
| A | THR49 |
| A | SER110 |
| A | ALA176 |
| A | ARG178 |
| A | HOH311 |
| A | HOH367 |
| A | HOH368 |
| A | HOH569 |
| A | HOH654 |
| A | HOH745 |
| A | HOH754 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 249 |
| Chain | Residue |
| A | HIS57 |
| A | ARG122 |
| A | TYR171 |
| A | GLU174 |
| A | ARG192 |
| A | SER214 |
| A | GLY215 |
| A | SO4248 |
| A | HOH355 |
| A | HOH468 |
| A | HOH570 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 250 |
| Chain | Residue |
| A | PHE120 |
| A | VAL120 |
| A | THR120 |
| A | ALA173 |
| A | GLU174 |
| A | HOH453 |
| A | HOH517 |
| A | HOH640 |
| A | HOH705 |
| A | HOH709 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAGHC |
| Chain | Residue | Details |
| A | VAL53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. CMgrGDSGGSWI |
| Chain | Residue | Details |
| A | CYS189-ILE200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS57 | |
| A | ASP102 | |
| A | SER195 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 15111063, 9808037 |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
| A | SER214 | |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 609 |
| Chain | Residue | Details |
| A | HIS57 | proton acceptor, proton donor |
| A | ASP102 | electrostatic stabiliser |
| A | GLY193 | electrostatic stabiliser |
| A | SER195 | electrostatic stabiliser |
| A | SER214 | electrostatic stabiliser |
