Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1SQL

Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004150	molecular_function	dihydroneopterin aldolase activity
A	0005737	cellular_component	cytoplasm
A	0006760	biological_process	folic acid-containing compound metabolic process
A	0016829	molecular_function	lyase activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046656	biological_process	folic acid biosynthetic process
B	0004150	molecular_function	dihydroneopterin aldolase activity
B	0005737	cellular_component	cytoplasm
B	0006760	biological_process	folic acid-containing compound metabolic process
B	0016829	molecular_function	lyase activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046656	biological_process	folic acid biosynthetic process
C	0004150	molecular_function	dihydroneopterin aldolase activity
C	0005737	cellular_component	cytoplasm
C	0006760	biological_process	folic acid-containing compound metabolic process
C	0016829	molecular_function	lyase activity
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046656	biological_process	folic acid biosynthetic process
D	0004150	molecular_function	dihydroneopterin aldolase activity
D	0005737	cellular_component	cytoplasm
D	0006760	biological_process	folic acid-containing compound metabolic process
D	0016829	molecular_function	lyase activity
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0046656	biological_process	folic acid biosynthetic process
E	0004150	molecular_function	dihydroneopterin aldolase activity
E	0005737	cellular_component	cytoplasm
E	0006760	biological_process	folic acid-containing compound metabolic process
E	0016829	molecular_function	lyase activity
E	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0046656	biological_process	folic acid biosynthetic process
F	0004150	molecular_function	dihydroneopterin aldolase activity
F	0005737	cellular_component	cytoplasm
F	0006760	biological_process	folic acid-containing compound metabolic process
F	0016829	molecular_function	lyase activity
F	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0046656	biological_process	folic acid biosynthetic process
G	0004150	molecular_function	dihydroneopterin aldolase activity
G	0005737	cellular_component	cytoplasm
G	0006760	biological_process	folic acid-containing compound metabolic process
G	0016829	molecular_function	lyase activity
G	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0046656	biological_process	folic acid biosynthetic process
H	0004150	molecular_function	dihydroneopterin aldolase activity
H	0005737	cellular_component	cytoplasm
H	0006760	biological_process	folic acid-containing compound metabolic process
H	0016829	molecular_function	lyase activity
H	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0046656	biological_process	folic acid biosynthetic process
I	0004150	molecular_function	dihydroneopterin aldolase activity
I	0005737	cellular_component	cytoplasm
I	0006760	biological_process	folic acid-containing compound metabolic process
I	0016829	molecular_function	lyase activity
I	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0046656	biological_process	folic acid biosynthetic process
J	0004150	molecular_function	dihydroneopterin aldolase activity
J	0005737	cellular_component	cytoplasm
J	0006760	biological_process	folic acid-containing compound metabolic process
J	0016829	molecular_function	lyase activity
J	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0046656	biological_process	folic acid biosynthetic process
K	0004150	molecular_function	dihydroneopterin aldolase activity
K	0005737	cellular_component	cytoplasm
K	0006760	biological_process	folic acid-containing compound metabolic process
K	0016829	molecular_function	lyase activity
K	0046654	biological_process	tetrahydrofolate biosynthetic process
K	0046656	biological_process	folic acid biosynthetic process
L	0004150	molecular_function	dihydroneopterin aldolase activity
L	0005737	cellular_component	cytoplasm
L	0006760	biological_process	folic acid-containing compound metabolic process
L	0016829	molecular_function	lyase activity
L	0046654	biological_process	tetrahydrofolate biosynthetic process
L	0046656	biological_process	folic acid biosynthetic process
M	0004150	molecular_function	dihydroneopterin aldolase activity
M	0005737	cellular_component	cytoplasm
M	0006760	biological_process	folic acid-containing compound metabolic process
M	0016829	molecular_function	lyase activity
M	0046654	biological_process	tetrahydrofolate biosynthetic process
M	0046656	biological_process	folic acid biosynthetic process
N	0004150	molecular_function	dihydroneopterin aldolase activity
N	0005737	cellular_component	cytoplasm
N	0006760	biological_process	folic acid-containing compound metabolic process
N	0016829	molecular_function	lyase activity
N	0046654	biological_process	tetrahydrofolate biosynthetic process
N	0046656	biological_process	folic acid biosynthetic process
O	0004150	molecular_function	dihydroneopterin aldolase activity
O	0005737	cellular_component	cytoplasm
O	0006760	biological_process	folic acid-containing compound metabolic process
O	0016829	molecular_function	lyase activity
O	0046654	biological_process	tetrahydrofolate biosynthetic process
O	0046656	biological_process	folic acid biosynthetic process
P	0004150	molecular_function	dihydroneopterin aldolase activity
P	0005737	cellular_component	cytoplasm
P	0006760	biological_process	folic acid-containing compound metabolic process
P	0016829	molecular_function	lyase activity
P	0046654	biological_process	tetrahydrofolate biosynthetic process
P	0046656	biological_process	folic acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GUN A 1001

Chain	Residue
A	ILE51
A	SER52
A	TYR53
A	HOH1010
D	LEU71
D	LEU72
D	GLU73

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GUN B 1002

Chain	Residue
A	GLU73
B	LEU4
B	THR50
B	ILE51
B	SER52
B	TYR53
B	HOH1010
A	LEU71
A	LEU72

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GUN B 1003

Chain	Residue
B	LEU71
B	LEU72
B	GLU73
B	HOH1066
C	ILE51
C	SER52
C	TYR53

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GUN D 1004

Chain	Residue
C	LEU71
C	LEU72
C	GLU73
C	HOH128
D	ILE51
D	SER52
D	TYR53

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GUN H 1005

Chain	Residue
E	LEU4
E	THR50
E	ILE51
E	SER52
E	TYR53
H	LEU71
H	LEU72
H	GLU73
H	HOH1029
H	HOH1070

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GUN F 1006

Chain	Residue
E	LEU71
E	LEU72
E	GLU73
F	LEU47
F	THR50
F	ILE51
F	SER52
F	TYR53
F	HOH1022

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GUN G 1007

Chain	Residue
F	LEU71
F	LEU72
F	GLU73
G	LEU4
G	THR50
G	ILE51
G	SER52
G	TYR53
G	HOH1035

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GUN G 1008

Chain	Residue
G	LEU71
G	LEU72
G	GLU73
G	HOH1021
G	HOH1073
H	LEU4
H	LEU47
H	THR50
H	ILE51
H	SER52
H	TYR53

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GUN I 1009

Chain	Residue
I	LEU4
I	LEU47
I	THR50
I	ILE51
I	SER52
I	TYR53
L	LEU71
L	LEU72
L	GLU73
L	HOH1019

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GUN J 1010

Chain	Residue
I	LEU71
I	LEU72
I	GLU73
I	HOH1066
J	ILE51
J	SER52
J	TYR53
J	HOH1057

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GUN J 1011

Chain	Residue
J	LEU71
J	LEU72
J	GLU73
J	HOH1013
J	HOH1079
K	ILE51
K	SER52
K	TYR53
K	HOH131

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GUN L 1012

Chain	Residue
K	HOH132
K	HOH180
L	LEU4
L	THR50
L	ILE51
L	SER52
L	TYR53
K	LEU71
K	LEU72
K	GLU73

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GUN P 1013

Chain	Residue
M	LEU4
M	THR50
M	ILE51
M	SER52
M	TYR53
P	LEU71
P	LEU72
P	GLU73
P	HOH1030

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GUN M 1014

Chain	Residue
M	LEU71
M	LEU72
M	GLU73
M	HOH1019
N	ILE51
N	SER52
N	TYR53

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GUN O 1015

Chain	Residue
N	LEU71
N	LEU72
N	GLU73
O	LEU4
O	THR50
O	ILE51
O	SER52
O	TYR53
O	HOH1023

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GUN P 1016

Chain	Residue
O	LEU71
O	LEU72
O	GLU73
P	THR50
P	ILE51
P	SER52
P	TYR53
P	HOH1026

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"15165863","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P0AC16","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"15165863","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
A	GLU21
A	LYS99

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
J	GLU21
J	LYS99

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
K	GLU21
K	LYS99

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
L	GLU21
L	LYS99

site_id	CSA13
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
M	GLU21
M	LYS99

site_id	CSA14
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
N	GLU21
N	LYS99

site_id	CSA15
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
O	GLU21
O	LYS99

site_id	CSA16
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
P	GLU21
P	LYS99

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
B	GLU21
B	LYS99

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
C	GLU21
C	LYS99

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
D	GLU21
D	LYS99

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
E	GLU21
E	LYS99

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
F	GLU21
F	LYS99

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
G	GLU21
G	LYS99

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
H	GLU21
H	LYS99

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
I	GLU21
I	LYS99

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)