1SP4
Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE EP2 B 48 |
| Chain | Residue |
| A | GLN23 |
| B | HIS110 |
| B | HIS111 |
| B | ALA173 |
| B | ALA173 |
| B | PHE174 |
| B | SER175 |
| B | GLY198 |
| B | HIS199 |
| B | TRP221 |
| B | GLY241 |
| A | GLY24 |
| B | SER244 |
| B | GLU245 |
| B | HOH291 |
| B | HOH327 |
| B | HOH354 |
| A | GLY27 |
| A | SER28 |
| A | CYS29 |
| A | TRP30 |
| B | GLY73 |
| B | GLY74 |
| B | PRO76 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGsCGSCWAfGA |
| Chain | Residue | Details |
| A | GLN23-ALA34 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GGHAIRILGWG |
| Chain | Residue | Details |
| B | GLY197-GLY207 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvGNSWntdWGdnGFFkI |
| Chain | Residue | Details |
| B | TYR214-ILE233 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10739956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7106283","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10739956","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10739956","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P10605","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3379063","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
