1SO0

Crystal structure of human galactose mutarotase complexed with galactose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004034	molecular_function	aldose 1-epimerase activity
A	0005737	cellular_component	cytoplasm
A	0005975	biological_process	carbohydrate metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006012	biological_process	galactose metabolic process
A	0016853	molecular_function	isomerase activity
A	0019318	biological_process	hexose metabolic process
A	0030246	molecular_function	carbohydrate binding
A	0033499	biological_process	galactose catabolic process via UDP-galactose
A	0042803	molecular_function	protein homodimerization activity
A	0070062	cellular_component	extracellular exosome
B	0003824	molecular_function	catalytic activity
B	0004034	molecular_function	aldose 1-epimerase activity
B	0005737	cellular_component	cytoplasm
B	0005975	biological_process	carbohydrate metabolic process
B	0006006	biological_process	glucose metabolic process
B	0006012	biological_process	galactose metabolic process
B	0016853	molecular_function	isomerase activity
B	0019318	biological_process	hexose metabolic process
B	0030246	molecular_function	carbohydrate binding
B	0033499	biological_process	galactose catabolic process via UDP-galactose
B	0042803	molecular_function	protein homodimerization activity
B	0070062	cellular_component	extracellular exosome
C	0003824	molecular_function	catalytic activity
C	0004034	molecular_function	aldose 1-epimerase activity
C	0005737	cellular_component	cytoplasm
C	0005975	biological_process	carbohydrate metabolic process
C	0006006	biological_process	glucose metabolic process
C	0006012	biological_process	galactose metabolic process
C	0016853	molecular_function	isomerase activity
C	0019318	biological_process	hexose metabolic process
C	0030246	molecular_function	carbohydrate binding
C	0033499	biological_process	galactose catabolic process via UDP-galactose
C	0042803	molecular_function	protein homodimerization activity
C	0070062	cellular_component	extracellular exosome
D	0003824	molecular_function	catalytic activity
D	0004034	molecular_function	aldose 1-epimerase activity
D	0005737	cellular_component	cytoplasm
D	0005975	biological_process	carbohydrate metabolic process
D	0006006	biological_process	glucose metabolic process
D	0006012	biological_process	galactose metabolic process
D	0016853	molecular_function	isomerase activity
D	0019318	biological_process	hexose metabolic process
D	0030246	molecular_function	carbohydrate binding
D	0033499	biological_process	galactose catabolic process via UDP-galactose
D	0042803	molecular_function	protein homodimerization activity
D	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00545
Number of Residues	10
Details	ALDOSE_1_EPIMERASE Aldose 1-epimerase putative active site. NlTNHsYFNL

Chain	Residue	Details
A	ASN172-LEU181

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:15026423

Chain	Residue	Details
A	HIS176
B	HIS176
C	HIS176
D	HIS176

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:15026423

Chain	Residue	Details
A	GLU307
B	GLU307
C	GLU307
D	GLU307

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site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:15026423, ECO:0007744|PDB:1SO0

Chain	Residue	Details
A	ASN81
B	ASP243
B	GLN279
B	GLU307
C	ASN81
C	HIS107
C	HIS176
C	ASP243
C	GLN279
C	GLU307
D	ASN81
A	HIS107
D	HIS107
D	HIS176
D	ASP243
D	GLN279
D	GLU307
A	HIS176
A	ASP243
A	GLN279
A	GLU307
B	ASN81
B	HIS107
B	HIS176

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2

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site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER14
B	SER14
C	SER14
D	SER14

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site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q66HG4

Chain	Residue	Details
A	SER124
B	SER124
C	SER124
D	SER124

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 351

Chain	Residue	Details
A	HIS107	electrostatic stabiliser, hydrogen bond acceptor
A	HIS176	activator, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	GLU307	activator, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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site_id	MCSA2
Number of Residues	3
Details	M-CSA 351

Chain	Residue	Details
B	HIS107	electrostatic stabiliser, hydrogen bond acceptor
B	HIS176	activator, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	GLU307	activator, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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site_id	MCSA3
Number of Residues	3
Details	M-CSA 351

Chain	Residue	Details
C	HIS107	electrostatic stabiliser, hydrogen bond acceptor
C	HIS176	activator, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
C	GLU307	activator, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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site_id	MCSA4
Number of Residues	3
Details	M-CSA 351

Chain	Residue	Details
D	HIS107	electrostatic stabiliser, hydrogen bond acceptor
D	HIS176	activator, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
D	GLU307	activator, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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