1SMC
Mycobacterium tuberculosis dUTPase complexed with dUTP in the absence of metal ion.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004170 | molecular_function | dUTP diphosphatase activity |
| A | 0006220 | biological_process | pyrimidine nucleotide metabolic process |
| A | 0006226 | biological_process | dUMP biosynthetic process |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046080 | biological_process | dUTP metabolic process |
| A | 0046081 | biological_process | dUTP catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004170 | molecular_function | dUTP diphosphatase activity |
| B | 0006220 | biological_process | pyrimidine nucleotide metabolic process |
| B | 0006226 | biological_process | dUMP biosynthetic process |
| B | 0009117 | biological_process | nucleotide metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046080 | biological_process | dUTP metabolic process |
| B | 0046081 | biological_process | dUTP catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004170 | molecular_function | dUTP diphosphatase activity |
| C | 0006220 | biological_process | pyrimidine nucleotide metabolic process |
| C | 0006226 | biological_process | dUMP biosynthetic process |
| C | 0009117 | biological_process | nucleotide metabolic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0046080 | biological_process | dUTP metabolic process |
| C | 0046081 | biological_process | dUTP catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 C 155 |
| Chain | Residue |
| A | PHE130 |
| A | ASP131 |
| B | THR4 |
| B | ALA6 |
| C | ARG87 |
| C | VAL127 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE DUT C 1170 |
| Chain | Residue |
| A | ILE82 |
| A | ASP83 |
| A | TYR86 |
| A | GLU89 |
| A | ILE90 |
| A | LYS91 |
| B | ARG140 |
| C | ARG64 |
| C | SER65 |
| C | GLY66 |
| C | GLN113 |
| C | HOH197 |
| C | HOH204 |
| C | HOH232 |
| C | HOH282 |
| C | HOH292 |
| C | HOH369 |
| A | ASN77 |
| A | GLY80 |
| A | THR81 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE DUT A 2170 |
| Chain | Residue |
| A | ARG64 |
| A | SER65 |
| A | GLY66 |
| A | GLN113 |
| A | HOH182 |
| A | HOH222 |
| A | HOH269 |
| A | HOH314 |
| A | HOH364 |
| A | HOH365 |
| B | ASN77 |
| B | GLY80 |
| B | THR81 |
| B | ILE82 |
| B | ASP83 |
| B | TYR86 |
| B | GLU89 |
| B | ILE90 |
| B | LYS91 |
| B | HOH251 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE DUT C 3170 |
| Chain | Residue |
| B | ASP28 |
| B | PRO63 |
| B | ARG64 |
| B | SER65 |
| B | GLY66 |
| B | GLN113 |
| B | HOH306 |
| C | ASN77 |
| C | GLY80 |
| C | THR81 |
| C | ILE82 |
| C | ASP83 |
| C | TYR86 |
| C | GLU89 |
| C | ILE90 |
| C | LYS91 |
| C | HOH169 |
| C | HOH241 |
| C | HOH275 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE TRS C 3171 |
| Chain | Residue |
| A | SER74 |
| A | ILE75 |
| A | VAL76 |
| B | SER74 |
| B | ILE75 |
| C | SER74 |
| C | ILE75 |
| C | VAL76 |
| C | LEU97 |
| C | HOH181 |
| C | HOH191 |
| C | HOH198 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TRS A 2171 |
| Chain | Residue |
| A | LEU60 |
| A | HIS62 |
| A | PRO79 |
| A | GLN117 |
| B | LEU60 |
| B | HIS62 |
| B | GLN117 |
| C | LEU60 |
| C | HIS62 |
| C | PRO79 |
| C | GLN117 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TRS B 155 |
| Chain | Residue |
| A | GLY40 |
| B | LEU97 |
| B | HOH236 |
| B | HOH301 |
| B | HOH344 |
| C | GLY40 |
| C | ASN96 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00116, ECO:0000269|PubMed:15276840 |
| Chain | Residue | Details |
| A | ARG64 | |
| A | ASN77 | |
| A | THR81 | |
| B | ARG64 | |
| B | ASN77 | |
| B | THR81 | |
| C | ARG64 | |
| C | ASN77 | |
| C | THR81 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15276840 |
| Chain | Residue | Details |
| A | LYS91 | |
| B | LYS91 | |
| C | LYS91 |
