Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 257 |
| Chain | Residue |
| A | HIS201 |
| A | HIS205 |
| A | HIS211 |
| A | 8MI256 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 258 |
| Chain | Residue |
| A | HIS151 |
| A | ASP153 |
| A | HIS166 |
| A | HIS179 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 259 |
| Chain | Residue |
| A | ASP158 |
| A | GLY159 |
| A | GLY161 |
| A | VAL163 |
| A | ASP181 |
| A | GLU184 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 260 |
| Chain | Residue |
| A | ASP141 |
| A | GLY173 |
| A | ASN175 |
| A | ASP177 |
| A | HOH306 |
| A | HOH312 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 261 |
| Chain | Residue |
| A | ASP107 |
| A | ASP182 |
| A | GLU184 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 8MI A 256 |
| Chain | Residue |
| A | GLY152 |
| A | ASP153 |
| A | PHE154 |
| A | ASN162 |
| A | LEU164 |
| A | ALA165 |
| A | LEU197 |
| A | VAL198 |
| A | HIS201 |
| A | GLU202 |
| A | HIS205 |
| A | HIS211 |
| A | LEU218 |
| A | TYR220 |
| A | PRO221 |
| A | LEU222 |
| A | TYR223 |
| A | ZN257 |
| A | HOH301 |
| A | HOH502 |
| A | HOH504 |
| A | HOH519 |
| site_id | CA1 |
| Number of Residues | 6 |
| Details | CA1 ARE THE LIGANDS OF THE CALCIUM ION CA 259 |
| Chain | Residue |
| A | ASP158 |
| A | GLY159 |
| A | GLY161 |
| A | VAL163 |
| A | ASP181 |
| A | GLU184 |
| site_id | CA2 |
| Number of Residues | 6 |
| Details | CA2 ARE THE LIGANDS OF THE CALCIUM ION CA 260 |
| Chain | Residue |
| A | ASP141 |
| A | GLY173 |
| A | ASN175 |
| A | ASP177 |
| A | HOH306 |
| A | HOH312 |
| site_id | CA3 |
| Number of Residues | 3 |
| Details | CA3 ARE THE LIGANDS OF THE CALCIUM ION CA 261 |
| Chain | Residue |
| A | ASP107 |
| A | ASP182 |
| A | GLU184 |
| site_id | INH |
| Number of Residues | 18 |
| Details | SITE INH IS THE BINDING SITE FOR THE N-CARBOXY-ALKYL INHIBITOR L-702,842, DENOTED INH 256. |
| Chain | Residue |
| A | ASN162 |
| A | HIS211 |
| A | LEU218 |
| A | TYR220 |
| A | PRO221 |
| A | LEU222 |
| A | TYR223 |
| A | ZN257 |
| A | HOH301 |
| A | HOH502 |
| A | VAL163 |
| A | LEU164 |
| A | ALA165 |
| A | LEU197 |
| A | VAL198 |
| A | HIS201 |
| A | GLU202 |
| A | HIS205 |
| site_id | ZN1 |
| Number of Residues | 4 |
| Details | ZN1 ARE THE LIGANDS OF THE CATALYTIC (ZN 257) ZINC ION. |
| Chain | Residue |
| A | HIS201 |
| A | HIS205 |
| A | HIS211 |
| A | 8MI256 |
| site_id | ZN2 |
| Number of Residues | 4 |
| Details | ZN2 ARE THE LIGANDS OF THE STRUCTURAL (ZN 258) ZINC ION. |
| Chain | Residue |
| A | HIS151 |
| A | ASP153 |
| A | HIS166 |
| A | HIS179 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEIGHSL |
| Chain | Residue | Details |
| A | VAL198-LEU207 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | GLU202 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP107 | |
| A | GLY173 | |
| A | ASN175 | |
| A | ASP177 | |
| A | HIS179 | |
| A | ASP181 | |
| A | ASP182 | |
| A | GLU184 | |
| A | ASP141 | |
| A | HIS151 | |
| A | ASP153 | |
| A | ASP158 | |
| A | GLY159 | |
| A | GLY161 | |
| A | VAL163 | |
| A | HIS166 | |
| Chain | Residue | Details |
| A | HIS201 | |
| A | HIS205 | |
| A | HIS211 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | MET219 | |
| A | GLU202 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU202 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 591 |
| Chain | Residue | Details |
| A | HIS201 | metal ligand |
| A | GLU202 | proton acceptor, proton donor |
| A | HIS205 | metal ligand |
| A | HIS211 | metal ligand |
