1SJD

x-ray structure of o-succinylbenzoate synthase complexed with n-succinyl phenylglycine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0009234	biological_process	menaquinone biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0043748	molecular_function	O-succinylbenzoate synthase activity
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0009234	biological_process	menaquinone biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016853	molecular_function	isomerase activity
B	0043748	molecular_function	O-succinylbenzoate synthase activity
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0009234	biological_process	menaquinone biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016853	molecular_function	isomerase activity
C	0043748	molecular_function	O-succinylbenzoate synthase activity
C	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0009234	biological_process	menaquinone biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016853	molecular_function	isomerase activity
D	0043748	molecular_function	O-succinylbenzoate synthase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NPG A 1200

Chain	Residue
A	MET50
A	ASP316
A	PHE323
A	HOH1201
A	HOH1222
A	HOH1303
A	HOH1382
A	SER135
A	LYS161
A	LYS163
A	ASN191
A	LYS263
A	GLY291
A	MET292
A	ILE293

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NPG B 1300

Chain	Residue
B	PHE23
B	MET50
B	SER135
B	LYS163
B	ASN191
B	LYS263
B	GLY291
B	MET292
B	ILE293
B	ASP316
B	PHE323
B	HOH1301
B	HOH1330
B	HOH1560
B	HOH1561

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NPG C 1400

Chain	Residue
C	MET50
C	SER135
C	LYS161
C	LYS163
C	ASN191
C	LYS263
C	GLY291
C	MET292
C	ILE293
C	ASP316
C	PHE323
C	HOH1401
C	HOH1418
C	HOH1468
C	HOH1582

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE NPG D 1500

Chain	Residue
D	MET50
D	SER135
D	LYS161
D	LYS163
D	ASN191
D	ASP239
D	LYS263
D	GLY291
D	MET292
D	ILE293
D	ASP316
D	PHE323

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE NPG B 1163

Chain	Residue
A	ASP61
A	GLY62
A	HIS65
B	ASP61
B	GLY62
B	HIS65
B	ARG68
B	HIS69
B	HOH1341
B	HOH1403
B	HOH1657

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE NPG C 1164

Chain	Residue
C	ASP61
C	GLY62
C	HIS65
C	HOH1711
C	HOH1728
D	ASP61
D	GLY62
D	HIS65
D	HIS69
D	HOH1547

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:14705949, ECO:0000305|PubMed:15134446

Chain	Residue	Details
A	LYS163
B	LYS163
C	LYS163
D	LYS163

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:14705949, ECO:0000305|PubMed:15134446

Chain	Residue	Details
A	LYS263
B	LYS263
C	LYS263
D	LYS263

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:15134446, ECO:0007744|PDB:1SJB

Chain	Residue	Details
D	SER135
D	LYS161
D	ASN191
D	ILE293
A	SER135
A	LYS161
A	ASN191
A	ILE293
B	SER135
B	LYS161
B	ASN191
B	ILE293
C	SER135
C	LYS161
C	ASN191
C	ILE293

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:15134446, ECO:0000269|PubMed:23130969, ECO:0000269|Ref.9, ECO:0007744|PDB:1SJA, ECO:0007744|PDB:1SJB, ECO:0007744|PDB:1SJC, ECO:0007744|PDB:4A6G, ECO:0007744|PDB:5FJO, ECO:0007744|PDB:5FJP, ECO:0007744|PDB:5FJR, ECO:0007744|PDB:5FJT, ECO:0007744|PDB:5FJU

Chain	Residue	Details
C	ASP239
D	ASP189
D	GLU214
D	ASP239
A	ASP189
A	GLU214
A	ASP239
B	ASP189
B	GLU214
B	ASP239
C	ASP189
C	GLU214

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