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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1SHZ

Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005737cellular_componentcytoplasm
D0003924molecular_functionGTPase activity
D0005525molecular_functionGTP binding
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
D0019001molecular_functionguanyl nucleotide binding
D0031683molecular_functionG-protein beta/gamma-subunit complex binding
F0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005737cellular_componentcytoplasm
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 377
ChainResidue
ASER62
ATHR203
AALF378
AGDP475
site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D 377
ChainResidue
DSER62
DTHR203
DALF378
DGDP476
DHOH502
site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ALF A 378
ChainResidue
AGLY57
AGLU58
ALYS61
AARG200
ATHR203
AVAL223
AGLY225
AGLN226
AMG377
AGDP475
AHOH543
site_idAC4
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ALF D 378
ChainResidue
DGLY57
DGLU58
DLYS61
DARG200
DPRO202
DTHR203
DGLY225
DGLN226
DMG377
DGDP476
DHOH502
DHOH550
site_idAC5
Number of Residues17
DetailsBINDING SITE FOR RESIDUE GDP A 475
ChainResidue
AGLU58
ASER59
AGLY60
ALYS61
ASER62
ATHR63
ALEU197
ALEU198
AARG200
AASN291
ALYS292
AASP294
ALEU295
AALA348
ATHR349
AMG377
AALF378
site_idAC6
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GDP D 476
ChainResidue
DGLU58
DSER59
DGLY60
DLYS61
DSER62
DTHR63
DSER173
DLEU197
DLEU198
DARG200
DASN291
DLYS292
DASP294
DCYS347
DALA348
DTHR349
DMG377
DALF378
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues26
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues16
DetailsRegion: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues18
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues14
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues10
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16388592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18940608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CX7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18940608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CX6","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PDB","id":"1AS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N0D","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PDB","id":"1AS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GIA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FFA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N0D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18940608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CX7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q14344","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLU58
AGLN226
AARG200
ATHR203
site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DGLU58
DGLN226
DARG200
DTHR203
site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN226
site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DGLN226
site_idMCSA1
Number of Residues5
DetailsM-CSA 533
ChainResidueDetails
AGLU58electrostatic stabiliser
ATHR63electrostatic stabiliser
AARG200electrostatic stabiliser
AASP222electrostatic stabiliser
AGLN226electrostatic stabiliser
site_idMCSA2
Number of Residues5
DetailsM-CSA 533
ChainResidueDetails
CASP28electrostatic stabiliser
CASN33electrostatic stabiliser
CGLN170electrostatic stabiliser
CHIS192electrostatic stabiliser
CARG196electrostatic stabiliser

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PDB entries from 2026-01-14

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