Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005576 | cellular_component | extracellular region |
A | 0006952 | biological_process | defense response |
A | 0008200 | molecular_function | ion channel inhibitor activity |
A | 0017080 | molecular_function | sodium channel regulator activity |
A | 0019871 | molecular_function | sodium channel inhibitor activity |
A | 0044487 | biological_process | venom-mediated perturbation of transmission of nerve impulse |
A | 0044493 | biological_process | venom-mediated inhibition of voltage-gated sodium channel activity |
A | 0044742 | biological_process | venom-mediated increase of sensory perception of pain |
A | 0090729 | molecular_function | toxin activity |
A | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 165 |
Chain | Residue |
A | THR13 |
A | ASN19 |
A | TYR42 |
A | ARG58 |
A | CYS63 |
A | HOH176 |
A | HOH179 |
A | HOH191 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NO3 A 166 |
Chain | Residue |
A | LYS62 |
A | HIS64 |
A | HOH197 |
A | GLY61 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 A 167 |
Chain | Residue |
A | LYS8 |
A | THR13 |
A | PHE15 |
A | HOH178 |
A | HOH201 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PPI A 168 |
Chain | Residue |
A | PHE17 |
A | ARG18 |
A | TYR21 |
A | HOH246 |
A | HOH271 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 62 |
Details | Domain: {"description":"LCN-type CS-alpha/beta","evidences":[{"source":"PROSITE-ProRule","id":"PRU01210","evidenceCode":"ECO:0000255"}]} |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | Site: {"description":"Key residue for Nav1.7/SCN9A site 3","evidences":[{"source":"PubMed","id":"30733386","evidenceCode":"ECO:0000269"}]} |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | Modified residue: {"description":"Histidine amide","evidences":[{"source":"PubMed","id":"15725394","evidenceCode":"ECO:0000269"}]} |