1SDE
Toward Better Antibiotics: Crystal Structure Of D-Ala-D-Ala Peptidase inhibited by a novel bicyclic phosphate inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004180 | molecular_function | carboxypeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0009002 | molecular_function | serine-type D-Ala-D-Ala carboxypeptidase activity |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 2PB A 400 |
| Chain | Residue |
| A | GLY61 |
| A | VAL302 |
| A | HOH1115 |
| A | HOH1169 |
| A | HOH1231 |
| A | HOH1471 |
| A | HOH1473 |
| A | SER62 |
| A | ASP98 |
| A | TYR159 |
| A | ARG285 |
| A | HIS298 |
| A | THR299 |
| A | GLY300 |
| A | THR301 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 500 |
| Chain | Residue |
| A | SER20 |
| A | LYS80 |
| A | HIS177 |
| A | HOH1027 |
| A | HOH1032 |
| A | HOH1054 |
| A | HOH1195 |
| A | HOH1228 |
| A | HOH1346 |
| A | HOH1459 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"12215418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12564922","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15581896","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12215418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12564922","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15581896","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1ei5 |
| Chain | Residue | Details |
| A | HIS298 | |
| A | SER62 | |
| A | ASN161 | |
| A | LYS65 | |
| A | TYR159 |
