1SD8
ARSENATE REDUCTASE R60K MUTANT FROM E. COLI
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 201 |
| Chain | Residue |
| A | CYS12 |
| A | THR14 |
| A | ASN62 |
| A | ARG94 |
| A | ARG107 |
| A | HOH1001 |
| A | HOH1002 |
| A | HOH1203 |
| A | HOH1212 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 202 |
| Chain | Residue |
| A | ARG107 |
| A | HOH1096 |
| A | HOH1146 |
| A | HOH1172 |
| A | HOH1180 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 203 |
| Chain | Residue |
| A | THR14 |
| A | ASN17 |
| A | PRO108 |
| A | SER109 |
| A | LYS126 |
| A | HOH1036 |
| A | HOH1075 |
| A | HOH1168 |
| A | HOH1173 |
| A | HOH1269 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CS A 404 |
| Chain | Residue |
| A | GLY26 |
| A | THR27 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CS A 401 |
| Chain | Residue |
| A | LEU113 |
| A | LEU113 |
| A | ASP114 |
| A | ASP114 |
| A | LEU116 |
| A | LEU116 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 402 |
| Chain | Residue |
| A | GLU67 |
| A | ASP128 |
| A | HOH1075 |
| A | HOH1238 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 403 |
| Chain | Residue |
| A | PRO38 |
| A | GLU43 |
| A | HOH1021 |
| A | HOH1185 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS A 405 |
| Chain | Residue |
| A | GLU64 |
| A | GLN87 |
| A | HOH1093 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; cysteine thioarsenate intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01282","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11709171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15295115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7577935","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for activity. Lowers pKa of the active site Cys","evidences":[{"source":"PubMed","id":"8969183","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Important for activity. Involved in arsenate binding and transition-state stabilization","evidences":[{"source":"PubMed","id":"11709171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14592722","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15295115","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
