1S9K

Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00036
Number of Residues	15
Details	BZIP_BASIC Basic-leucine zipper (bZIP) domain signature. Rre.RNKmAAAKcRNR

Chain	Residue	Details
D	ARG143-ARG157
E	ARG267-ARG282

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Necessary for synergistic transcriptional activity with SMAD3

Chain	Residue	Details
E	ARG282

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:11689449

Chain	Residue	Details
E	LYS281

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PAK2 => ECO:0000269|PubMed:21177766

Chain	Residue	Details
E	THR296

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