1S9K

Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00036
Number of Residues	15
Details	BZIP_BASIC Basic-leucine zipper (bZIP) domain signature. Rre.RNKmAAAKcRNR

Chain	Residue	Details
D	ARG143-ARG157
E	ARG267-ARG282

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	DNA binding: {}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Motif: {"description":"Nuclear localization signal"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	28
Details	Region: {"description":"Leucine-zipper","evidences":[{"source":"PROSITE-ProRule","id":"PRU00978","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Necessary for synergistic transcriptional activity with SMAD3"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"11689449","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PAK2","evidences":[{"source":"PubMed","id":"21177766","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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