1S9C
Crystal structure analysis of the 2-enoyl-CoA hydratase 2 domain of human peroxisomal multifunctional enzyme type 2
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1276 |
| Details | Domain: {"description":"MaoC-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 104 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P51660","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| A | GLY216 | |
| A | ASP193 | |
| A | HIS198 | |
| A | ILE213 |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| J | GLY216 | |
| J | ASP193 | |
| J | HIS198 | |
| J | ILE213 |
| site_id | CSA11 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| K | GLY216 | |
| K | ASP193 | |
| K | HIS198 | |
| K | ILE213 |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| L | GLY216 | |
| L | ASP193 | |
| L | HIS198 | |
| L | ILE213 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| B | GLY216 | |
| B | ASP193 | |
| B | HIS198 | |
| B | ILE213 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| C | GLY216 | |
| C | ASP193 | |
| C | HIS198 | |
| C | ILE213 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| D | GLY216 | |
| D | ASP193 | |
| D | HIS198 | |
| D | ILE213 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| E | GLY216 | |
| E | ASP193 | |
| E | HIS198 | |
| E | ILE213 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| F | GLY216 | |
| F | ASP193 | |
| F | HIS198 | |
| F | ILE213 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| G | GLY216 | |
| G | ASP193 | |
| G | HIS198 | |
| G | ILE213 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| H | GLY216 | |
| H | ASP193 | |
| H | HIS198 | |
| H | ILE213 |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| I | GLY216 | |
| I | ASP193 | |
| I | HIS198 | |
| I | ILE213 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| A | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| A | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| A | ILE213 | electrostatic stabiliser |
| A | GLY216 | electrostatic stabiliser |
| site_id | MCSA10 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| J | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| J | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| J | ILE213 | electrostatic stabiliser |
| J | GLY216 | electrostatic stabiliser |
| site_id | MCSA11 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| K | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| K | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| K | ILE213 | electrostatic stabiliser |
| K | GLY216 | electrostatic stabiliser |
| site_id | MCSA12 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| L | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| L | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| L | ILE213 | electrostatic stabiliser |
| L | GLY216 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| B | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| B | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| B | ILE213 | electrostatic stabiliser |
| B | GLY216 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| C | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| C | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| C | ILE213 | electrostatic stabiliser |
| C | GLY216 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| D | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| D | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| D | ILE213 | electrostatic stabiliser |
| D | GLY216 | electrostatic stabiliser |
| site_id | MCSA5 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| E | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| E | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| E | ILE213 | electrostatic stabiliser |
| E | GLY216 | electrostatic stabiliser |
| site_id | MCSA6 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| F | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| F | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| F | ILE213 | electrostatic stabiliser |
| F | GLY216 | electrostatic stabiliser |
| site_id | MCSA7 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| G | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| G | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| G | ILE213 | electrostatic stabiliser |
| G | GLY216 | electrostatic stabiliser |
| site_id | MCSA8 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| H | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| H | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| H | ILE213 | electrostatic stabiliser |
| H | GLY216 | electrostatic stabiliser |
| site_id | MCSA9 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| I | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| I | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| I | ILE213 | electrostatic stabiliser |
| I | GLY216 | electrostatic stabiliser |
