1S9C
Crystal structure analysis of the 2-enoyl-CoA hydratase 2 domain of human peroxisomal multifunctional enzyme type 2
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS89 | |
| B | PHE246 | |
| C | HIS89 | |
| C | LYS118 | |
| C | ASP193 | |
| C | GLY216 | |
| C | PHE246 | |
| D | HIS89 | |
| D | LYS118 | |
| D | ASP193 | |
| D | GLY216 | |
| A | LYS118 | |
| D | PHE246 | |
| E | HIS89 | |
| E | LYS118 | |
| E | ASP193 | |
| E | GLY216 | |
| E | PHE246 | |
| F | HIS89 | |
| F | LYS118 | |
| F | ASP193 | |
| F | GLY216 | |
| A | ASP193 | |
| F | PHE246 | |
| G | HIS89 | |
| G | LYS118 | |
| G | ASP193 | |
| G | GLY216 | |
| G | PHE246 | |
| H | HIS89 | |
| H | LYS118 | |
| H | ASP193 | |
| H | GLY216 | |
| A | GLY216 | |
| H | PHE246 | |
| I | HIS89 | |
| I | LYS118 | |
| I | ASP193 | |
| I | GLY216 | |
| I | PHE246 | |
| J | HIS89 | |
| J | LYS118 | |
| J | ASP193 | |
| J | GLY216 | |
| A | PHE246 | |
| J | PHE246 | |
| K | HIS89 | |
| K | LYS118 | |
| K | ASP193 | |
| K | GLY216 | |
| K | PHE246 | |
| L | HIS89 | |
| L | LYS118 | |
| L | ASP193 | |
| L | GLY216 | |
| B | HIS89 | |
| L | PHE246 | |
| B | LYS118 | |
| B | ASP193 | |
| B | GLY216 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P51660 |
| Chain | Residue | Details |
| A | LYS39 | |
| D | LYS39 | |
| D | LYS107 | |
| D | LYS262 | |
| E | LYS39 | |
| E | LYS107 | |
| E | LYS262 | |
| F | LYS39 | |
| F | LYS107 | |
| F | LYS262 | |
| G | LYS39 | |
| A | LYS107 | |
| G | LYS107 | |
| G | LYS262 | |
| H | LYS39 | |
| H | LYS107 | |
| H | LYS262 | |
| I | LYS39 | |
| I | LYS107 | |
| I | LYS262 | |
| J | LYS39 | |
| J | LYS107 | |
| A | LYS262 | |
| J | LYS262 | |
| K | LYS39 | |
| K | LYS107 | |
| K | LYS262 | |
| L | LYS39 | |
| L | LYS107 | |
| L | LYS262 | |
| B | LYS39 | |
| B | LYS107 | |
| B | LYS262 | |
| C | LYS39 | |
| C | LYS107 | |
| C | LYS262 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS248 | |
| J | LYS248 | |
| K | LYS248 | |
| L | LYS248 | |
| B | LYS248 | |
| C | LYS248 | |
| D | LYS248 | |
| E | LYS248 | |
| F | LYS248 | |
| G | LYS248 | |
| H | LYS248 | |
| I | LYS248 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| A | GLY216 | |
| A | ASP193 | |
| A | HIS198 | |
| A | ILE213 |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| J | GLY216 | |
| J | ASP193 | |
| J | HIS198 | |
| J | ILE213 |
| site_id | CSA11 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| K | GLY216 | |
| K | ASP193 | |
| K | HIS198 | |
| K | ILE213 |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| L | GLY216 | |
| L | ASP193 | |
| L | HIS198 | |
| L | ILE213 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| B | GLY216 | |
| B | ASP193 | |
| B | HIS198 | |
| B | ILE213 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| C | GLY216 | |
| C | ASP193 | |
| C | HIS198 | |
| C | ILE213 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| D | GLY216 | |
| D | ASP193 | |
| D | HIS198 | |
| D | ILE213 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| E | GLY216 | |
| E | ASP193 | |
| E | HIS198 | |
| E | ILE213 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| F | GLY216 | |
| F | ASP193 | |
| F | HIS198 | |
| F | ILE213 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| G | GLY216 | |
| G | ASP193 | |
| G | HIS198 | |
| G | ILE213 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| H | GLY216 | |
| H | ASP193 | |
| H | HIS198 | |
| H | ILE213 |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 15644212, 10671535, 15051722 |
| Chain | Residue | Details |
| I | GLY216 | |
| I | ASP193 | |
| I | HIS198 | |
| I | ILE213 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| A | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| A | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| A | ILE213 | electrostatic stabiliser |
| A | GLY216 | electrostatic stabiliser |
| site_id | MCSA10 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| J | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| J | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| J | ILE213 | electrostatic stabiliser |
| J | GLY216 | electrostatic stabiliser |
| site_id | MCSA11 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| K | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| K | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| K | ILE213 | electrostatic stabiliser |
| K | GLY216 | electrostatic stabiliser |
| site_id | MCSA12 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| L | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| L | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| L | ILE213 | electrostatic stabiliser |
| L | GLY216 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| B | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| B | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| B | ILE213 | electrostatic stabiliser |
| B | GLY216 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| C | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| C | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| C | ILE213 | electrostatic stabiliser |
| C | GLY216 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| D | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| D | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| D | ILE213 | electrostatic stabiliser |
| D | GLY216 | electrostatic stabiliser |
| site_id | MCSA5 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| E | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| E | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| E | ILE213 | electrostatic stabiliser |
| E | GLY216 | electrostatic stabiliser |
| site_id | MCSA6 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| F | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| F | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| F | ILE213 | electrostatic stabiliser |
| F | GLY216 | electrostatic stabiliser |
| site_id | MCSA7 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| G | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| G | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| G | ILE213 | electrostatic stabiliser |
| G | GLY216 | electrostatic stabiliser |
| site_id | MCSA8 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| H | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| H | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| H | ILE213 | electrostatic stabiliser |
| H | GLY216 | electrostatic stabiliser |
| site_id | MCSA9 |
| Number of Residues | 4 |
| Details | M-CSA 461 |
| Chain | Residue | Details |
| I | ASP193 | electrostatic stabiliser, proton shuttle (general acid/base) |
| I | HIS198 | electrostatic stabiliser, proton shuttle (general acid/base) |
| I | ILE213 | electrostatic stabiliser |
| I | GLY216 | electrostatic stabiliser |
