1S95
Structure of serine/threonine protein phosphatase 5
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN A 501 |
| Chain | Residue |
| A | ASP242 |
| A | HIS244 |
| A | ASP271 |
| A | MN502 |
| A | PO41001 |
| A | HOH3002 |
| A | HOH3003 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN A 502 |
| Chain | Residue |
| A | HIS352 |
| A | HIS427 |
| A | MN501 |
| A | PO41001 |
| A | HOH3002 |
| A | ASP271 |
| A | ASN303 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN B 601 |
| Chain | Residue |
| B | ASP242 |
| B | HIS244 |
| B | ASP271 |
| B | MN602 |
| B | PO42001 |
| B | HOH3003 |
| B | HOH3004 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN B 602 |
| Chain | Residue |
| B | ASP271 |
| B | ASN303 |
| B | HIS352 |
| B | HIS427 |
| B | MN601 |
| B | PO42001 |
| B | HOH3003 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1001 |
| Chain | Residue |
| A | HIS244 |
| A | ASP271 |
| A | ARG275 |
| A | ASN303 |
| A | HIS304 |
| A | ARG400 |
| A | HIS427 |
| A | MN501 |
| A | MN502 |
| A | HOH3002 |
| A | HOH3003 |
| A | HOH3175 |
| A | HOH3182 |
| B | MET499 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PO4 B 2001 |
| Chain | Residue |
| B | HIS244 |
| B | ASP271 |
| B | ARG275 |
| B | ASN303 |
| B | HIS304 |
| B | ARG400 |
| B | HIS427 |
| B | MN601 |
| B | MN602 |
| B | HOH3003 |
| B | HOH3004 |
| B | HOH3087 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD A 3001 |
| Chain | Residue |
| A | LYS192 |
| A | LEU251 |
| A | GLU255 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD B 3002 |
| Chain | Residue |
| B | LYS192 |
| B | GLN196 |
| B | GLU255 |
Functional Information from PROSITE/UniProt
| site_id | PS00125 |
| Number of Residues | 6 |
| Details | SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE |
| Chain | Residue | Details |
| A | LEU300-GLU305 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 630 |
| Details | Region: {"description":"Catalytic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"Required for autoinhibition","evidences":[{"source":"UniProtKB","id":"P53042","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15577939","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19601647","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1S95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H60","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H64","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 15155720 |
| Chain | Residue | Details |
| A | HIS304 | |
| A | ASP274 | |
| A | ARG400 | |
| A | ARG275 | |
| A | ASN303 | |
| A | HIS427 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 15155720 |
| Chain | Residue | Details |
| B | HIS304 | |
| B | ASP274 | |
| B | ARG400 | |
| B | ARG275 | |
| B | ASN303 | |
| B | HIS427 |
| site_id | MCSA1 |
| Number of Residues | 10 |
| Details | M-CSA 472 |
| Chain | Residue | Details |
| A | ASP242 | metal ligand |
| A | HIS427 | activator, metal ligand |
| A | HIS244 | metal ligand |
| A | ASP271 | metal ligand |
| A | ASP274 | activator, proton donor |
| A | ARG275 | transition state stabiliser |
| A | ASN303 | metal ligand, transition state stabiliser |
| A | HIS304 | proton acceptor, proton donor, proton relay |
| A | HIS352 | metal ligand |
| A | ARG400 | transition state stabiliser |
| site_id | MCSA2 |
| Number of Residues | 10 |
| Details | M-CSA 472 |
| Chain | Residue | Details |
| B | ASP242 | metal ligand |
| B | HIS427 | activator, metal ligand |
| B | HIS244 | metal ligand |
| B | ASP271 | metal ligand |
| B | ASP274 | activator, proton donor |
| B | ARG275 | transition state stabiliser |
| B | ASN303 | metal ligand, transition state stabiliser |
| B | HIS304 | proton acceptor, proton donor, proton relay |
| B | HIS352 | metal ligand |
| B | ARG400 | transition state stabiliser |
