1S8C

Crystal structure of human heme oxygenase in a complex with biliverdine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004392	molecular_function	heme oxygenase (decyclizing) activity
A	0006788	biological_process	heme oxidation
B	0004392	molecular_function	heme oxygenase (decyclizing) activity
B	0006788	biological_process	heme oxidation
C	0004392	molecular_function	heme oxygenase (decyclizing) activity
C	0006788	biological_process	heme oxidation
D	0004392	molecular_function	heme oxygenase (decyclizing) activity
D	0006788	biological_process	heme oxidation

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE BLA A 400

Chain	Residue
A	GLU29
A	GLY139
A	ASP140
A	GLY143
A	GLY144
A	LEU147
A	PHE166
A	PHE167
A	PHE207
A	ASN210
A	LEU213
A	MET34
A	PHE214
A	LEU217
A	HOH442
A	HOH451
A	GLN38
A	VAL50
A	SER53
A	LEU54
A	ILE57
A	THR135
A	ARG136

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Functional Information from PROSITE/UniProt

site_id	PS00593
Number of Residues	11
Details	HEME_OXYGENASE Heme oxygenase signature. LVAHAYTRYLG

Chain	Residue	Details
A	LEU129-GLY139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:12842469, ECO:0007744|PDB:1OZW

Chain	Residue	Details
A	LYS18
D	LYS18
D	TYR134
D	ARG183
A	TYR134
A	ARG183
B	LYS18
B	TYR134
B	ARG183
C	LYS18
C	TYR134
C	ARG183

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000269|PubMed:12842469, ECO:0007744|PDB:1OZW

Chain	Residue	Details
A	HIS25
B	HIS25
C	HIS25
D	HIS25

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Important for catalytic activity => ECO:0000269|PubMed:11121422

Chain	Residue	Details
A	ASP140
B	ASP140
C	ASP140
D	ASP140

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER229
B	SER229
C	SER229
D	SER229

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	7
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
A	ARG136
A	TYR58
A	THR135
A	ASP140
A	GLY143
A	HIS25
A	GLY139

---

site_id	CSA2
Number of Residues	7
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
B	ARG136
B	TYR58
B	THR135
B	ASP140
B	GLY143
B	HIS25
B	GLY139

---

site_id	CSA3
Number of Residues	7
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
C	ARG136
C	TYR58
C	THR135
C	ASP140
C	GLY143
C	HIS25
C	GLY139

---

site_id	CSA4
Number of Residues	7
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
D	ARG136
D	TYR58
D	THR135
D	ASP140
D	GLY143
D	HIS25
D	GLY139

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
A	ASP140
A	GLY144

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
B	ASP140
B	GLY144

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
C	ASP140
C	GLY144

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site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
D	ASP140
D	GLY144

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