1S50

X-ray structure of the GluR6 ligand binding core (S1S2A) in complex with glutamate at 1.65 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 999

Chain	Residue
A	TYR61
A	HOH1001
A	HOH1005
A	HOH1009
A	HOH1017
A	PRO89
A	LEU90
A	ALA91
A	ARG96
A	GLY141
A	ALA142
A	THR143
A	GLU191

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	TYR135-TYR155
A	ILE212-THR232

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site_id	SWS_FT_FI2
Number of Residues	55
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:8163463

Chain	Residue	Details
A	ASP156-LEU211

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:15721240, ECO:0000269|PubMed:17115050, ECO:0007744|PDB:1S50, ECO:0007744|PDB:1S7Y, ECO:0007744|PDB:2I0B, ECO:0007744|PDB:2I0C

Chain	Residue	Details
A	PRO89
A	ALA91
A	ARG96
A	ALA142
A	THR143
A	GLU191

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
A	THR119

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15677325, ECO:0000269|PubMed:8163463

Chain	Residue	Details
A	ASN204

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