Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1S4E

Pyrococcus furiosus galactokinase in complex with galactose, ADP and magnesium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004335	molecular_function	galactokinase activity
A	0005524	molecular_function	ATP binding
A	0005534	molecular_function	galactose binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005996	biological_process	monosaccharide metabolic process
A	0006012	biological_process	galactose metabolic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0046835	biological_process	carbohydrate phosphorylation
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004335	molecular_function	galactokinase activity
B	0005524	molecular_function	ATP binding
B	0005534	molecular_function	galactose binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005996	biological_process	monosaccharide metabolic process
B	0006012	biological_process	galactose metabolic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0046835	biological_process	carbohydrate phosphorylation
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004335	molecular_function	galactokinase activity
C	0005524	molecular_function	ATP binding
C	0005534	molecular_function	galactose binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005996	biological_process	monosaccharide metabolic process
C	0006012	biological_process	galactose metabolic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
C	0046835	biological_process	carbohydrate phosphorylation
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0004335	molecular_function	galactokinase activity
D	0005524	molecular_function	ATP binding
D	0005534	molecular_function	galactose binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005996	biological_process	monosaccharide metabolic process
D	0006012	biological_process	galactose metabolic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
D	0046835	biological_process	carbohydrate phosphorylation
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0004335	molecular_function	galactokinase activity
E	0005524	molecular_function	ATP binding
E	0005534	molecular_function	galactose binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005996	biological_process	monosaccharide metabolic process
E	0006012	biological_process	galactose metabolic process
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
E	0046835	biological_process	carbohydrate phosphorylation
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0004335	molecular_function	galactokinase activity
F	0005524	molecular_function	ATP binding
F	0005534	molecular_function	galactose binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005996	biological_process	monosaccharide metabolic process
F	0006012	biological_process	galactose metabolic process
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
F	0046835	biological_process	carbohydrate phosphorylation
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0004335	molecular_function	galactokinase activity
G	0005524	molecular_function	ATP binding
G	0005534	molecular_function	galactose binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005996	biological_process	monosaccharide metabolic process
G	0006012	biological_process	galactose metabolic process
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
G	0046835	biological_process	carbohydrate phosphorylation
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0004335	molecular_function	galactokinase activity
H	0005524	molecular_function	ATP binding
H	0005534	molecular_function	galactose binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005996	biological_process	monosaccharide metabolic process
H	0006012	biological_process	galactose metabolic process
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
H	0046835	biological_process	carbohydrate phosphorylation
H	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0004335	molecular_function	galactokinase activity
I	0005524	molecular_function	ATP binding
I	0005534	molecular_function	galactose binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005996	biological_process	monosaccharide metabolic process
I	0006012	biological_process	galactose metabolic process
I	0016301	molecular_function	kinase activity
I	0016740	molecular_function	transferase activity
I	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
I	0046835	biological_process	carbohydrate phosphorylation
I	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00106
Number of Residues	12
Details	GALACTOKINASE Galactokinase signature. GRvNLIGEHtDY

Chain	Residue	Details
A	GLY10-TYR21

site_id	PS00627
Number of Residues	12
Details	GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. LPlGaGLSSSAS

Chain	Residue	Details
A	LEU98-SER109

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:15003454

Chain	Residue	Details
A	ASP151
B	ASP151
C	ASP151
D	ASP151
E	ASP151
F	ASP151
G	ASP151
H	ASP151
I	ASP151

site_id	SWS_FT_FI2
Number of Residues	27
Details	BINDING: BINDING => ECO:0000269\|PubMed:15003454

Chain	Residue	Details
A	GLU17
D	GLU17
D	SER107
D	GLU139
E	GLU17
E	SER107
E	GLU139
F	GLU17
F	SER107
F	GLU139
G	GLU17
A	SER107
G	SER107
G	GLU139
H	GLU17
H	SER107
H	GLU139
I	GLU17
I	SER107
I	GLU139
A	GLU139
B	GLU17
B	SER107
B	GLU139
C	GLU17
C	SER107
C	GLU139

site_id	SWS_FT_FI3
Number of Residues	18
Details	BINDING: BINDING => ECO:0000305\|PubMed:15003454

Chain	Residue	Details
A	SER49
E	GLY101
F	SER49
F	GLY101
G	SER49
G	GLY101
H	SER49
H	GLY101
I	SER49
I	GLY101
A	GLY101
B	SER49
B	GLY101
C	SER49
C	GLY101
D	SER49
D	GLY101
E	SER49

site_id	SWS_FT_FI4
Number of Residues	9
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00246, ECO:0000269\|PubMed:15003454

Chain	Residue	Details
A	TYR200
B	TYR200
C	TYR200
D	TYR200
E	TYR200
F	TYR200
G	TYR200
H	TYR200
I	TYR200

site_id	SWS_FT_FI5
Number of Residues	9
Details	SITE: Transition state stabilizer => ECO:0000305\|PubMed:15003454

Chain	Residue	Details
A	ARG11
B	ARG11
C	ARG11
D	ARG11
E	ARG11
F	ARG11
G	ARG11
H	ARG11
I	ARG11

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
A	LEU195

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
B	SER197

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
C	SER197

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
D	SER197

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
E	SER197

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
F	SER197

site_id	CSA15
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
G	SER197

site_id	CSA16
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
H	SER197

site_id	CSA17
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
I	SER197

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
B	LEU195

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
C	LEU195

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
D	LEU195

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
E	LEU195

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
F	LEU195

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
H	LEU195

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
I	LEU195

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
A	SER197

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)