1S3Z
Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and Ribostamycin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006084 | biological_process | acetyl-CoA metabolic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0047663 | molecular_function | aminoglycoside 6'-N-acetyltransferase activity |
| B | 0006084 | biological_process | acetyl-CoA metabolic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0047663 | molecular_function | aminoglycoside 6'-N-acetyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI A 700 |
| Chain | Residue |
| A | HIS0 |
| A | ASP2 |
| A | HIS42 |
| A | HIS64 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 800 |
| Chain | Residue |
| A | HOH872 |
| A | THR116 |
| A | SER117 |
| A | ASN120 |
| A | RIO500 |
| A | COA600 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 801 |
| Chain | Residue |
| B | ASP115 |
| B | THR116 |
| B | SER117 |
| B | ASN120 |
| B | RIO501 |
| B | COA601 |
| B | HOH840 |
| B | HOH870 |
| B | HOH875 |
| B | HOH908 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE COA A 600 |
| Chain | Residue |
| A | ILE81 |
| A | PHE82 |
| A | VAL83 |
| A | ARG88 |
| A | GLN89 |
| A | ARG90 |
| A | GLY91 |
| A | VAL92 |
| A | ALA93 |
| A | LYS94 |
| A | ASN120 |
| A | ILE122 |
| A | SER123 |
| A | LYS125 |
| A | VAL126 |
| A | ALA129 |
| A | RIO500 |
| A | SO4800 |
| A | HOH801 |
| A | HOH809 |
| A | HOH836 |
| A | HOH837 |
| A | HOH882 |
| A | HOH895 |
| B | ARG110 |
| B | HOH845 |
| B | HOH900 |
| site_id | AC5 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE COA B 601 |
| Chain | Residue |
| B | ILE81 |
| B | PHE82 |
| B | VAL83 |
| B | ARG88 |
| B | GLN89 |
| B | ARG90 |
| B | GLY91 |
| B | VAL92 |
| B | ALA93 |
| B | LYS94 |
| B | ASN120 |
| B | ILE122 |
| B | SER123 |
| B | VAL126 |
| B | ALA129 |
| B | RIO501 |
| B | SO4801 |
| B | HOH812 |
| B | HOH813 |
| B | HOH829 |
| B | HOH836 |
| B | HOH853 |
| B | HOH856 |
| B | HOH876 |
| B | HOH884 |
| B | HOH910 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE RIO A 500 |
| Chain | Residue |
| A | TRP22 |
| A | HIS25 |
| A | GLU79 |
| A | ASP115 |
| A | COA600 |
| A | SO4800 |
| A | HOH819 |
| A | HOH820 |
| A | HOH828 |
| A | HOH838 |
| A | HOH842 |
| A | HOH866 |
| A | HOH879 |
| B | LYS8 |
| B | TYR66 |
| B | ASN68 |
| B | GLU136 |
| site_id | AC7 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE RIO B 501 |
| Chain | Residue |
| B | COA601 |
| B | SO4801 |
| B | HOH809 |
| B | HOH810 |
| B | HOH811 |
| B | HOH816 |
| B | HOH827 |
| B | HOH840 |
| B | HOH846 |
| B | HOH850 |
| B | HOH859 |
| B | HOH904 |
| A | TYR66 |
| A | GLU136 |
| A | VAL138 |
| B | ARG18 |
| B | TRP22 |
| B | HIS25 |
| B | GLU79 |
| B | ASP115 |
| B | THR116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15123251 |
| Chain | Residue | Details |
| A | TRP22 | |
| B | TRP22 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15123251, ECO:0000269|PubMed:18095712 |
| Chain | Residue | Details |
| A | HIS25 | |
| B | TYR66 | |
| B | GLU79 | |
| B | ILE81 | |
| B | GLN89 | |
| B | ASP115 | |
| B | ASN120 | |
| B | GLU136 | |
| A | TYR66 | |
| A | GLU79 | |
| A | ILE81 | |
| A | GLN89 | |
| A | ASP115 | |
| A | ASN120 | |
| A | GLU136 | |
| B | HIS25 |
