1S3D
ARSENATE REDUCTASE R60A MUTANT FROM E. COLI
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 201 |
| Chain | Residue |
| A | CYS12 |
| A | HOH1188 |
| A | GLY13 |
| A | THR14 |
| A | ASN62 |
| A | ARG94 |
| A | ARG107 |
| A | HOH1064 |
| A | HOH1088 |
| A | HOH1100 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 202 |
| Chain | Residue |
| A | ASN93 |
| A | ARG107 |
| A | HOH1125 |
| A | HOH1234 |
| A | HOH1235 |
| A | HOH1240 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 203 |
| Chain | Residue |
| A | THR14 |
| A | ASN17 |
| A | PRO108 |
| A | SER109 |
| A | LYS126 |
| A | HOH1033 |
| A | HOH1077 |
| A | HOH1195 |
| A | HOH1229 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 204 |
| Chain | Residue |
| A | HIS88 |
| A | HOH1087 |
| A | HOH1165 |
| A | HOH1171 |
| A | HOH1173 |
| A | HOH1194 |
| A | HOH1273 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CS A 401 |
| Chain | Residue |
| A | LEU113 |
| A | LEU113 |
| A | ASP114 |
| A | ASP114 |
| A | LEU116 |
| A | LEU116 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CS A 402 |
| Chain | Residue |
| A | PRO38 |
| A | GLU43 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CS A 403 |
| Chain | Residue |
| A | GLU64 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CS A 404 |
| Chain | Residue |
| A | GLN120 |
| A | GLU135 |
| A | HOH1119 |
| A | HOH1183 |
| A | HOH1301 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 405 |
| Chain | Residue |
| A | GLU67 |
| A | ASP128 |
| A | HOH1077 |
| A | HOH1209 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; cysteine thioarsenate intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01282","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11709171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15295115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7577935","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for activity. Lowers pKa of the active site Cys","evidences":[{"source":"PubMed","id":"8969183","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Important for activity. Involved in arsenate binding and transition-state stabilization","evidences":[{"source":"PubMed","id":"11709171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14592722","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15295115","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
