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1RXD

Crystal structure of human protein tyrosine phosphatase 4A1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004721molecular_functionphosphoprotein phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005783cellular_componentendoplasmic reticulum
A0005819cellular_componentspindle
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006470biological_processprotein dephosphorylation
A0009898cellular_componentcytoplasmic side of plasma membrane
A0016311biological_processdephosphorylation
A0030335biological_processpositive regulation of cell migration
B0004721molecular_functionphosphoprotein phosphatase activity
B0004725molecular_functionprotein tyrosine phosphatase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005783cellular_componentendoplasmic reticulum
B0005819cellular_componentspindle
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006470biological_processprotein dephosphorylation
B0009898cellular_componentcytoplasmic side of plasma membrane
B0016311biological_processdephosphorylation
B0030335biological_processpositive regulation of cell migration
C0004721molecular_functionphosphoprotein phosphatase activity
C0004725molecular_functionprotein tyrosine phosphatase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005783cellular_componentendoplasmic reticulum
C0005819cellular_componentspindle
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006470biological_processprotein dephosphorylation
C0009898cellular_componentcytoplasmic side of plasma membrane
C0016311biological_processdephosphorylation
C0030335biological_processpositive regulation of cell migration
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Proton donor => ECO:0000305
ChainResidueDetails
AASP71
BASP71
CASP71

site_idSWS_FT_FI2
Number of Residues3
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160
ChainResidueDetails
ACYS103
BCYS103
CCYS103

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING:
ChainResidueDetails
AVAL104
AARG109
BVAL104
BARG109
CVAL104
CARG109

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1d5r
ChainResidueDetails
ACYS103
AARG109

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1d5r
ChainResidueDetails
BARG109
BCYS103
BASP71

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1d5r
ChainResidueDetails
CCYS103
CARG109

224201

PDB entries from 2024-08-28

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