Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1RXC

E. COLI uridine phosphorylase: 5-fluorouracil ribose-1-phosphate complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006218	biological_process	uridine catabolic process
A	0006974	biological_process	DNA damage response
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016763	molecular_function	pentosyltransferase activity
A	0030955	molecular_function	potassium ion binding
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0044206	biological_process	UMP salvage
A	0046050	biological_process	UMP catabolic process
B	0003824	molecular_function	catalytic activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006218	biological_process	uridine catabolic process
B	0006974	biological_process	DNA damage response
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016763	molecular_function	pentosyltransferase activity
B	0030955	molecular_function	potassium ion binding
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0044206	biological_process	UMP salvage
B	0046050	biological_process	UMP catabolic process
C	0003824	molecular_function	catalytic activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006218	biological_process	uridine catabolic process
C	0006974	biological_process	DNA damage response
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016763	molecular_function	pentosyltransferase activity
C	0030955	molecular_function	potassium ion binding
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0044206	biological_process	UMP salvage
C	0046050	biological_process	UMP catabolic process
D	0003824	molecular_function	catalytic activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006218	biological_process	uridine catabolic process
D	0006974	biological_process	DNA damage response
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016763	molecular_function	pentosyltransferase activity
D	0030955	molecular_function	potassium ion binding
D	0032991	cellular_component	protein-containing complex
D	0042802	molecular_function	identical protein binding
D	0044206	biological_process	UMP salvage
D	0046050	biological_process	UMP catabolic process
E	0003824	molecular_function	catalytic activity
E	0004850	molecular_function	uridine phosphorylase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006218	biological_process	uridine catabolic process
E	0006974	biological_process	DNA damage response
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0009166	biological_process	nucleotide catabolic process
E	0016763	molecular_function	pentosyltransferase activity
E	0030955	molecular_function	potassium ion binding
E	0032991	cellular_component	protein-containing complex
E	0042802	molecular_function	identical protein binding
E	0044206	biological_process	UMP salvage
E	0046050	biological_process	UMP catabolic process
F	0003824	molecular_function	catalytic activity
F	0004850	molecular_function	uridine phosphorylase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006218	biological_process	uridine catabolic process
F	0006974	biological_process	DNA damage response
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0009166	biological_process	nucleotide catabolic process
F	0016763	molecular_function	pentosyltransferase activity
F	0030955	molecular_function	potassium ion binding
F	0032991	cellular_component	protein-containing complex
F	0042802	molecular_function	identical protein binding
F	0044206	biological_process	UMP salvage
F	0046050	biological_process	UMP catabolic process
G	0003824	molecular_function	catalytic activity
G	0004850	molecular_function	uridine phosphorylase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006218	biological_process	uridine catabolic process
G	0006974	biological_process	DNA damage response
G	0009116	biological_process	nucleoside metabolic process
G	0009164	biological_process	nucleoside catabolic process
G	0009166	biological_process	nucleotide catabolic process
G	0016763	molecular_function	pentosyltransferase activity
G	0030955	molecular_function	potassium ion binding
G	0032991	cellular_component	protein-containing complex
G	0042802	molecular_function	identical protein binding
G	0044206	biological_process	UMP salvage
G	0046050	biological_process	UMP catabolic process
H	0003824	molecular_function	catalytic activity
H	0004850	molecular_function	uridine phosphorylase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006218	biological_process	uridine catabolic process
H	0006974	biological_process	DNA damage response
H	0009116	biological_process	nucleoside metabolic process
H	0009164	biological_process	nucleoside catabolic process
H	0009166	biological_process	nucleotide catabolic process
H	0016763	molecular_function	pentosyltransferase activity
H	0030955	molecular_function	potassium ion binding
H	0032991	cellular_component	protein-containing complex
H	0042802	molecular_function	identical protein binding
H	0044206	biological_process	UMP salvage
H	0046050	biological_process	UMP catabolic process
I	0003824	molecular_function	catalytic activity
I	0004850	molecular_function	uridine phosphorylase activity
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006218	biological_process	uridine catabolic process
I	0006974	biological_process	DNA damage response
I	0009116	biological_process	nucleoside metabolic process
I	0009164	biological_process	nucleoside catabolic process
I	0009166	biological_process	nucleotide catabolic process
I	0016763	molecular_function	pentosyltransferase activity
I	0030955	molecular_function	potassium ion binding
I	0032991	cellular_component	protein-containing complex
I	0042802	molecular_function	identical protein binding
I	0044206	biological_process	UMP salvage
I	0046050	biological_process	UMP catabolic process
J	0003824	molecular_function	catalytic activity
J	0004850	molecular_function	uridine phosphorylase activity
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006218	biological_process	uridine catabolic process
J	0006974	biological_process	DNA damage response
J	0009116	biological_process	nucleoside metabolic process
J	0009164	biological_process	nucleoside catabolic process
J	0009166	biological_process	nucleotide catabolic process
J	0016763	molecular_function	pentosyltransferase activity
J	0030955	molecular_function	potassium ion binding
J	0032991	cellular_component	protein-containing complex
J	0042802	molecular_function	identical protein binding
J	0044206	biological_process	UMP salvage
J	0046050	biological_process	UMP catabolic process
K	0003824	molecular_function	catalytic activity
K	0004850	molecular_function	uridine phosphorylase activity
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006218	biological_process	uridine catabolic process
K	0006974	biological_process	DNA damage response
K	0009116	biological_process	nucleoside metabolic process
K	0009164	biological_process	nucleoside catabolic process
K	0009166	biological_process	nucleotide catabolic process
K	0016763	molecular_function	pentosyltransferase activity
K	0030955	molecular_function	potassium ion binding
K	0032991	cellular_component	protein-containing complex
K	0042802	molecular_function	identical protein binding
K	0044206	biological_process	UMP salvage
K	0046050	biological_process	UMP catabolic process
L	0003824	molecular_function	catalytic activity
L	0004850	molecular_function	uridine phosphorylase activity
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006218	biological_process	uridine catabolic process
L	0006974	biological_process	DNA damage response
L	0009116	biological_process	nucleoside metabolic process
L	0009164	biological_process	nucleoside catabolic process
L	0009166	biological_process	nucleotide catabolic process
L	0016763	molecular_function	pentosyltransferase activity
L	0030955	molecular_function	potassium ion binding
L	0032991	cellular_component	protein-containing complex
L	0042802	molecular_function	identical protein binding
L	0044206	biological_process	UMP salvage
L	0046050	biological_process	UMP catabolic process

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL

Chain	Residue	Details
A	SER66-LEU81

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
A	GLU80
A	HIS8
A	ARG223

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
J	GLU80
J	HIS8
J	ARG223

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
K	GLU80
K	HIS8
K	ARG223

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
L	GLU80
L	HIS8
L	ARG223

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
B	GLU80
B	HIS8
B	ARG223

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
C	GLU80
C	HIS8
C	ARG223

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
D	GLU80
D	HIS8
D	ARG223

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
E	GLU80
E	HIS8
E	ARG223

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
F	GLU80
F	HIS8
F	ARG223

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
G	GLU80
G	HIS8
G	ARG223

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
H	GLU80
H	HIS8
H	ARG223

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
I	GLU80
I	HIS8
I	ARG223

site_id	MCSA1
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
A	HIS8	proton acceptor, proton donor
A	GLU80	electrostatic stabiliser, polar interaction
A	ARG168	proton acceptor, proton donor
A	ARG223	electrostatic stabiliser, polar interaction

site_id	MCSA10
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
J	HIS8	proton acceptor, proton donor
J	GLU80	electrostatic stabiliser, polar interaction
J	ARG168	proton acceptor, proton donor
J	ARG223	electrostatic stabiliser, polar interaction

site_id	MCSA11
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
K	HIS8	proton acceptor, proton donor
K	GLU80	electrostatic stabiliser, polar interaction
K	ARG168	proton acceptor, proton donor
K	ARG223	electrostatic stabiliser, polar interaction

site_id	MCSA12
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
L	HIS8	proton acceptor, proton donor
L	GLU80	electrostatic stabiliser, polar interaction
L	ARG168	proton acceptor, proton donor
L	ARG223	electrostatic stabiliser, polar interaction

site_id	MCSA2
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
B	HIS8	proton acceptor, proton donor
B	GLU80	electrostatic stabiliser, polar interaction
B	ARG168	proton acceptor, proton donor
B	ARG223	electrostatic stabiliser, polar interaction

site_id	MCSA3
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
C	HIS8	proton acceptor, proton donor
C	GLU80	electrostatic stabiliser, polar interaction
C	ARG168	proton acceptor, proton donor
C	ARG223	electrostatic stabiliser, polar interaction

site_id	MCSA4
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
D	HIS8	proton acceptor, proton donor
D	GLU80	electrostatic stabiliser, polar interaction
D	ARG168	proton acceptor, proton donor
D	ARG223	electrostatic stabiliser, polar interaction

site_id	MCSA5
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
E	HIS8	proton acceptor, proton donor
E	GLU80	electrostatic stabiliser, polar interaction
E	ARG168	proton acceptor, proton donor
E	ARG223	electrostatic stabiliser, polar interaction

site_id	MCSA6
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
F	HIS8	proton acceptor, proton donor
F	GLU80	electrostatic stabiliser, polar interaction
F	ARG168	proton acceptor, proton donor
F	ARG223	electrostatic stabiliser, polar interaction

site_id	MCSA7
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
G	HIS8	proton acceptor, proton donor
G	GLU80	electrostatic stabiliser, polar interaction
G	ARG168	proton acceptor, proton donor
G	ARG223	electrostatic stabiliser, polar interaction

site_id	MCSA8
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
H	HIS8	proton acceptor, proton donor
H	GLU80	electrostatic stabiliser, polar interaction
H	ARG168	proton acceptor, proton donor
H	ARG223	electrostatic stabiliser, polar interaction

site_id	MCSA9
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
I	HIS8	proton acceptor, proton donor
I	GLU80	electrostatic stabiliser, polar interaction
I	ARG168	proton acceptor, proton donor
I	ARG223	electrostatic stabiliser, polar interaction

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)