1RV8
Class II fructose-1,6-bisphosphate aldolase from Thermus aquaticus in complex with cobalt
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016832 | molecular_function | aldehyde-lyase activity |
| A | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016832 | molecular_function | aldehyde-lyase activity |
| B | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006096 | biological_process | glycolytic process |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016832 | molecular_function | aldehyde-lyase activity |
| C | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006096 | biological_process | glycolytic process |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016832 | molecular_function | aldehyde-lyase activity |
| D | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1601 |
| Chain | Residue |
| A | ARG278 |
| B | SER49 |
| B | GLY51 |
| B | ARG257 |
| B | HOH1742 |
| B | HOH1866 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1602 |
| Chain | Residue |
| B | THR254 |
| B | HOH1763 |
| B | HOH1827 |
| B | HOH1916 |
| B | SER211 |
| B | ASN251 |
| B | ASP253 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1603 |
| Chain | Residue |
| A | SER49 |
| A | GLY51 |
| A | HOH1770 |
| A | HOH1883 |
| A | HOH1885 |
| B | ARG278 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1604 |
| Chain | Residue |
| A | HIS178 |
| A | GLY179 |
| A | LYS182 |
| A | GLY209 |
| A | ALA210 |
| A | SER211 |
| A | ASP253 |
| A | THR254 |
| A | HOH1753 |
| A | HOH1868 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1605 |
| Chain | Residue |
| C | ARG278 |
| D | SER49 |
| D | GLY51 |
| D | ARG257 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1606 |
| Chain | Residue |
| D | GLY209 |
| D | SER211 |
| D | ASN251 |
| D | ASP253 |
| D | THR254 |
| D | HOH1747 |
| D | HOH1844 |
| D | HOH1947 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1607 |
| Chain | Residue |
| C | SER49 |
| C | ARG257 |
| C | HOH1751 |
| D | ARG278 |
| D | HOH1859 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1608 |
| Chain | Residue |
| C | GLY209 |
| C | ALA210 |
| C | SER211 |
| C | ASN251 |
| C | ASP253 |
| C | THR254 |
| C | HOH1777 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1609 |
| Chain | Residue |
| C | ARG116 |
| C | HIS123 |
| C | HOH1754 |
| C | HOH1761 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1610 |
| Chain | Residue |
| B | ARG116 |
| B | HIS123 |
| B | GLY166 |
| B | HOH1788 |
| B | HOH1851 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1611 |
| Chain | Residue |
| D | ARG116 |
| D | HIS123 |
| D | HOH1881 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1612 |
| Chain | Residue |
| A | ARG116 |
| A | VAL119 |
| A | HIS123 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO B 1701 |
| Chain | Residue |
| B | HIS81 |
| B | GLU132 |
| B | HIS178 |
| B | HIS208 |
| B | HOH1750 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 1702 |
| Chain | Residue |
| B | HIS78 |
| B | ASP80 |
| B | GLU130 |
| B | LYS249 |
| B | ASN251 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO A 1703 |
| Chain | Residue |
| A | HIS81 |
| A | HIS178 |
| A | HIS208 |
| A | CO1709 |
| A | HOH1918 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NA A 1704 |
| Chain | Residue |
| A | HIS78 |
| A | ASP80 |
| A | MET100 |
| A | GLU130 |
| A | HIS208 |
| A | LYS249 |
| A | ASN251 |
| A | HOH1712 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO D 1705 |
| Chain | Residue |
| D | HIS81 |
| D | GLU132 |
| D | HIS178 |
| D | HIS208 |
| D | HOH1751 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA D 1706 |
| Chain | Residue |
| D | HIS208 |
| D | LYS249 |
| D | ASN251 |
| D | HOH1716 |
| D | HIS78 |
| D | ASP80 |
| D | GLU130 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO C 1707 |
| Chain | Residue |
| C | HIS81 |
| C | GLU132 |
| C | HIS178 |
| C | HIS208 |
| C | HOH1729 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA C 1708 |
| Chain | Residue |
| C | HIS78 |
| C | ASP80 |
| C | GLU130 |
| C | HIS208 |
| C | LYS249 |
| C | ASN251 |
| C | HOH1709 |
| site_id | CC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CO A 1709 |
| Chain | Residue |
| A | HIS81 |
| A | GLU132 |
| A | LEU136 |
| A | HIS178 |
| A | HIS208 |
| A | CO1703 |
| A | HOH1937 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1b57 |
| Chain | Residue | Details |
| A | ASP80 | |
| A | ASN251 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b57 |
| Chain | Residue | Details |
| B | ASP80 | |
| B | ASN251 | |
| B | GLU140 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b57 |
| Chain | Residue | Details |
| C | ASP80 | |
| C | ASN251 | |
| C | GLU140 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b57 |
| Chain | Residue | Details |
| D | ASP80 | |
| D | ASN251 | |
| D | GLU140 |
