1RTU

USTILAGO SPHAEROGENA RIBONUCLEASE U2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004519	molecular_function	endonuclease activity
A	0004521	molecular_function	RNA endonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0016829	molecular_function	lyase activity
A	0033899	molecular_function	ribonuclease U2 activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 201

Chain	Residue
A	HIS101
A	PHE110
A	HOH396
A	TYR39
A	HIS41
A	GLU62
A	ARG85

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site_id	CAT
Number of Residues	5
Details	CATALYTIC SITE.

Chain	Residue
A	TYR39
A	HIS41
A	GLU62
A	ARG85
A	HIS101

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000269|Ref.5

Chain	Residue	Details
A	HIS41

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000269|Ref.5

Chain	Residue	Details
A	GLU62

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site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000269|Ref.5

Chain	Residue	Details
A	HIS101

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site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20858208

Chain	Residue	Details
A	ASP29
A	VAL30
A	ALA31
A	ASN32
A	ASP37
A	TYR39

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site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	ARG85
A	ASP108

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site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Methylation inactivates enzyme => ECO:0000269|PubMed:7492561

Chain	Residue	Details
A	GLU62

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details

Chain	Residue	Details
A	GLU62
A	HIS101
A	HIS41

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 908

Chain	Residue	Details
A	HIS41	proton shuttle (general acid/base)
A	GLU62	proton shuttle (general acid/base)
A	ARG85	electrostatic stabiliser
A	HIS101	proton shuttle (general acid/base)

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