1RP4

Structure of Ero1p, Source of Disulfide Bonds for Oxidative Protein Folding in the Cell

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005783	cellular_component	endoplasmic reticulum
A	0015035	molecular_function	protein-disulfide reductase activity
A	0016972	molecular_function	thiol oxidase activity
A	0034975	biological_process	protein folding in endoplasmic reticulum
A	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 801

Chain	Residue
A	GLU64
A	HIS386
A	GLU411
A	HOH832

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 802

Chain	Residue
A	LYS240
A	GLU241
A	GLU408
A	HOH886

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NEN A 501

Chain	Residue
A	ARG423
A	LEU424
A	CYS208

---

site_id	AC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE FAD A 634

Chain	Residue
A	VAL107
A	GLU186
A	ARG187
A	PHE188
A	THR189
A	TYR191
A	ALA196
A	ILE199
A	TRP200
A	TYR204
A	TYR224
A	SER228
A	HIS231
A	ALA232
A	ILE234
A	LEU238
A	ARG260
A	ARG267
A	MSE347
A	CYS355
A	HOH805
A	HOH810
A	HOH819
A	HOH844
A	HOH848
A	HOH849
A	HOH881

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"15163408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"15163408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15163408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---