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1RNN

RIBONUCLEASE A COMPLEX WITH CYTIDYLIC ACID (5'CMP) CRYSTALLIZED FROM 8M SODIUM FORMATE

Functional Information from GO Data
ChainGOidnamespacecontents
E0003676molecular_functionnucleic acid binding
E0004519molecular_functionendonuclease activity
E0004522molecular_functionribonuclease A activity
E0004540molecular_functionRNA nuclease activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0016829molecular_functionlyase activity
E0050830biological_processdefense response to Gram-positive bacterium
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE C5P E 200
ChainResidue
EHIS12
EHOH262
ELYS41
EVAL43
EASN44
ETHR45
EHIS119
EPHE120
EFMT131
EHOH255

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FMT E 131
ChainResidue
EGLN11
EHIS12
EHIS119
EPHE120
EC5P200

Functional Information from PROSITE/UniProt
site_idPS00127
Number of Residues7
DetailsRNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF
ChainResidueDetails
ECYS40-PHE46

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
EHIS12

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton donor
ChainResidueDetails
EHIS119

site_idSWS_FT_FI3
Number of Residues5
DetailsBINDING:
ChainResidueDetails
ELYS7
EARG10
ELYS41
ELYS66
EARG85

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761
ChainResidueDetails
ELYS1
ELYS7
ELYS37
ELYS41

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:19358553
ChainResidueDetails
EASN34

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1rbn
ChainResidueDetails
EPHE120
EHIS119
EHIS12
ELYS41

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1rbn
ChainResidueDetails
EHIS119
EHIS12
ELYS41

site_idMCSA1
Number of Residues5
DetailsM-CSA 164
ChainResidueDetails
EHIS12hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
ELYS41electrostatic stabiliser, hydrogen bond donor
EHIS119hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
EPHE120electrostatic stabiliser, hydrogen bond donor
EASP121electrostatic stabiliser, hydrogen bond acceptor

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PDB entries from 2024-11-06

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