1RNM

RIBONUCLEASE A COMPLEX WITH CYTIDYLIC ACID (5'CMP) CRYSTALLIZED FROM 80% AMMONIUM SULPHATE

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0003676	molecular_function	nucleic acid binding
E	0004519	molecular_function	endonuclease activity
E	0004522	molecular_function	ribonuclease A activity
E	0004540	molecular_function	RNA nuclease activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0016829	molecular_function	lyase activity
E	0050830	biological_process	defense response to Gram-positive bacterium

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E 125

Chain	Residue
E	GLN11
E	HIS12
E	LYS41
E	VAL118
E	HIS119
E	PHE120
E	C5P200
E	HOH219
E	HOH272

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 126

Chain	Residue
E	SER23
E	HOH217
E	HOH246
E	HOH260

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 E 127

Chain	Residue
E	LYS66
E	LYS66
E	ALA122
E	ALA122
E	SER123
E	SER123
E	C5P200
E	C5P200
E	HOH253
E	HOH253

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE C5P E 200

Chain	Residue
E	HIS12
E	LYS41
E	VAL43
E	ASN44
E	THR45
E	LYS66
E	PHE120
E	SO4125
E	SO4127
E	SO4127
E	HOH247

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Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF

Chain	Residue	Details
E	CYS40-PHE46

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
E	HIS12

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor

Chain	Residue	Details
E	HIS119

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site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
E	LYS7
E	ARG10
E	LYS41
E	LYS66
E	ARG85

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761

Chain	Residue	Details
E	LYS1
E	LYS7
E	LYS37
E	LYS41

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:19358553

Chain	Residue	Details
E	ASN34

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
E	PHE120
E	HIS119
E	HIS12
E	LYS41

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
E	HIS119
E	HIS12
E	LYS41

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 164

Chain	Residue	Details
E	HIS12	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
E	LYS41	electrostatic stabiliser, hydrogen bond donor
E	HIS119	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
E	PHE120	electrostatic stabiliser, hydrogen bond donor
E	ASP121	electrostatic stabiliser, hydrogen bond acceptor

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