Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
site_id | CAT |
Number of Residues | 2 |
Details | CATALYTIC ASPARTIC ACID RESIDUES |
Chain | Residue |
A | ASP32 |
A | ASP215 |
site_id | S1 |
Number of Residues | 9 |
Details | SUBSTRATE BINDING SUBSITE 1 |
Chain | Residue |
A | VAL30 |
A | ASP32 |
A | TYR75 |
A | THR77 |
A | PHE112 |
A | PHE117 |
A | VAL120 |
A | ASP215 |
A | GLY217 |
site_id | S1' |
Number of Residues | 7 |
Details | SUBSTRATE BINDING SUBSITE 1' |
Chain | Residue |
A | SER76 |
A | LEU213 |
A | ASP215 |
A | ILE291 |
A | PRO292 |
A | THR295 |
A | ALA300 |
site_id | S2 |
Number of Residues | 8 |
Details | SUBSTRATE BINDING SUBSITE 2 |
Chain | Residue |
A | SER76 |
A | THR77 |
A | ALA218 |
A | SER222 |
A | HIS287 |
A | MET289 |
A | ILE291 |
A | ALA300 |
site_id | S2' |
Number of Residues | 7 |
Details | SUBSTRATE BINDING SUBSITE 2' |
Chain | Residue |
A | GLY34 |
A | SER35 |
A | LEU73 |
A | ARG74 |
A | TYR75 |
A | GLN128 |
A | ILE130 |
site_id | S3 |
Number of Residues | 9 |
Details | SUBSTRATE BINDING SUBSITE 3 |
Chain | Residue |
A | THR77 |
A | PRO111 |
A | PHE112 |
A | LEU114 |
A | ALA115 |
A | PHE117 |
A | SER219 |
A | THR12 |
A | GLN13 |
site_id | S4 |
Number of Residues | 5 |
Details | SUBSTRATE BINDING SUBSITE 4 |
Chain | Residue |
A | THR12 |
A | SER219 |
A | TYR220 |
A | PHE242 |
A | HIS287 |
Functional Information from PROSITE/UniProt
site_id | PS00141 |
Number of Residues | 12 |
Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV |
Chain | Residue | Details |
A | VAL29-VAL40 | |
A | ALA212-GLY223 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP32 | |
A | ASP215 | |
Chain | Residue | Details |
A | ASN-1 | |
A | ASN67 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | a catalytic site defined by CSA, PubMed 1807356, 11714911 |
Chain | Residue | Details |
A | ASP215 | |
A | SER35 | |
A | ASP32 | |