Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | CAT |
| Number of Residues | 2 |
| Details | CATALYTIC ASPARTIC ACID RESIDUES |
| Chain | Residue |
| A | ASP32 |
| A | ASP215 |
| site_id | S1 |
| Number of Residues | 9 |
| Details | SUBSTRATE BINDING SUBSITE 1 |
| Chain | Residue |
| A | VAL30 |
| A | ASP32 |
| A | TYR75 |
| A | THR77 |
| A | PHE112 |
| A | PHE117 |
| A | VAL120 |
| A | ASP215 |
| A | GLY217 |
| site_id | S1' |
| Number of Residues | 7 |
| Details | SUBSTRATE BINDING SUBSITE 1' |
| Chain | Residue |
| A | SER76 |
| A | LEU213 |
| A | ASP215 |
| A | ILE291 |
| A | PRO292 |
| A | THR295 |
| A | ALA300 |
| site_id | S2 |
| Number of Residues | 8 |
| Details | SUBSTRATE BINDING SUBSITE 2 |
| Chain | Residue |
| A | SER76 |
| A | THR77 |
| A | ALA218 |
| A | SER222 |
| A | HIS287 |
| A | MET289 |
| A | ILE291 |
| A | ALA300 |
| site_id | S2' |
| Number of Residues | 7 |
| Details | SUBSTRATE BINDING SUBSITE 2' |
| Chain | Residue |
| A | GLY34 |
| A | SER35 |
| A | LEU73 |
| A | ARG74 |
| A | TYR75 |
| A | GLN128 |
| A | ILE130 |
| site_id | S3 |
| Number of Residues | 9 |
| Details | SUBSTRATE BINDING SUBSITE 3 |
| Chain | Residue |
| A | THR77 |
| A | PRO111 |
| A | PHE112 |
| A | LEU114 |
| A | ALA115 |
| A | PHE117 |
| A | SER219 |
| A | THR12 |
| A | GLN13 |
| site_id | S4 |
| Number of Residues | 5 |
| Details | SUBSTRATE BINDING SUBSITE 4 |
| Chain | Residue |
| A | THR12 |
| A | SER219 |
| A | TYR220 |
| A | PHE242 |
| A | HIS287 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV |
| Chain | Residue | Details |
| A | VAL29-VAL40 | |
| A | ALA212-GLY223 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"20927107","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"2493678","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | a catalytic site defined by CSA, PubMed 1807356, 11714911 |
| Chain | Residue | Details |
| A | ASP215 | |
| A | SER35 | |
| A | ASP32 | |
