1RI4

Structure and mechanism of mRNA cap (guanine N-7) methyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0005634	cellular_component	nucleus
A	0006370	biological_process	7-methylguanosine mRNA capping
A	0006397	biological_process	mRNA processing
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
A	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE SAM A 299

Chain	Residue
A	LYS54
A	TYR124
A	GLN140
A	PHE141
A	SER142
A	TYR145
A	HOH304
A	HOH321
A	HOH345
A	HOH353
A	HOH363
A	GLY72
A	CYS73
A	GLY74
A	ASP94
A	ILE95
A	ALA96
A	ASP122
A	SER123

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	251
Details	Domain: {"description":"mRNA cap 0 methyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O43148","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	6
Details	Site: {"description":"mRNA cap binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1qam

Chain	Residue	Details
A	GLN140
A	GLY72
A	ASP94

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