1RH2

RECOMBINANT HUMAN INTERFERON-ALPHA 2B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002286	biological_process	T cell activation involved in immune response
A	0002323	biological_process	natural killer cell activation involved in immune response
A	0005125	molecular_function	cytokine activity
A	0005126	molecular_function	cytokine receptor binding
A	0005132	molecular_function	type I interferon receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006915	biological_process	apoptotic process
A	0006952	biological_process	defense response
A	0006954	biological_process	inflammatory response
A	0006959	biological_process	humoral immune response
A	0007166	biological_process	cell surface receptor signaling pathway
A	0007267	biological_process	cell-cell signaling
A	0010629	biological_process	negative regulation of gene expression
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0030183	biological_process	B cell differentiation
A	0032696	biological_process	negative regulation of interleukin-13 production
A	0032714	biological_process	negative regulation of interleukin-5 production
A	0033141	biological_process	positive regulation of peptidyl-serine phosphorylation of STAT protein
A	0042100	biological_process	B cell proliferation
A	0043330	biological_process	response to exogenous dsRNA
A	0045581	biological_process	negative regulation of T cell differentiation
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046597	biological_process	negative regulation of viral entry into host cell
A	0051607	biological_process	defense response to virus
A	0060337	biological_process	type I interferon-mediated signaling pathway
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0097696	biological_process	cell surface receptor signaling pathway via STAT
A	0098586	biological_process	cellular response to virus
A	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
B	0002250	biological_process	adaptive immune response
B	0002286	biological_process	T cell activation involved in immune response
B	0002323	biological_process	natural killer cell activation involved in immune response
B	0005125	molecular_function	cytokine activity
B	0005126	molecular_function	cytokine receptor binding
B	0005132	molecular_function	type I interferon receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006915	biological_process	apoptotic process
B	0006952	biological_process	defense response
B	0006954	biological_process	inflammatory response
B	0006959	biological_process	humoral immune response
B	0007166	biological_process	cell surface receptor signaling pathway
B	0007267	biological_process	cell-cell signaling
B	0010629	biological_process	negative regulation of gene expression
B	0019221	biological_process	cytokine-mediated signaling pathway
B	0030183	biological_process	B cell differentiation
B	0032696	biological_process	negative regulation of interleukin-13 production
B	0032714	biological_process	negative regulation of interleukin-5 production
B	0033141	biological_process	positive regulation of peptidyl-serine phosphorylation of STAT protein
B	0042100	biological_process	B cell proliferation
B	0043330	biological_process	response to exogenous dsRNA
B	0045581	biological_process	negative regulation of T cell differentiation
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046597	biological_process	negative regulation of viral entry into host cell
B	0051607	biological_process	defense response to virus
B	0060337	biological_process	type I interferon-mediated signaling pathway
B	0062023	cellular_component	collagen-containing extracellular matrix
B	0097696	biological_process	cell surface receptor signaling pathway via STAT
B	0098586	biological_process	cellular response to virus
B	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
C	0002250	biological_process	adaptive immune response
C	0002286	biological_process	T cell activation involved in immune response
C	0002323	biological_process	natural killer cell activation involved in immune response
C	0005125	molecular_function	cytokine activity
C	0005126	molecular_function	cytokine receptor binding
C	0005132	molecular_function	type I interferon receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006915	biological_process	apoptotic process
C	0006952	biological_process	defense response
C	0006954	biological_process	inflammatory response
C	0006959	biological_process	humoral immune response
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007267	biological_process	cell-cell signaling
C	0010629	biological_process	negative regulation of gene expression
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0030183	biological_process	B cell differentiation
C	0032696	biological_process	negative regulation of interleukin-13 production
C	0032714	biological_process	negative regulation of interleukin-5 production
C	0033141	biological_process	positive regulation of peptidyl-serine phosphorylation of STAT protein
C	0042100	biological_process	B cell proliferation
C	0043330	biological_process	response to exogenous dsRNA
C	0045581	biological_process	negative regulation of T cell differentiation
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0046597	biological_process	negative regulation of viral entry into host cell
C	0051607	biological_process	defense response to virus
C	0060337	biological_process	type I interferon-mediated signaling pathway
C	0062023	cellular_component	collagen-containing extracellular matrix
C	0097696	biological_process	cell surface receptor signaling pathway via STAT
C	0098586	biological_process	cellular response to virus
C	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
D	0002250	biological_process	adaptive immune response
D	0002286	biological_process	T cell activation involved in immune response
D	0002323	biological_process	natural killer cell activation involved in immune response
D	0005125	molecular_function	cytokine activity
D	0005126	molecular_function	cytokine receptor binding
D	0005132	molecular_function	type I interferon receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006915	biological_process	apoptotic process
D	0006952	biological_process	defense response
D	0006954	biological_process	inflammatory response
D	0006959	biological_process	humoral immune response
D	0007166	biological_process	cell surface receptor signaling pathway
D	0007267	biological_process	cell-cell signaling
D	0010629	biological_process	negative regulation of gene expression
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0030183	biological_process	B cell differentiation
D	0032696	biological_process	negative regulation of interleukin-13 production
D	0032714	biological_process	negative regulation of interleukin-5 production
D	0033141	biological_process	positive regulation of peptidyl-serine phosphorylation of STAT protein
D	0042100	biological_process	B cell proliferation
D	0043330	biological_process	response to exogenous dsRNA
D	0045581	biological_process	negative regulation of T cell differentiation
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0046597	biological_process	negative regulation of viral entry into host cell
D	0051607	biological_process	defense response to virus
D	0060337	biological_process	type I interferon-mediated signaling pathway
D	0062023	cellular_component	collagen-containing extracellular matrix
D	0097696	biological_process	cell surface receptor signaling pathway via STAT
D	0098586	biological_process	cellular response to virus
D	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
E	0002250	biological_process	adaptive immune response
E	0002286	biological_process	T cell activation involved in immune response
E	0002323	biological_process	natural killer cell activation involved in immune response
E	0005125	molecular_function	cytokine activity
E	0005126	molecular_function	cytokine receptor binding
E	0005132	molecular_function	type I interferon receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006915	biological_process	apoptotic process
E	0006952	biological_process	defense response
E	0006954	biological_process	inflammatory response
E	0006959	biological_process	humoral immune response
E	0007166	biological_process	cell surface receptor signaling pathway
E	0007267	biological_process	cell-cell signaling
E	0010629	biological_process	negative regulation of gene expression
E	0019221	biological_process	cytokine-mediated signaling pathway
E	0030183	biological_process	B cell differentiation
E	0032696	biological_process	negative regulation of interleukin-13 production
E	0032714	biological_process	negative regulation of interleukin-5 production
E	0033141	biological_process	positive regulation of peptidyl-serine phosphorylation of STAT protein
E	0042100	biological_process	B cell proliferation
E	0043330	biological_process	response to exogenous dsRNA
E	0045581	biological_process	negative regulation of T cell differentiation
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0046597	biological_process	negative regulation of viral entry into host cell
E	0051607	biological_process	defense response to virus
E	0060337	biological_process	type I interferon-mediated signaling pathway
E	0062023	cellular_component	collagen-containing extracellular matrix
E	0097696	biological_process	cell surface receptor signaling pathway via STAT
E	0098586	biological_process	cellular response to virus
E	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
F	0002250	biological_process	adaptive immune response
F	0002286	biological_process	T cell activation involved in immune response
F	0002323	biological_process	natural killer cell activation involved in immune response
F	0005125	molecular_function	cytokine activity
F	0005126	molecular_function	cytokine receptor binding
F	0005132	molecular_function	type I interferon receptor binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006915	biological_process	apoptotic process
F	0006952	biological_process	defense response
F	0006954	biological_process	inflammatory response
F	0006959	biological_process	humoral immune response
F	0007166	biological_process	cell surface receptor signaling pathway
F	0007267	biological_process	cell-cell signaling
F	0010629	biological_process	negative regulation of gene expression
F	0019221	biological_process	cytokine-mediated signaling pathway
F	0030183	biological_process	B cell differentiation
F	0032696	biological_process	negative regulation of interleukin-13 production
F	0032714	biological_process	negative regulation of interleukin-5 production
F	0033141	biological_process	positive regulation of peptidyl-serine phosphorylation of STAT protein
F	0042100	biological_process	B cell proliferation
F	0043330	biological_process	response to exogenous dsRNA
F	0045581	biological_process	negative regulation of T cell differentiation
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0046597	biological_process	negative regulation of viral entry into host cell
F	0051607	biological_process	defense response to virus
F	0060337	biological_process	type I interferon-mediated signaling pathway
F	0062023	cellular_component	collagen-containing extracellular matrix
F	0097696	biological_process	cell surface receptor signaling pathway via STAT
F	0098586	biological_process	cellular response to virus
F	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production

Functional Information from PROSITE/UniProt

site_id	PS00252
Number of Residues	19
Details	INTERFERON_A_B_D Interferon alpha, beta and delta family signature. YFqRItlYLkekkyspCAW

Chain	Residue	Details
A	TYR122-TRP140

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:2049076

Chain	Residue	Details
A	THR106
B	THR106
C	THR106
D	THR106
E	THR106
F	THR106

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