1RAM

A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005737	cellular_component	cytoplasm
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005737	cellular_component	cytoplasm
B	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DTT A 1

Chain	Residue
A	ASP80
A	ASP151

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DTT B 2

Chain	Residue
B	ASP80
B	ASP151
B	ASP153

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Functional Information from PROSITE/UniProt

site_id	PS01204
Number of Residues	7
Details	REL_1 NF-kappa-B/Rel/dorsal domain signature. FRYkCEG

Chain	Residue	Details
A	PHE34-GLY40

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: S-nitrosocysteine; alternate => ECO:0000269|PubMed:22244329

Chain	Residue	Details
A	CYS38
B	CYS38

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; by PCAF and EP300; alternate => ECO:0000250|UniProtKB:Q04206

Chain	Residue	Details
A	LYS122
A	LYS123
B	LYS122
B	LYS123

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	THR176
B	THR176

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q04206

Chain	Residue	Details
A	LYS218
A	LYS221
B	LYS218
B	LYS221

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q04206

Chain	Residue	Details
A	THR254
B	THR254

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine; by RPS6KA4 and RPS6KA5 => ECO:0000250|UniProtKB:Q04206

Chain	Residue	Details
A	SER276
B	SER276

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site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q04206

Chain	Residue	Details
A	SER281
B	SER281

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site_id	SWS_FT_FI8
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3) => ECO:0000250

Chain	Residue	Details
A	LYS37
B	LYS37

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site_id	SWS_FT_FI9
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3); alternate => ECO:0000250

Chain	Residue	Details
A	LYS122
A	LYS123
B	LYS122
B	LYS123

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