Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1R8Y

Crystal Structure of Mouse Glycine N-Methyltransferase (Monoclinic Form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005542	molecular_function	folic acid binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005977	biological_process	glycogen metabolic process
A	0006111	biological_process	regulation of gluconeogenesis
A	0006544	biological_process	glycine metabolic process
A	0006546	biological_process	glycine catabolic process
A	0006555	biological_process	methionine metabolic process
A	0006730	biological_process	one-carbon metabolic process
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
A	0016594	molecular_function	glycine binding
A	0017174	molecular_function	glycine N-methyltransferase activity
A	0018013	biological_process	N-terminal peptidyl-glycine methylation
A	0034708	cellular_component	methyltransferase complex
A	0042802	molecular_function	identical protein binding
A	0046500	biological_process	S-adenosylmethionine metabolic process
A	0050843	biological_process	S-adenosylmethionine catabolic process
A	0051289	biological_process	protein homotetramerization
A	1901052	biological_process	sarcosine metabolic process
A	1901054	biological_process	sarcosine biosynthetic process
A	1901605	biological_process	alpha-amino acid metabolic process
A	1904047	molecular_function	S-adenosyl-L-methionine binding
B	0005542	molecular_function	folic acid binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005977	biological_process	glycogen metabolic process
B	0006111	biological_process	regulation of gluconeogenesis
B	0006544	biological_process	glycine metabolic process
B	0006546	biological_process	glycine catabolic process
B	0006555	biological_process	methionine metabolic process
B	0006730	biological_process	one-carbon metabolic process
B	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
B	0016594	molecular_function	glycine binding
B	0017174	molecular_function	glycine N-methyltransferase activity
B	0018013	biological_process	N-terminal peptidyl-glycine methylation
B	0034708	cellular_component	methyltransferase complex
B	0042802	molecular_function	identical protein binding
B	0046500	biological_process	S-adenosylmethionine metabolic process
B	0050843	biological_process	S-adenosylmethionine catabolic process
B	0051289	biological_process	protein homotetramerization
B	1901052	biological_process	sarcosine metabolic process
B	1901054	biological_process	sarcosine biosynthetic process
B	1901605	biological_process	alpha-amino acid metabolic process
B	1904047	molecular_function	S-adenosyl-L-methionine binding
C	0005542	molecular_function	folic acid binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005977	biological_process	glycogen metabolic process
C	0006111	biological_process	regulation of gluconeogenesis
C	0006544	biological_process	glycine metabolic process
C	0006546	biological_process	glycine catabolic process
C	0006555	biological_process	methionine metabolic process
C	0006730	biological_process	one-carbon metabolic process
C	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
C	0016594	molecular_function	glycine binding
C	0017174	molecular_function	glycine N-methyltransferase activity
C	0018013	biological_process	N-terminal peptidyl-glycine methylation
C	0034708	cellular_component	methyltransferase complex
C	0042802	molecular_function	identical protein binding
C	0046500	biological_process	S-adenosylmethionine metabolic process
C	0050843	biological_process	S-adenosylmethionine catabolic process
C	0051289	biological_process	protein homotetramerization
C	1901052	biological_process	sarcosine metabolic process
C	1901054	biological_process	sarcosine biosynthetic process
C	1901605	biological_process	alpha-amino acid metabolic process
C	1904047	molecular_function	S-adenosyl-L-methionine binding
D	0005542	molecular_function	folic acid binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005977	biological_process	glycogen metabolic process
D	0006111	biological_process	regulation of gluconeogenesis
D	0006544	biological_process	glycine metabolic process
D	0006546	biological_process	glycine catabolic process
D	0006555	biological_process	methionine metabolic process
D	0006730	biological_process	one-carbon metabolic process
D	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
D	0016594	molecular_function	glycine binding
D	0017174	molecular_function	glycine N-methyltransferase activity
D	0018013	biological_process	N-terminal peptidyl-glycine methylation
D	0034708	cellular_component	methyltransferase complex
D	0042802	molecular_function	identical protein binding
D	0046500	biological_process	S-adenosylmethionine metabolic process
D	0050843	biological_process	S-adenosylmethionine catabolic process
D	0051289	biological_process	protein homotetramerization
D	1901052	biological_process	sarcosine metabolic process
D	1901054	biological_process	sarcosine biosynthetic process
D	1901605	biological_process	alpha-amino acid metabolic process
D	1904047	molecular_function	S-adenosyl-L-methionine binding
E	0005542	molecular_function	folic acid binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005977	biological_process	glycogen metabolic process
E	0006111	biological_process	regulation of gluconeogenesis
E	0006544	biological_process	glycine metabolic process
E	0006546	biological_process	glycine catabolic process
E	0006555	biological_process	methionine metabolic process
E	0006730	biological_process	one-carbon metabolic process
E	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
E	0016594	molecular_function	glycine binding
E	0017174	molecular_function	glycine N-methyltransferase activity
E	0018013	biological_process	N-terminal peptidyl-glycine methylation
E	0034708	cellular_component	methyltransferase complex
E	0042802	molecular_function	identical protein binding
E	0046500	biological_process	S-adenosylmethionine metabolic process
E	0050843	biological_process	S-adenosylmethionine catabolic process
E	0051289	biological_process	protein homotetramerization
E	1901052	biological_process	sarcosine metabolic process
E	1901054	biological_process	sarcosine biosynthetic process
E	1901605	biological_process	alpha-amino acid metabolic process
E	1904047	molecular_function	S-adenosyl-L-methionine binding
F	0005542	molecular_function	folic acid binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005977	biological_process	glycogen metabolic process
F	0006111	biological_process	regulation of gluconeogenesis
F	0006544	biological_process	glycine metabolic process
F	0006546	biological_process	glycine catabolic process
F	0006555	biological_process	methionine metabolic process
F	0006730	biological_process	one-carbon metabolic process
F	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
F	0016594	molecular_function	glycine binding
F	0017174	molecular_function	glycine N-methyltransferase activity
F	0018013	biological_process	N-terminal peptidyl-glycine methylation
F	0034708	cellular_component	methyltransferase complex
F	0042802	molecular_function	identical protein binding
F	0046500	biological_process	S-adenosylmethionine metabolic process
F	0050843	biological_process	S-adenosylmethionine catabolic process
F	0051289	biological_process	protein homotetramerization
F	1901052	biological_process	sarcosine metabolic process
F	1901054	biological_process	sarcosine biosynthetic process
F	1901605	biological_process	alpha-amino acid metabolic process
F	1904047	molecular_function	S-adenosyl-L-methionine binding
G	0005542	molecular_function	folic acid binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005977	biological_process	glycogen metabolic process
G	0006111	biological_process	regulation of gluconeogenesis
G	0006544	biological_process	glycine metabolic process
G	0006546	biological_process	glycine catabolic process
G	0006555	biological_process	methionine metabolic process
G	0006730	biological_process	one-carbon metabolic process
G	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
G	0016594	molecular_function	glycine binding
G	0017174	molecular_function	glycine N-methyltransferase activity
G	0018013	biological_process	N-terminal peptidyl-glycine methylation
G	0034708	cellular_component	methyltransferase complex
G	0042802	molecular_function	identical protein binding
G	0046500	biological_process	S-adenosylmethionine metabolic process
G	0050843	biological_process	S-adenosylmethionine catabolic process
G	0051289	biological_process	protein homotetramerization
G	1901052	biological_process	sarcosine metabolic process
G	1901054	biological_process	sarcosine biosynthetic process
G	1901605	biological_process	alpha-amino acid metabolic process
G	1904047	molecular_function	S-adenosyl-L-methionine binding
H	0005542	molecular_function	folic acid binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005977	biological_process	glycogen metabolic process
H	0006111	biological_process	regulation of gluconeogenesis
H	0006544	biological_process	glycine metabolic process
H	0006546	biological_process	glycine catabolic process
H	0006555	biological_process	methionine metabolic process
H	0006730	biological_process	one-carbon metabolic process
H	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
H	0016594	molecular_function	glycine binding
H	0017174	molecular_function	glycine N-methyltransferase activity
H	0018013	biological_process	N-terminal peptidyl-glycine methylation
H	0034708	cellular_component	methyltransferase complex
H	0042802	molecular_function	identical protein binding
H	0046500	biological_process	S-adenosylmethionine metabolic process
H	0050843	biological_process	S-adenosylmethionine catabolic process
H	0051289	biological_process	protein homotetramerization
H	1901052	biological_process	sarcosine metabolic process
H	1901054	biological_process	sarcosine biosynthetic process
H	1901605	biological_process	alpha-amino acid metabolic process
H	1904047	molecular_function	S-adenosyl-L-methionine binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 1262

Chain	Residue
A	ARG255
A	GLY260
A	CYS262

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 1282

Chain	Residue
A	ARG175
A	ASN176
A	CYS282

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BME B 2057

Chain	Residue
B	ARG165
B	GLY167
E	LYS190
B	HIS55
B	CYS57
B	ASP131

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME D 4185

Chain	Residue
A	ASN210
D	CYS185
D	ILE202
D	THR204

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME D 4246

Chain	Residue
D	ALA213
D	CYS246

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME D 4262

Chain	Residue
D	CYS262
D	GLN263
D	HIS264

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME E 5246

Chain	Residue
E	ALA213
E	CYS246

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME F 6282

Chain	Residue
F	TYR179
F	CYS282

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME G 7246

Chain	Residue
G	ALA213
G	CYS246

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME G 7282

Chain	Residue
G	ASN176
G	TYR179
G	PRO281
G	CYS282

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13255","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"N-acetylvaline","evidences":[{"source":"UniProtKB","id":"P13255","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17242355","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	32
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
A	GLU15

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
B	GLU15

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
C	GLU15

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
D	GLU15

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
E	GLU15

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
F	GLU15

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
G	GLU15

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
H	GLU15

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)