Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1R8Y

Crystal Structure of Mouse Glycine N-Methyltransferase (Monoclinic Form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005542	molecular_function	folic acid binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005977	biological_process	glycogen metabolic process
A	0006111	biological_process	regulation of gluconeogenesis
A	0006544	biological_process	glycine metabolic process
A	0006555	biological_process	methionine metabolic process
A	0006730	biological_process	one-carbon metabolic process
A	0008168	molecular_function	methyltransferase activity
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
A	0016594	molecular_function	glycine binding
A	0017174	molecular_function	glycine N-methyltransferase activity
A	0032259	biological_process	methylation
A	0034708	cellular_component	methyltransferase complex
A	0042802	molecular_function	identical protein binding
A	0046498	biological_process	S-adenosylhomocysteine metabolic process
A	0046500	biological_process	S-adenosylmethionine metabolic process
A	0051289	biological_process	protein homotetramerization
A	1901052	biological_process	sarcosine metabolic process
A	1904047	molecular_function	S-adenosyl-L-methionine binding
B	0005542	molecular_function	folic acid binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005977	biological_process	glycogen metabolic process
B	0006111	biological_process	regulation of gluconeogenesis
B	0006544	biological_process	glycine metabolic process
B	0006555	biological_process	methionine metabolic process
B	0006730	biological_process	one-carbon metabolic process
B	0008168	molecular_function	methyltransferase activity
B	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
B	0016594	molecular_function	glycine binding
B	0017174	molecular_function	glycine N-methyltransferase activity
B	0032259	biological_process	methylation
B	0034708	cellular_component	methyltransferase complex
B	0042802	molecular_function	identical protein binding
B	0046498	biological_process	S-adenosylhomocysteine metabolic process
B	0046500	biological_process	S-adenosylmethionine metabolic process
B	0051289	biological_process	protein homotetramerization
B	1901052	biological_process	sarcosine metabolic process
B	1904047	molecular_function	S-adenosyl-L-methionine binding
C	0005542	molecular_function	folic acid binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005977	biological_process	glycogen metabolic process
C	0006111	biological_process	regulation of gluconeogenesis
C	0006544	biological_process	glycine metabolic process
C	0006555	biological_process	methionine metabolic process
C	0006730	biological_process	one-carbon metabolic process
C	0008168	molecular_function	methyltransferase activity
C	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
C	0016594	molecular_function	glycine binding
C	0017174	molecular_function	glycine N-methyltransferase activity
C	0032259	biological_process	methylation
C	0034708	cellular_component	methyltransferase complex
C	0042802	molecular_function	identical protein binding
C	0046498	biological_process	S-adenosylhomocysteine metabolic process
C	0046500	biological_process	S-adenosylmethionine metabolic process
C	0051289	biological_process	protein homotetramerization
C	1901052	biological_process	sarcosine metabolic process
C	1904047	molecular_function	S-adenosyl-L-methionine binding
D	0005542	molecular_function	folic acid binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005977	biological_process	glycogen metabolic process
D	0006111	biological_process	regulation of gluconeogenesis
D	0006544	biological_process	glycine metabolic process
D	0006555	biological_process	methionine metabolic process
D	0006730	biological_process	one-carbon metabolic process
D	0008168	molecular_function	methyltransferase activity
D	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
D	0016594	molecular_function	glycine binding
D	0017174	molecular_function	glycine N-methyltransferase activity
D	0032259	biological_process	methylation
D	0034708	cellular_component	methyltransferase complex
D	0042802	molecular_function	identical protein binding
D	0046498	biological_process	S-adenosylhomocysteine metabolic process
D	0046500	biological_process	S-adenosylmethionine metabolic process
D	0051289	biological_process	protein homotetramerization
D	1901052	biological_process	sarcosine metabolic process
D	1904047	molecular_function	S-adenosyl-L-methionine binding
E	0005542	molecular_function	folic acid binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005977	biological_process	glycogen metabolic process
E	0006111	biological_process	regulation of gluconeogenesis
E	0006544	biological_process	glycine metabolic process
E	0006555	biological_process	methionine metabolic process
E	0006730	biological_process	one-carbon metabolic process
E	0008168	molecular_function	methyltransferase activity
E	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
E	0016594	molecular_function	glycine binding
E	0017174	molecular_function	glycine N-methyltransferase activity
E	0032259	biological_process	methylation
E	0034708	cellular_component	methyltransferase complex
E	0042802	molecular_function	identical protein binding
E	0046498	biological_process	S-adenosylhomocysteine metabolic process
E	0046500	biological_process	S-adenosylmethionine metabolic process
E	0051289	biological_process	protein homotetramerization
E	1901052	biological_process	sarcosine metabolic process
E	1904047	molecular_function	S-adenosyl-L-methionine binding
F	0005542	molecular_function	folic acid binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005977	biological_process	glycogen metabolic process
F	0006111	biological_process	regulation of gluconeogenesis
F	0006544	biological_process	glycine metabolic process
F	0006555	biological_process	methionine metabolic process
F	0006730	biological_process	one-carbon metabolic process
F	0008168	molecular_function	methyltransferase activity
F	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
F	0016594	molecular_function	glycine binding
F	0017174	molecular_function	glycine N-methyltransferase activity
F	0032259	biological_process	methylation
F	0034708	cellular_component	methyltransferase complex
F	0042802	molecular_function	identical protein binding
F	0046498	biological_process	S-adenosylhomocysteine metabolic process
F	0046500	biological_process	S-adenosylmethionine metabolic process
F	0051289	biological_process	protein homotetramerization
F	1901052	biological_process	sarcosine metabolic process
F	1904047	molecular_function	S-adenosyl-L-methionine binding
G	0005542	molecular_function	folic acid binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005977	biological_process	glycogen metabolic process
G	0006111	biological_process	regulation of gluconeogenesis
G	0006544	biological_process	glycine metabolic process
G	0006555	biological_process	methionine metabolic process
G	0006730	biological_process	one-carbon metabolic process
G	0008168	molecular_function	methyltransferase activity
G	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
G	0016594	molecular_function	glycine binding
G	0017174	molecular_function	glycine N-methyltransferase activity
G	0032259	biological_process	methylation
G	0034708	cellular_component	methyltransferase complex
G	0042802	molecular_function	identical protein binding
G	0046498	biological_process	S-adenosylhomocysteine metabolic process
G	0046500	biological_process	S-adenosylmethionine metabolic process
G	0051289	biological_process	protein homotetramerization
G	1901052	biological_process	sarcosine metabolic process
G	1904047	molecular_function	S-adenosyl-L-methionine binding
H	0005542	molecular_function	folic acid binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005977	biological_process	glycogen metabolic process
H	0006111	biological_process	regulation of gluconeogenesis
H	0006544	biological_process	glycine metabolic process
H	0006555	biological_process	methionine metabolic process
H	0006730	biological_process	one-carbon metabolic process
H	0008168	molecular_function	methyltransferase activity
H	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
H	0016594	molecular_function	glycine binding
H	0017174	molecular_function	glycine N-methyltransferase activity
H	0032259	biological_process	methylation
H	0034708	cellular_component	methyltransferase complex
H	0042802	molecular_function	identical protein binding
H	0046498	biological_process	S-adenosylhomocysteine metabolic process
H	0046500	biological_process	S-adenosylmethionine metabolic process
H	0051289	biological_process	protein homotetramerization
H	1901052	biological_process	sarcosine metabolic process
H	1904047	molecular_function	S-adenosyl-L-methionine binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 1262

Chain	Residue
A	ARG255
A	GLY260
A	CYS262

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 1282

Chain	Residue
A	ARG175
A	ASN176
A	CYS282

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BME B 2057

Chain	Residue
B	ARG165
B	GLY167
E	LYS190
B	HIS55
B	CYS57
B	ASP131

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME D 4185

Chain	Residue
A	ASN210
D	CYS185
D	ILE202
D	THR204

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME D 4246

Chain	Residue
D	ALA213
D	CYS246

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME D 4262

Chain	Residue
D	CYS262
D	GLN263
D	HIS264

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME E 5246

Chain	Residue
E	ALA213
E	CYS246

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME F 6282

Chain	Residue
F	TYR179
F	CYS282

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME G 7246

Chain	Residue
G	ALA213
G	CYS246

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME G 7282

Chain	Residue
G	ASN176
G	TYR179
G	PRO281
G	CYS282

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	112
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P13255

Chain	Residue	Details
A	SER3
A	LEU136
H	TYR5
H	TYR21
H	TRP30
H	TYR33
H	ARG40
H	ALA64
H	ASP85
H	ASN116
H	LEU136
H	ARG175
A	ARG175
H	HIS214
H	TYR220
H	ARG239
A	HIS214
A	TYR220
A	ARG239
B	SER3
B	TYR5
B	TYR21
B	TRP30
B	TYR33
A	TYR5
B	ARG40
B	ALA64
B	ASP85
B	ASN116
B	LEU136
B	ARG175
B	HIS214
B	TYR220
B	ARG239
C	SER3
A	TYR21
C	TYR5
C	TYR21
C	TRP30
C	TYR33
C	ARG40
C	ALA64
C	ASP85
C	ASN116
C	LEU136
C	ARG175
A	TRP30
C	HIS214
C	TYR220
C	ARG239
D	SER3
D	TYR5
D	TYR21
D	TRP30
D	TYR33
D	ARG40
D	ALA64
A	TYR33
D	ASP85
D	ASN116
D	LEU136
D	ARG175
D	HIS214
D	TYR220
D	ARG239
E	SER3
E	TYR5
E	TYR21
A	ARG40
E	TRP30
E	TYR33
E	ARG40
E	ALA64
E	ASP85
E	ASN116
E	LEU136
E	ARG175
E	HIS214
E	TYR220
A	ALA64
E	ARG239
F	SER3
F	TYR5
F	TYR21
F	TRP30
F	TYR33
F	ARG40
F	ALA64
F	ASP85
F	ASN116
A	ASP85
F	LEU136
F	ARG175
F	HIS214
F	TYR220
F	ARG239
G	SER3
G	TYR5
G	TYR21
G	TRP30
G	TYR33
A	ASN116
G	ARG40
G	ALA64
G	ASP85
G	ASN116
G	LEU136
G	ARG175
G	HIS214
G	TYR220
G	ARG239
H	SER3

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N-acetylvaline => ECO:0000250\|UniProtKB:P13255

Chain	Residue	Details
A	VAL1
B	VAL1
C	VAL1
D	VAL1
E	VAL1
F	VAL1
G	VAL1
H	VAL1

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17242355, ECO:0007744\|PubMed:21183079

Chain	Residue	Details
A	SER9
B	SER9
C	SER9
D	SER9
E	SER9
F	SER9
G	SER9
H	SER9

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:21183079

Chain	Residue	Details
A	TYR33
B	TYR33
C	TYR33
D	TYR33
E	TYR33
F	TYR33
G	TYR33
H	TYR33

site_id	SWS_FT_FI5
Number of Residues	32
Details	MOD_RES: N6-succinyllysine => ECO:0007744\|PubMed:23806337

Chain	Residue	Details
A	LYS45
C	LYS190
C	LYS195
C	LYS200
D	LYS45
D	LYS190
D	LYS195
D	LYS200
E	LYS45
E	LYS190
E	LYS195
A	LYS190
E	LYS200
F	LYS45
F	LYS190
F	LYS195
F	LYS200
G	LYS45
G	LYS190
G	LYS195
G	LYS200
H	LYS45
A	LYS195
H	LYS190
H	LYS195
H	LYS200
A	LYS200
B	LYS45
B	LYS190
B	LYS195
B	LYS200
C	LYS45

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
A	GLU15

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
B	GLU15

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
C	GLU15

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
D	GLU15

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
E	GLU15

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
F	GLU15

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
G	GLU15

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1xva

Chain	Residue	Details
H	GLU15

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)