1R5K
Human Estrogen Receptor alpha Ligand-Binding Domain In Complex With GW5638
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GW5 A 600 |
| Chain | Residue |
| A | THR347 |
| A | ALA350 |
| A | ASP351 |
| A | PHE404 |
| A | MET421 |
| A | GLY521 |
| A | TYR537 |
| A | HOH700 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GW5 B 601 |
| Chain | Residue |
| B | THR347 |
| B | ALA350 |
| B | ASP351 |
| B | PHE404 |
| B | MET421 |
| B | LEU428 |
| B | GLY521 |
| B | LEU525 |
| B | LEU536 |
| B | TYR537 |
| B | LEU346 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GW5 C 602 |
| Chain | Residue |
| A | GLU330 |
| A | HOH702 |
| C | LEU346 |
| C | THR347 |
| C | ALA350 |
| C | ASP351 |
| C | MET421 |
| C | GLY521 |
| C | LEU525 |
| C | TYR537 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
