1R5K
Human Estrogen Receptor alpha Ligand-Binding Domain In Complex With GW5638
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GW5 A 600 |
| Chain | Residue |
| A | THR347 |
| A | ALA350 |
| A | ASP351 |
| A | PHE404 |
| A | MET421 |
| A | GLY521 |
| A | TYR537 |
| A | HOH700 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GW5 B 601 |
| Chain | Residue |
| B | THR347 |
| B | ALA350 |
| B | ASP351 |
| B | PHE404 |
| B | MET421 |
| B | LEU428 |
| B | GLY521 |
| B | LEU525 |
| B | LEU536 |
| B | TYR537 |
| B | LEU346 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GW5 C 602 |
| Chain | Residue |
| A | GLU330 |
| A | HOH702 |
| C | LEU346 |
| C | THR347 |
| C | ALA350 |
| C | ASP351 |
| C | MET421 |
| C | GLY521 |
| C | LEU525 |
| C | TYR537 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | GLU353 | |
| A | ARG394 | |
| A | HIS524 | |
| B | GLU353 | |
| B | ARG394 | |
| B | HIS524 | |
| C | GLU353 | |
| C | ARG394 | |
| C | HIS524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | TYR537 | |
| B | TYR537 | |
| C | TYR537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 | |
| C | CYS447 |
