Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1R56

UNCOMPLEXED URATE OXIDASE FROM ASPERGILLUS FLAVUS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004846	molecular_function	urate oxidase activity
A	0005777	cellular_component	peroxisome
A	0006144	biological_process	purine nucleobase metabolic process
A	0006145	biological_process	purine nucleobase catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0019628	biological_process	urate catabolic process
B	0004846	molecular_function	urate oxidase activity
B	0005777	cellular_component	peroxisome
B	0006144	biological_process	purine nucleobase metabolic process
B	0006145	biological_process	purine nucleobase catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0019628	biological_process	urate catabolic process
C	0004846	molecular_function	urate oxidase activity
C	0005777	cellular_component	peroxisome
C	0006144	biological_process	purine nucleobase metabolic process
C	0006145	biological_process	purine nucleobase catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0019628	biological_process	urate catabolic process
D	0004846	molecular_function	urate oxidase activity
D	0005777	cellular_component	peroxisome
D	0006144	biological_process	purine nucleobase metabolic process
D	0006145	biological_process	purine nucleobase catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0019628	biological_process	urate catabolic process
E	0004846	molecular_function	urate oxidase activity
E	0005777	cellular_component	peroxisome
E	0006144	biological_process	purine nucleobase metabolic process
E	0006145	biological_process	purine nucleobase catabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0019628	biological_process	urate catabolic process
F	0004846	molecular_function	urate oxidase activity
F	0005777	cellular_component	peroxisome
F	0006144	biological_process	purine nucleobase metabolic process
F	0006145	biological_process	purine nucleobase catabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0019628	biological_process	urate catabolic process
G	0004846	molecular_function	urate oxidase activity
G	0005777	cellular_component	peroxisome
G	0006144	biological_process	purine nucleobase metabolic process
G	0006145	biological_process	purine nucleobase catabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0019628	biological_process	urate catabolic process
H	0004846	molecular_function	urate oxidase activity
H	0005777	cellular_component	peroxisome
H	0006144	biological_process	purine nucleobase metabolic process
H	0006145	biological_process	purine nucleobase catabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0019628	biological_process	urate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PEG A 3126

Chain	Residue
A	SER157
A	GLN158
A	ARG176
A	LEU178
A	SER224
A	ALA225
A	SER226
A	VAL227
A	THR230

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG B 4126

Chain	Residue
B	PHE159
B	ARG176
B	ALA225
B	SER226
B	VAL227
B	GLN228

Functional Information from PROSITE/UniProt

site_id	PS00366
Number of Residues	28
Details	URICASE Uricase signature. LtVLKSTnSqFwgFlrdeYttLketwdR

Chain	Residue	Details
A	LEU149-ARG176

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ACT_SITE: Charge relay system => ECO:0000269\|PubMed:24466188, ECO:0007744\|PDB:4N3M, ECO:0007744\|PDB:4N9M, ECO:0007744\|PDB:4N9S, ECO:0007744\|PDB:4N9V

Chain	Residue	Details
A	ASP11
D	ASP11
D	ASP58
D	TYR257
E	ASP11
E	ASP58
E	TYR257
F	ASP11
F	ASP58
F	TYR257
G	ASP11
A	ASP58
G	ASP58
G	TYR257
H	ASP11
H	ASP58
H	TYR257
A	TYR257
B	ASP11
B	ASP58
B	TYR257
C	ASP11
C	ASP58
C	TYR257

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2FXL, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3LD4, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9S, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	ASP58
B	ASP58
C	ASP58
D	ASP58
E	ASP58
F	ASP58
G	ASP58
H	ASP58

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3LD4, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9S

Chain	Residue	Details
A	SER59
B	SER59
C	SER59
D	SER59
E	SER59
F	SER59
G	SER59
H	SER59

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WS3, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	TRP160
B	TRP160
C	TRP160
D	TRP160
E	TRP160
F	TRP160
G	TRP160
H	TRP160

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:1WS3, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	ILE177
B	ILE177
C	ILE177
D	ILE177
E	ILE177
F	ILE177
G	ILE177
H	ILE177

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	GLN228
B	GLN228
C	GLN228
D	GLN228
E	GLN228
F	GLN228
G	GLN228
H	GLN228

site_id	SWS_FT_FI7
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3LD4, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9S, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	ALA229
B	ALA229
C	ALA229
D	ALA229
E	ALA229
F	ALA229
G	ALA229
H	ALA229

site_id	SWS_FT_FI8
Number of Residues	8
Details	BINDING: BINDING => ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6

Chain	Residue	Details
A	LYS255
B	LYS255
C	LYS255
D	LYS255
E	LYS255
F	LYS255
G	LYS255
H	LYS255

site_id	SWS_FT_FI9
Number of Residues	8
Details	MOD_RES: N-acetylserine => ECO:0000305\|PubMed:1339455, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R4U, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1R56, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:1WS3, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FXL, ECO:0007744\|PDB:3BJP, ECO:0007744\|PDB:4FSK

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2
G	ALA2
H	ALA2

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
A	GLN228
A	ARG176

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
B	GLN228
B	ARG176

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
C	GLN228
C	ARG176

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
D	GLN228
D	ARG176

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
E	GLN228
E	ARG176

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
F	GLN228
F	ARG176

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
G	GLN228
G	ARG176

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
H	GLN228
H	ARG176

site_id	MCSA1
Number of Residues	5
Details	M-CSA 118

Chain	Residue	Details
A	ASP11	hydrogen bond donor, proton acceptor, proton donor, proton relay
A	ASP58	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
A	ILE177	electrostatic stabiliser
A	ALA229	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	TYR257	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_id	MCSA2
Number of Residues	5
Details	M-CSA 118

Chain	Residue	Details
B	ASP11	hydrogen bond donor, proton acceptor, proton donor, proton relay
B	ASP58	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
B	ILE177	electrostatic stabiliser
B	ALA229	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
B	TYR257	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_id	MCSA3
Number of Residues	5
Details	M-CSA 118

Chain	Residue	Details
C	ASP11	hydrogen bond donor, proton acceptor, proton donor, proton relay
C	ASP58	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
C	ILE177	electrostatic stabiliser
C	ALA229	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
C	TYR257	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_id	MCSA4
Number of Residues	5
Details	M-CSA 118

Chain	Residue	Details
D	ASP11	hydrogen bond donor, proton acceptor, proton donor, proton relay
D	ASP58	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
D	ILE177	electrostatic stabiliser
D	ALA229	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
D	TYR257	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_id	MCSA5
Number of Residues	5
Details	M-CSA 118

Chain	Residue	Details
E	ASP11	hydrogen bond donor, proton acceptor, proton donor, proton relay
E	ASP58	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
E	ILE177	electrostatic stabiliser
E	ALA229	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
E	TYR257	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_id	MCSA6
Number of Residues	5
Details	M-CSA 118

Chain	Residue	Details
F	ASP11	hydrogen bond donor, proton acceptor, proton donor, proton relay
F	ASP58	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
F	ILE177	electrostatic stabiliser
F	ALA229	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
F	TYR257	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_id	MCSA7
Number of Residues	5
Details	M-CSA 118

Chain	Residue	Details
G	ASP11	hydrogen bond donor, proton acceptor, proton donor, proton relay
G	ASP58	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
G	ILE177	electrostatic stabiliser
G	ALA229	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
G	TYR257	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_id	MCSA8
Number of Residues	5
Details	M-CSA 118

Chain	Residue	Details
H	ASP11	hydrogen bond donor, proton acceptor, proton donor, proton relay
H	ASP58	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
H	ILE177	electrostatic stabiliser
H	ALA229	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
H	TYR257	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)