1R4P
Shiga toxin type 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017148 | biological_process | negative regulation of translation |
| A | 0030598 | molecular_function | rRNA N-glycosylase activity |
| A | 0090729 | molecular_function | toxin activity |
| A | 0098676 | biological_process | modulation of host virulence by virus |
| B | 0005576 | cellular_component | extracellular region |
| B | 0019836 | biological_process | hemolysis by symbiont of host erythrocytes |
| B | 0090729 | molecular_function | toxin activity |
| B | 0098676 | biological_process | modulation of host virulence by virus |
| C | 0005576 | cellular_component | extracellular region |
| C | 0019836 | biological_process | hemolysis by symbiont of host erythrocytes |
| C | 0090729 | molecular_function | toxin activity |
| C | 0098676 | biological_process | modulation of host virulence by virus |
| D | 0005576 | cellular_component | extracellular region |
| D | 0019836 | biological_process | hemolysis by symbiont of host erythrocytes |
| D | 0090729 | molecular_function | toxin activity |
| D | 0098676 | biological_process | modulation of host virulence by virus |
| E | 0005576 | cellular_component | extracellular region |
| E | 0019836 | biological_process | hemolysis by symbiont of host erythrocytes |
| E | 0090729 | molecular_function | toxin activity |
| E | 0098676 | biological_process | modulation of host virulence by virus |
| F | 0005576 | cellular_component | extracellular region |
| F | 0019836 | biological_process | hemolysis by symbiont of host erythrocytes |
| F | 0090729 | molecular_function | toxin activity |
| F | 0098676 | biological_process | modulation of host virulence by virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 4001 |
| Chain | Residue |
| A | THR22 |
| A | SER25 |
| A | HOH4021 |
| A | HOH4110 |
| A | HOH4168 |
| A | HOH4173 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 4002 |
| Chain | Residue |
| A | FMT3004 |
| A | HOH4035 |
| C | HOH3065 |
| A | ARG266 |
| A | SER278 |
| A | ASN279 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 4003 |
| Chain | Residue |
| A | SER15 |
| A | SER19 |
| A | HOH4078 |
| A | HOH4153 |
| A | HOH4217 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA F 4004 |
| Chain | Residue |
| F | SER53 |
| F | THR55 |
| F | SER60 |
| F | GLY61 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 4005 |
| Chain | Residue |
| B | SER53 |
| B | THR55 |
| B | SER60 |
| B | GLY61 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 1PS F 1001 |
| Chain | Residue |
| F | ASN14 |
| F | ASP16 |
| F | THR18 |
| F | TRP29 |
| F | HOH4018 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1PS B 1002 |
| Chain | Residue |
| B | ASN14 |
| B | ASP16 |
| B | THR18 |
| B | TRP29 |
| B | HOH4010 |
| B | HOH4044 |
| B | HOH4046 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 1PS C 1003 |
| Chain | Residue |
| C | ASN14 |
| C | GLU15 |
| C | ASP16 |
| C | THR18 |
| C | TRP29 |
| C | FMT3012 |
| C | HOH3033 |
| C | HOH3037 |
| C | HOH3057 |
| D | SER58 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 1PS D 1004 |
| Chain | Residue |
| C | SER58 |
| D | ASN14 |
| D | GLU15 |
| D | ASP16 |
| D | THR18 |
| D | TRP29 |
| D | FMT3003 |
| D | HOH3020 |
| D | HOH3040 |
| D | HOH3047 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO F 2001 |
| Chain | Residue |
| A | SER229 |
| A | PHE291 |
| B | TYR13 |
| F | SER31 |
| F | ARG32 |
| F | TRP33 |
| F | ASN34 |
| F | EDO2005 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 2002 |
| Chain | Residue |
| A | THR35 |
| A | LYS288 |
| A | GLY296 |
| A | HOH4059 |
| A | HOH4159 |
| D | TRP33 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 2003 |
| Chain | Residue |
| A | GLN33 |
| A | GLY34 |
| A | THR35 |
| A | THR36 |
| A | LYS288 |
| A | LEU292 |
| A | HOH4159 |
| C | TRP33 |
| C | ASN34 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 2004 |
| Chain | Residue |
| A | PHE3 |
| A | THR4 |
| A | SER16 |
| A | SER19 |
| A | ILE20 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO F 2005 |
| Chain | Residue |
| A | ARG176 |
| A | HOH4235 |
| F | SER31 |
| F | TRP33 |
| F | EDO2001 |
| F | FMT3005 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 3001 |
| Chain | Residue |
| A | GLN175 |
| A | ARG176 |
| A | ARG179 |
| A | HOH4042 |
| F | TRP33 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT E 3002 |
| Chain | Residue |
| E | ARG32 |
| E | TRP33 |
| E | ASN34 |
| E | HOH3033 |
| A | ARG179 |
| A | THR294 |
| A | HOH4105 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT D 3003 |
| Chain | Residue |
| D | THR20 |
| D | GLY59 |
| D | 1PS1004 |
| D | HOH3042 |
| D | HOH3058 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FMT A 3004 |
| Chain | Residue |
| A | ASN207 |
| A | THR263 |
| A | ASP265 |
| A | ARG266 |
| A | PRO267 |
| A | NA4002 |
| A | HOH4142 |
| C | HOH3065 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT F 3005 |
| Chain | Residue |
| A | ASN227 |
| A | SER229 |
| A | ALA230 |
| F | SER31 |
| F | ARG32 |
| F | EDO2005 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT B 3006 |
| Chain | Residue |
| B | ASN68 |
| B | ASN69 |
| B | HOH4026 |
| B | HOH4053 |
| C | ILE8 |
| C | GLU9 |
| C | GLN43 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT C 3007 |
| Chain | Residue |
| C | ARG32 |
| C | TRP33 |
| C | HOH3016 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT E 3008 |
| Chain | Residue |
| A | HOH4090 |
| E | THR30 |
| E | SER31 |
| E | ARG32 |
| E | PHE62 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 3009 |
| Chain | Residue |
| A | ARG266 |
| A | VAL268 |
| A | HOH4106 |
| A | HOH4161 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 3010 |
| Chain | Residue |
| A | THR110 |
| A | VAL120 |
| A | THR149 |
| A | HOH4130 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT F 3011 |
| Chain | Residue |
| E | ASN68 |
| E | ASN69 |
| F | ILE8 |
| F | GLU9 |
| F | GLN43 |
| F | HOH4033 |
| F | HOH4041 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT C 3012 |
| Chain | Residue |
| C | THR20 |
| C | GLY59 |
| C | 1PS1003 |
| C | HOH3034 |
| C | HOH3060 |
| C | HOH3063 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 3013 |
| Chain | Residue |
| A | GLN129 |
| A | ILE130 |
| A | SER131 |
| A | SER134 |
| site_id | DC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT E 3014 |
| Chain | Residue |
| A | ARG219 |
| A | ARG222 |
| E | THR45 |
| E | GLY46 |
| E | MET47 |
| E | ASN69 |
| E | ASP70 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT A 3015 |
| Chain | Residue |
| A | TYR77 |
| A | VAL78 |
| A | SER112 |
| A | VAL162 |
| A | HOH4031 |
| A | HOH4237 |
Functional Information from PROSITE/UniProt
| site_id | PS00275 |
| Number of Residues | 17 |
| Details | SHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. VtVTaEALRFRqIQreF |
| Chain | Residue | Details |
| A | VAL162-PHE178 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU167 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by furin => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG250 |
