1R4C

N-Truncated Human Cystatin C; Dimeric Form With 3D Domain Swapping

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001540	molecular_function	amyloid-beta binding
A	0002020	molecular_function	protease binding
A	0004866	molecular_function	endopeptidase inhibitor activity
A	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0006952	biological_process	defense response
A	0006955	biological_process	immune response
A	0010711	biological_process	negative regulation of collagen catabolic process
A	0010716	biological_process	negative regulation of extracellular matrix disassembly
A	0030414	molecular_function	peptidase inhibitor activity
A	0031982	cellular_component	vesicle
A	0034103	biological_process	regulation of tissue remodeling
A	0042802	molecular_function	identical protein binding
A	0045861	biological_process	negative regulation of proteolysis
A	0060311	biological_process	negative regulation of elastin catabolic process
A	0060313	biological_process	negative regulation of blood vessel remodeling
A	0070062	cellular_component	extracellular exosome
A	0097435	biological_process	supramolecular fiber organization
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0001540	molecular_function	amyloid-beta binding
B	0002020	molecular_function	protease binding
B	0004866	molecular_function	endopeptidase inhibitor activity
B	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0006952	biological_process	defense response
B	0006955	biological_process	immune response
B	0010711	biological_process	negative regulation of collagen catabolic process
B	0010716	biological_process	negative regulation of extracellular matrix disassembly
B	0030414	molecular_function	peptidase inhibitor activity
B	0031982	cellular_component	vesicle
B	0034103	biological_process	regulation of tissue remodeling
B	0042802	molecular_function	identical protein binding
B	0045861	biological_process	negative regulation of proteolysis
B	0060311	biological_process	negative regulation of elastin catabolic process
B	0060313	biological_process	negative regulation of blood vessel remodeling
B	0070062	cellular_component	extracellular exosome
B	0097435	biological_process	supramolecular fiber organization
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0001540	molecular_function	amyloid-beta binding
C	0002020	molecular_function	protease binding
C	0004866	molecular_function	endopeptidase inhibitor activity
C	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0006952	biological_process	defense response
C	0006955	biological_process	immune response
C	0010711	biological_process	negative regulation of collagen catabolic process
C	0010716	biological_process	negative regulation of extracellular matrix disassembly
C	0030414	molecular_function	peptidase inhibitor activity
C	0031982	cellular_component	vesicle
C	0034103	biological_process	regulation of tissue remodeling
C	0042802	molecular_function	identical protein binding
C	0045861	biological_process	negative regulation of proteolysis
C	0060311	biological_process	negative regulation of elastin catabolic process
C	0060313	biological_process	negative regulation of blood vessel remodeling
C	0070062	cellular_component	extracellular exosome
C	0097435	biological_process	supramolecular fiber organization
C	1904724	cellular_component	tertiary granule lumen
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0001540	molecular_function	amyloid-beta binding
D	0002020	molecular_function	protease binding
D	0004866	molecular_function	endopeptidase inhibitor activity
D	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005794	cellular_component	Golgi apparatus
D	0005886	cellular_component	plasma membrane
D	0006952	biological_process	defense response
D	0006955	biological_process	immune response
D	0010711	biological_process	negative regulation of collagen catabolic process
D	0010716	biological_process	negative regulation of extracellular matrix disassembly
D	0030414	molecular_function	peptidase inhibitor activity
D	0031982	cellular_component	vesicle
D	0034103	biological_process	regulation of tissue remodeling
D	0042802	molecular_function	identical protein binding
D	0045861	biological_process	negative regulation of proteolysis
D	0060311	biological_process	negative regulation of elastin catabolic process
D	0060313	biological_process	negative regulation of blood vessel remodeling
D	0070062	cellular_component	extracellular exosome
D	0097435	biological_process	supramolecular fiber organization
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0001540	molecular_function	amyloid-beta binding
E	0002020	molecular_function	protease binding
E	0004866	molecular_function	endopeptidase inhibitor activity
E	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005794	cellular_component	Golgi apparatus
E	0005886	cellular_component	plasma membrane
E	0006952	biological_process	defense response
E	0006955	biological_process	immune response
E	0010711	biological_process	negative regulation of collagen catabolic process
E	0010716	biological_process	negative regulation of extracellular matrix disassembly
E	0030414	molecular_function	peptidase inhibitor activity
E	0031982	cellular_component	vesicle
E	0034103	biological_process	regulation of tissue remodeling
E	0042802	molecular_function	identical protein binding
E	0045861	biological_process	negative regulation of proteolysis
E	0060311	biological_process	negative regulation of elastin catabolic process
E	0060313	biological_process	negative regulation of blood vessel remodeling
E	0070062	cellular_component	extracellular exosome
E	0097435	biological_process	supramolecular fiber organization
E	1904724	cellular_component	tertiary granule lumen
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0001540	molecular_function	amyloid-beta binding
F	0002020	molecular_function	protease binding
F	0004866	molecular_function	endopeptidase inhibitor activity
F	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005794	cellular_component	Golgi apparatus
F	0005886	cellular_component	plasma membrane
F	0006952	biological_process	defense response
F	0006955	biological_process	immune response
F	0010711	biological_process	negative regulation of collagen catabolic process
F	0010716	biological_process	negative regulation of extracellular matrix disassembly
F	0030414	molecular_function	peptidase inhibitor activity
F	0031982	cellular_component	vesicle
F	0034103	biological_process	regulation of tissue remodeling
F	0042802	molecular_function	identical protein binding
F	0045861	biological_process	negative regulation of proteolysis
F	0060311	biological_process	negative regulation of elastin catabolic process
F	0060313	biological_process	negative regulation of blood vessel remodeling
F	0070062	cellular_component	extracellular exosome
F	0097435	biological_process	supramolecular fiber organization
F	1904724	cellular_component	tertiary granule lumen
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0001540	molecular_function	amyloid-beta binding
G	0002020	molecular_function	protease binding
G	0004866	molecular_function	endopeptidase inhibitor activity
G	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005737	cellular_component	cytoplasm
G	0005783	cellular_component	endoplasmic reticulum
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005794	cellular_component	Golgi apparatus
G	0005886	cellular_component	plasma membrane
G	0006952	biological_process	defense response
G	0006955	biological_process	immune response
G	0010711	biological_process	negative regulation of collagen catabolic process
G	0010716	biological_process	negative regulation of extracellular matrix disassembly
G	0030414	molecular_function	peptidase inhibitor activity
G	0031982	cellular_component	vesicle
G	0034103	biological_process	regulation of tissue remodeling
G	0042802	molecular_function	identical protein binding
G	0045861	biological_process	negative regulation of proteolysis
G	0060311	biological_process	negative regulation of elastin catabolic process
G	0060313	biological_process	negative regulation of blood vessel remodeling
G	0070062	cellular_component	extracellular exosome
G	0097435	biological_process	supramolecular fiber organization
G	1904724	cellular_component	tertiary granule lumen
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0001540	molecular_function	amyloid-beta binding
H	0002020	molecular_function	protease binding
H	0004866	molecular_function	endopeptidase inhibitor activity
H	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0005788	cellular_component	endoplasmic reticulum lumen
H	0005794	cellular_component	Golgi apparatus
H	0005886	cellular_component	plasma membrane
H	0006952	biological_process	defense response
H	0006955	biological_process	immune response
H	0010711	biological_process	negative regulation of collagen catabolic process
H	0010716	biological_process	negative regulation of extracellular matrix disassembly
H	0030414	molecular_function	peptidase inhibitor activity
H	0031982	cellular_component	vesicle
H	0034103	biological_process	regulation of tissue remodeling
H	0042802	molecular_function	identical protein binding
H	0045861	biological_process	negative regulation of proteolysis
H	0060311	biological_process	negative regulation of elastin catabolic process
H	0060313	biological_process	negative regulation of blood vessel remodeling
H	0070062	cellular_component	extracellular exosome
H	0097435	biological_process	supramolecular fiber organization
H	1904724	cellular_component	tertiary granule lumen
H	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00287
Number of Residues	14
Details	CYSTATIN Cysteine proteases inhibitors signature. KQIVAGVNYfLDVE

Chain	Residue	Details
A	LYS54-GLU67

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Motif: {"description":"Secondary area of contact"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Site: {"description":"Reactive site"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---