1R3J

potassium channel KcsA-Fab complex in high concentration of Tl+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0030183	biological_process	B cell differentiation
A	0042105	cellular_component	alpha-beta T cell receptor complex
A	0071735	cellular_component	IgG immunoglobulin complex
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0006813	biological_process	potassium ion transport
C	0008076	cellular_component	voltage-gated potassium channel complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TL C 401

Chain	Residue
C	GLY77
C	TL402
C	TL402
C	TL402
C	GLY77
C	GLY77
C	GLY77
C	TYR78
C	TYR78
C	TYR78
C	TYR78
C	TL402

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE TL C 402

Chain	Residue
C	VAL76
C	VAL76
C	VAL76
C	VAL76
C	GLY77
C	GLY77
C	GLY77
C	GLY77
C	TL401
C	TL401
C	TL401
C	TL401
C	TL403
C	TL403
C	TL403
C	TL403

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE TL C 403

Chain	Residue
C	THR75
C	THR75
C	THR75
C	THR75
C	VAL76
C	VAL76
C	VAL76
C	VAL76
C	TL402
C	TL402
C	TL402
C	TL402
C	TL404
C	TL404
C	TL404
C	TL404

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TL C 404

Chain	Residue
C	THR75
C	THR75
C	THR75
C	THR75
C	TL403
C	TL403
C	TL403
C	TL403
C	HOH524
C	HOH524
C	HOH524
C	HOH524

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DGA C 501

Chain	Residue
C	PRO63
C	ARG64
C	VAL84
C	LEU86
C	ARG89
C	HOH505
C	HOH521
C	HOH527

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE F09 B 502

Chain	Residue
B	ARG57
B	HOH582
C	VAL91

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
A	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	97
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	96
Details	Region: {"description":"CH1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	45
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	16
Details	Topological domain: {"description":"Extracellular"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	10
Details	Intramembrane: {"description":"Helical; Pore-forming"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	7
Details	Intramembrane: {"description":"Pore-forming"}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	5
Details	Motif: {"description":"Selectivity filter"}

Chain

Residue

Details

---