1R2Q

Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 300

Chain	Residue
A	SER34
A	THR52
A	GNP200
A	HOH1400
A	HOH1401

---

site_id	AC2
Number of Residues	31
Details	BINDING SITE FOR RESIDUE GNP A 200

Chain	Residue
A	LYS33
A	SER34
A	SER35
A	PHE45
A	HIS46
A	GLU47
A	GLN49
A	SER51
A	THR52
A	GLY78
A	ASN133
A	LYS134
A	ASP136
A	LEU137
A	SER163
A	ALA164
A	LYS165
A	LYS180
A	MG300
A	GOL400
A	HOH1400
A	HOH1401
A	HOH1419
A	HOH1425
A	HOH1430
A	HOH1446
A	HOH1507
A	SER29
A	ALA30
A	VAL31
A	GLY32

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 400

Chain	Residue
A	ALA30
A	GLN49
A	GNP200
A	HOH1425
A	HOH1430
A	HOH1463
A	HOH1592

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 401

Chain	Residue
A	THR103
A	LYS116
A	LYS140
A	GOL404
A	HOH1433
A	HOH1467

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 402

Chain	Residue
A	GLU106
A	ALA109
A	ARG110
A	ASN113
A	ARG141
A	ALA142
A	VAL143
A	ASP144
A	HOH1445
A	HOH1451
A	HOH1604

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 403

Chain	Residue
A	ARG120
A	GLN121
A	GLU172
A	HOH1415
A	HOH1512
A	HOH1569
A	HOH1578

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 404

Chain	Residue
A	ASP101
A	THR103
A	LYS134
A	LEU137
A	LYS140
A	GOL401

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 405

Chain	Residue
A	GLN119
A	ILE126
A	ILE128
A	ASN155
A	HOH1517

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00753","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00753","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12433916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12433916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14684892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15378032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by LRRK2","evidences":[{"source":"PubMed","id":"29125462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"(Microbial infection) N-beta-linked (GlcNAc) arginine","evidences":[{"source":"PubMed","id":"32974215","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN79

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	ALA30

---