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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1QX5

Crystal structure of apoCalmodulin

Functional Information from GO Data
ChainGOidnamespacecontents
B0000086biological_processG2/M transition of mitotic cell cycle
B0000922cellular_componentspindle pole
B0001975biological_processresponse to amphetamine
B0002027biological_processregulation of heart rate
B0005246molecular_functioncalcium channel regulator activity
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005876cellular_componentspindle microtubule
B0005929cellular_componentcilium
B0008076cellular_componentvoltage-gated potassium channel complex
B0008179molecular_functionadenylate cyclase binding
B0010856molecular_functionadenylate cyclase activator activity
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0016020cellular_componentmembrane
B0016240biological_processautophagosome membrane docking
B0019855molecular_functioncalcium channel inhibitor activity
B0019901molecular_functionprotein kinase binding
B0019904molecular_functionprotein domain specific binding
B0030017cellular_componentsarcomere
B0030235molecular_functionnitric-oxide synthase regulator activity
B0030426cellular_componentgrowth cone
B0030672cellular_componentsynaptic vesicle membrane
B0031432molecular_functiontitin binding
B0031514cellular_componentmotile cilium
B0031800molecular_functiontype 3 metabotropic glutamate receptor binding
B0031966cellular_componentmitochondrial membrane
B0031982cellular_componentvesicle
B0032465biological_processregulation of cytokinesis
B0032991cellular_componentprotein-containing complex
B0034704cellular_componentcalcium channel complex
B0035458biological_processcellular response to interferon-beta
B0042995cellular_componentcell projection
B0043209cellular_componentmyelin sheath
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0043548molecular_functionphosphatidylinositol 3-kinase binding
B0044305cellular_componentcalyx of Held
B0044325molecular_functiontransmembrane transporter binding
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050848biological_processregulation of calcium-mediated signaling
B0050998molecular_functionnitric-oxide synthase binding
B0051592biological_processresponse to calcium ion
B0055117biological_processregulation of cardiac muscle contraction
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0071346biological_processcellular response to type II interferon
B0072542molecular_functionprotein phosphatase activator activity
B0090150biological_processestablishment of protein localization to membrane
B0090151biological_processestablishment of protein localization to mitochondrial membrane
B0097225cellular_componentsperm midpiece
B0097720biological_processcalcineurin-mediated signaling
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098901biological_processregulation of cardiac muscle cell action potential
B0099523cellular_componentpresynaptic cytosol
B0099524cellular_componentpostsynaptic cytosol
B0140056biological_processorganelle localization by membrane tethering
B0140238biological_processpresynaptic endocytosis
B0141110molecular_functiontransporter inhibitor activity
B1900242biological_processregulation of synaptic vesicle endocytosis
B1902494cellular_componentcatalytic complex
B1905913biological_processnegative regulation of calcium ion export across plasma membrane
B1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
B2000300biological_processregulation of synaptic vesicle exocytosis
D0000086biological_processG2/M transition of mitotic cell cycle
D0000922cellular_componentspindle pole
D0001975biological_processresponse to amphetamine
D0002027biological_processregulation of heart rate
D0005246molecular_functioncalcium channel regulator activity
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005876cellular_componentspindle microtubule
D0005929cellular_componentcilium
D0008076cellular_componentvoltage-gated potassium channel complex
D0008179molecular_functionadenylate cyclase binding
D0010856molecular_functionadenylate cyclase activator activity
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0016020cellular_componentmembrane
D0016240biological_processautophagosome membrane docking
D0019855molecular_functioncalcium channel inhibitor activity
D0019901molecular_functionprotein kinase binding
D0019904molecular_functionprotein domain specific binding
D0030017cellular_componentsarcomere
D0030235molecular_functionnitric-oxide synthase regulator activity
D0030426cellular_componentgrowth cone
D0030672cellular_componentsynaptic vesicle membrane
D0031432molecular_functiontitin binding
D0031514cellular_componentmotile cilium
D0031800molecular_functiontype 3 metabotropic glutamate receptor binding
D0031966cellular_componentmitochondrial membrane
D0031982cellular_componentvesicle
D0032465biological_processregulation of cytokinesis
D0032991cellular_componentprotein-containing complex
D0034704cellular_componentcalcium channel complex
D0035458biological_processcellular response to interferon-beta
D0042995cellular_componentcell projection
D0043209cellular_componentmyelin sheath
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0043548molecular_functionphosphatidylinositol 3-kinase binding
D0044305cellular_componentcalyx of Held
D0044325molecular_functiontransmembrane transporter binding
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050848biological_processregulation of calcium-mediated signaling
D0050998molecular_functionnitric-oxide synthase binding
D0051592biological_processresponse to calcium ion
D0055117biological_processregulation of cardiac muscle contraction
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0071346biological_processcellular response to type II interferon
D0072542molecular_functionprotein phosphatase activator activity
D0090150biological_processestablishment of protein localization to membrane
D0090151biological_processestablishment of protein localization to mitochondrial membrane
D0097225cellular_componentsperm midpiece
D0097720biological_processcalcineurin-mediated signaling
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098901biological_processregulation of cardiac muscle cell action potential
D0099523cellular_componentpresynaptic cytosol
D0099524cellular_componentpostsynaptic cytosol
D0140056biological_processorganelle localization by membrane tethering
D0140238biological_processpresynaptic endocytosis
D0141110molecular_functiontransporter inhibitor activity
D1900242biological_processregulation of synaptic vesicle endocytosis
D1902494cellular_componentcatalytic complex
D1905913biological_processnegative regulation of calcium ion export across plasma membrane
D1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
D2000300biological_processregulation of synaptic vesicle exocytosis
I0000086biological_processG2/M transition of mitotic cell cycle
I0000922cellular_componentspindle pole
I0001975biological_processresponse to amphetamine
I0002027biological_processregulation of heart rate
I0005246molecular_functioncalcium channel regulator activity
I0005509molecular_functioncalcium ion binding
I0005513biological_processdetection of calcium ion
I0005515molecular_functionprotein binding
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005813cellular_componentcentrosome
I0005819cellular_componentspindle
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005876cellular_componentspindle microtubule
I0005929cellular_componentcilium
I0008076cellular_componentvoltage-gated potassium channel complex
I0008179molecular_functionadenylate cyclase binding
I0010856molecular_functionadenylate cyclase activator activity
I0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I0016020cellular_componentmembrane
I0016240biological_processautophagosome membrane docking
I0019855molecular_functioncalcium channel inhibitor activity
I0019901molecular_functionprotein kinase binding
I0019904molecular_functionprotein domain specific binding
I0030017cellular_componentsarcomere
I0030235molecular_functionnitric-oxide synthase regulator activity
I0030426cellular_componentgrowth cone
I0030672cellular_componentsynaptic vesicle membrane
I0031432molecular_functiontitin binding
I0031514cellular_componentmotile cilium
I0031800molecular_functiontype 3 metabotropic glutamate receptor binding
I0031966cellular_componentmitochondrial membrane
I0031982cellular_componentvesicle
I0032465biological_processregulation of cytokinesis
I0032991cellular_componentprotein-containing complex
I0034704cellular_componentcalcium channel complex
I0035458biological_processcellular response to interferon-beta
I0042995cellular_componentcell projection
I0043209cellular_componentmyelin sheath
I0043539molecular_functionprotein serine/threonine kinase activator activity
I0043548molecular_functionphosphatidylinositol 3-kinase binding
I0044305cellular_componentcalyx of Held
I0044325molecular_functiontransmembrane transporter binding
I0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
I0046872molecular_functionmetal ion binding
I0048306molecular_functioncalcium-dependent protein binding
I0050848biological_processregulation of calcium-mediated signaling
I0050998molecular_functionnitric-oxide synthase binding
I0051592biological_processresponse to calcium ion
I0055117biological_processregulation of cardiac muscle contraction
I0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
I0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
I0071346biological_processcellular response to type II interferon
I0072542molecular_functionprotein phosphatase activator activity
I0090150biological_processestablishment of protein localization to membrane
I0090151biological_processestablishment of protein localization to mitochondrial membrane
I0097225cellular_componentsperm midpiece
I0097720biological_processcalcineurin-mediated signaling
I0098685cellular_componentSchaffer collateral - CA1 synapse
I0098901biological_processregulation of cardiac muscle cell action potential
I0099523cellular_componentpresynaptic cytosol
I0099524cellular_componentpostsynaptic cytosol
I0140056biological_processorganelle localization by membrane tethering
I0140238biological_processpresynaptic endocytosis
I0141110molecular_functiontransporter inhibitor activity
I1900242biological_processregulation of synaptic vesicle endocytosis
I1902494cellular_componentcatalytic complex
I1905913biological_processnegative regulation of calcium ion export across plasma membrane
I1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
I2000300biological_processregulation of synaptic vesicle exocytosis
J0000086biological_processG2/M transition of mitotic cell cycle
J0000922cellular_componentspindle pole
J0001975biological_processresponse to amphetamine
J0002027biological_processregulation of heart rate
J0005246molecular_functioncalcium channel regulator activity
J0005509molecular_functioncalcium ion binding
J0005513biological_processdetection of calcium ion
J0005515molecular_functionprotein binding
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005813cellular_componentcentrosome
J0005819cellular_componentspindle
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005876cellular_componentspindle microtubule
J0005929cellular_componentcilium
J0008076cellular_componentvoltage-gated potassium channel complex
J0008179molecular_functionadenylate cyclase binding
J0010856molecular_functionadenylate cyclase activator activity
J0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J0016020cellular_componentmembrane
J0016240biological_processautophagosome membrane docking
J0019855molecular_functioncalcium channel inhibitor activity
J0019901molecular_functionprotein kinase binding
J0019904molecular_functionprotein domain specific binding
J0030017cellular_componentsarcomere
J0030235molecular_functionnitric-oxide synthase regulator activity
J0030426cellular_componentgrowth cone
J0030672cellular_componentsynaptic vesicle membrane
J0031432molecular_functiontitin binding
J0031514cellular_componentmotile cilium
J0031800molecular_functiontype 3 metabotropic glutamate receptor binding
J0031966cellular_componentmitochondrial membrane
J0031982cellular_componentvesicle
J0032465biological_processregulation of cytokinesis
J0032991cellular_componentprotein-containing complex
J0034704cellular_componentcalcium channel complex
J0035458biological_processcellular response to interferon-beta
J0042995cellular_componentcell projection
J0043209cellular_componentmyelin sheath
J0043539molecular_functionprotein serine/threonine kinase activator activity
J0043548molecular_functionphosphatidylinositol 3-kinase binding
J0044305cellular_componentcalyx of Held
J0044325molecular_functiontransmembrane transporter binding
J0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
J0046872molecular_functionmetal ion binding
J0048306molecular_functioncalcium-dependent protein binding
J0050848biological_processregulation of calcium-mediated signaling
J0050998molecular_functionnitric-oxide synthase binding
J0051592biological_processresponse to calcium ion
J0055117biological_processregulation of cardiac muscle contraction
J0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
J0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
J0071346biological_processcellular response to type II interferon
J0072542molecular_functionprotein phosphatase activator activity
J0090150biological_processestablishment of protein localization to membrane
J0090151biological_processestablishment of protein localization to mitochondrial membrane
J0097225cellular_componentsperm midpiece
J0097720biological_processcalcineurin-mediated signaling
J0098685cellular_componentSchaffer collateral - CA1 synapse
J0098901biological_processregulation of cardiac muscle cell action potential
J0099523cellular_componentpresynaptic cytosol
J0099524cellular_componentpostsynaptic cytosol
J0140056biological_processorganelle localization by membrane tethering
J0140238biological_processpresynaptic endocytosis
J0141110molecular_functiontransporter inhibitor activity
J1900242biological_processregulation of synaptic vesicle endocytosis
J1902494cellular_componentcatalytic complex
J1905913biological_processnegative regulation of calcium ion export across plasma membrane
J1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
J2000300biological_processregulation of synaptic vesicle exocytosis
K0000086biological_processG2/M transition of mitotic cell cycle
K0000922cellular_componentspindle pole
K0001975biological_processresponse to amphetamine
K0002027biological_processregulation of heart rate
K0005246molecular_functioncalcium channel regulator activity
K0005509molecular_functioncalcium ion binding
K0005513biological_processdetection of calcium ion
K0005515molecular_functionprotein binding
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005813cellular_componentcentrosome
K0005819cellular_componentspindle
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005876cellular_componentspindle microtubule
K0005929cellular_componentcilium
K0008076cellular_componentvoltage-gated potassium channel complex
K0008179molecular_functionadenylate cyclase binding
K0010856molecular_functionadenylate cyclase activator activity
K0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K0016020cellular_componentmembrane
K0016240biological_processautophagosome membrane docking
K0019855molecular_functioncalcium channel inhibitor activity
K0019901molecular_functionprotein kinase binding
K0019904molecular_functionprotein domain specific binding
K0030017cellular_componentsarcomere
K0030235molecular_functionnitric-oxide synthase regulator activity
K0030426cellular_componentgrowth cone
K0030672cellular_componentsynaptic vesicle membrane
K0031432molecular_functiontitin binding
K0031514cellular_componentmotile cilium
K0031800molecular_functiontype 3 metabotropic glutamate receptor binding
K0031966cellular_componentmitochondrial membrane
K0031982cellular_componentvesicle
K0032465biological_processregulation of cytokinesis
K0032991cellular_componentprotein-containing complex
K0034704cellular_componentcalcium channel complex
K0035458biological_processcellular response to interferon-beta
K0042995cellular_componentcell projection
K0043209cellular_componentmyelin sheath
K0043539molecular_functionprotein serine/threonine kinase activator activity
K0043548molecular_functionphosphatidylinositol 3-kinase binding
K0044305cellular_componentcalyx of Held
K0044325molecular_functiontransmembrane transporter binding
K0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
K0046872molecular_functionmetal ion binding
K0048306molecular_functioncalcium-dependent protein binding
K0050848biological_processregulation of calcium-mediated signaling
K0050998molecular_functionnitric-oxide synthase binding
K0051592biological_processresponse to calcium ion
K0055117biological_processregulation of cardiac muscle contraction
K0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
K0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
K0071346biological_processcellular response to type II interferon
K0072542molecular_functionprotein phosphatase activator activity
K0090150biological_processestablishment of protein localization to membrane
K0090151biological_processestablishment of protein localization to mitochondrial membrane
K0097225cellular_componentsperm midpiece
K0097720biological_processcalcineurin-mediated signaling
K0098685cellular_componentSchaffer collateral - CA1 synapse
K0098901biological_processregulation of cardiac muscle cell action potential
K0099523cellular_componentpresynaptic cytosol
K0099524cellular_componentpostsynaptic cytosol
K0140056biological_processorganelle localization by membrane tethering
K0140238biological_processpresynaptic endocytosis
K0141110molecular_functiontransporter inhibitor activity
K1900242biological_processregulation of synaptic vesicle endocytosis
K1902494cellular_componentcatalytic complex
K1905913biological_processnegative regulation of calcium ion export across plasma membrane
K1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
K2000300biological_processregulation of synaptic vesicle exocytosis
R0000086biological_processG2/M transition of mitotic cell cycle
R0000922cellular_componentspindle pole
R0001975biological_processresponse to amphetamine
R0002027biological_processregulation of heart rate
R0005246molecular_functioncalcium channel regulator activity
R0005509molecular_functioncalcium ion binding
R0005513biological_processdetection of calcium ion
R0005515molecular_functionprotein binding
R0005654cellular_componentnucleoplasm
R0005737cellular_componentcytoplasm
R0005739cellular_componentmitochondrion
R0005813cellular_componentcentrosome
R0005819cellular_componentspindle
R0005829cellular_componentcytosol
R0005856cellular_componentcytoskeleton
R0005876cellular_componentspindle microtubule
R0005929cellular_componentcilium
R0008076cellular_componentvoltage-gated potassium channel complex
R0008179molecular_functionadenylate cyclase binding
R0010856molecular_functionadenylate cyclase activator activity
R0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
R0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
R0016020cellular_componentmembrane
R0016240biological_processautophagosome membrane docking
R0019855molecular_functioncalcium channel inhibitor activity
R0019901molecular_functionprotein kinase binding
R0019904molecular_functionprotein domain specific binding
R0030017cellular_componentsarcomere
R0030235molecular_functionnitric-oxide synthase regulator activity
R0030426cellular_componentgrowth cone
R0030672cellular_componentsynaptic vesicle membrane
R0031432molecular_functiontitin binding
R0031514cellular_componentmotile cilium
R0031800molecular_functiontype 3 metabotropic glutamate receptor binding
R0031966cellular_componentmitochondrial membrane
R0031982cellular_componentvesicle
R0032465biological_processregulation of cytokinesis
R0032991cellular_componentprotein-containing complex
R0034704cellular_componentcalcium channel complex
R0035458biological_processcellular response to interferon-beta
R0042995cellular_componentcell projection
R0043209cellular_componentmyelin sheath
R0043539molecular_functionprotein serine/threonine kinase activator activity
R0043548molecular_functionphosphatidylinositol 3-kinase binding
R0044305cellular_componentcalyx of Held
R0044325molecular_functiontransmembrane transporter binding
R0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
R0046872molecular_functionmetal ion binding
R0048306molecular_functioncalcium-dependent protein binding
R0050848biological_processregulation of calcium-mediated signaling
R0050998molecular_functionnitric-oxide synthase binding
R0051592biological_processresponse to calcium ion
R0055117biological_processregulation of cardiac muscle contraction
R0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
R0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
R0071346biological_processcellular response to type II interferon
R0072542molecular_functionprotein phosphatase activator activity
R0090150biological_processestablishment of protein localization to membrane
R0090151biological_processestablishment of protein localization to mitochondrial membrane
R0097225cellular_componentsperm midpiece
R0097720biological_processcalcineurin-mediated signaling
R0098685cellular_componentSchaffer collateral - CA1 synapse
R0098901biological_processregulation of cardiac muscle cell action potential
R0099523cellular_componentpresynaptic cytosol
R0099524cellular_componentpostsynaptic cytosol
R0140056biological_processorganelle localization by membrane tethering
R0140238biological_processpresynaptic endocytosis
R0141110molecular_functiontransporter inhibitor activity
R1900242biological_processregulation of synaptic vesicle endocytosis
R1902494cellular_componentcatalytic complex
R1905913biological_processnegative regulation of calcium ion export across plasma membrane
R1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
R2000300biological_processregulation of synaptic vesicle exocytosis
T0000086biological_processG2/M transition of mitotic cell cycle
T0000922cellular_componentspindle pole
T0001975biological_processresponse to amphetamine
T0002027biological_processregulation of heart rate
T0005246molecular_functioncalcium channel regulator activity
T0005509molecular_functioncalcium ion binding
T0005513biological_processdetection of calcium ion
T0005515molecular_functionprotein binding
T0005654cellular_componentnucleoplasm
T0005737cellular_componentcytoplasm
T0005739cellular_componentmitochondrion
T0005813cellular_componentcentrosome
T0005819cellular_componentspindle
T0005829cellular_componentcytosol
T0005856cellular_componentcytoskeleton
T0005876cellular_componentspindle microtubule
T0005929cellular_componentcilium
T0008076cellular_componentvoltage-gated potassium channel complex
T0008179molecular_functionadenylate cyclase binding
T0010856molecular_functionadenylate cyclase activator activity
T0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
T0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
T0016020cellular_componentmembrane
T0016240biological_processautophagosome membrane docking
T0019855molecular_functioncalcium channel inhibitor activity
T0019901molecular_functionprotein kinase binding
T0019904molecular_functionprotein domain specific binding
T0030017cellular_componentsarcomere
T0030235molecular_functionnitric-oxide synthase regulator activity
T0030426cellular_componentgrowth cone
T0030672cellular_componentsynaptic vesicle membrane
T0031432molecular_functiontitin binding
T0031514cellular_componentmotile cilium
T0031800molecular_functiontype 3 metabotropic glutamate receptor binding
T0031966cellular_componentmitochondrial membrane
T0031982cellular_componentvesicle
T0032465biological_processregulation of cytokinesis
T0032991cellular_componentprotein-containing complex
T0034704cellular_componentcalcium channel complex
T0035458biological_processcellular response to interferon-beta
T0042995cellular_componentcell projection
T0043209cellular_componentmyelin sheath
T0043539molecular_functionprotein serine/threonine kinase activator activity
T0043548molecular_functionphosphatidylinositol 3-kinase binding
T0044305cellular_componentcalyx of Held
T0044325molecular_functiontransmembrane transporter binding
T0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
T0046872molecular_functionmetal ion binding
T0048306molecular_functioncalcium-dependent protein binding
T0050848biological_processregulation of calcium-mediated signaling
T0050998molecular_functionnitric-oxide synthase binding
T0051592biological_processresponse to calcium ion
T0055117biological_processregulation of cardiac muscle contraction
T0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
T0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
T0071346biological_processcellular response to type II interferon
T0072542molecular_functionprotein phosphatase activator activity
T0090150biological_processestablishment of protein localization to membrane
T0090151biological_processestablishment of protein localization to mitochondrial membrane
T0097225cellular_componentsperm midpiece
T0097720biological_processcalcineurin-mediated signaling
T0098685cellular_componentSchaffer collateral - CA1 synapse
T0098901biological_processregulation of cardiac muscle cell action potential
T0099523cellular_componentpresynaptic cytosol
T0099524cellular_componentpostsynaptic cytosol
T0140056biological_processorganelle localization by membrane tethering
T0140238biological_processpresynaptic endocytosis
T0141110molecular_functiontransporter inhibitor activity
T1900242biological_processregulation of synaptic vesicle endocytosis
T1902494cellular_componentcatalytic complex
T1905913biological_processnegative regulation of calcium ion export across plasma membrane
T1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
T2000300biological_processregulation of synaptic vesicle exocytosis
Y0000086biological_processG2/M transition of mitotic cell cycle
Y0000922cellular_componentspindle pole
Y0001975biological_processresponse to amphetamine
Y0002027biological_processregulation of heart rate
Y0005246molecular_functioncalcium channel regulator activity
Y0005509molecular_functioncalcium ion binding
Y0005513biological_processdetection of calcium ion
Y0005515molecular_functionprotein binding
Y0005654cellular_componentnucleoplasm
Y0005737cellular_componentcytoplasm
Y0005739cellular_componentmitochondrion
Y0005813cellular_componentcentrosome
Y0005819cellular_componentspindle
Y0005829cellular_componentcytosol
Y0005856cellular_componentcytoskeleton
Y0005876cellular_componentspindle microtubule
Y0005929cellular_componentcilium
Y0008076cellular_componentvoltage-gated potassium channel complex
Y0008179molecular_functionadenylate cyclase binding
Y0010856molecular_functionadenylate cyclase activator activity
Y0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Y0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Y0016020cellular_componentmembrane
Y0016240biological_processautophagosome membrane docking
Y0019855molecular_functioncalcium channel inhibitor activity
Y0019901molecular_functionprotein kinase binding
Y0019904molecular_functionprotein domain specific binding
Y0030017cellular_componentsarcomere
Y0030235molecular_functionnitric-oxide synthase regulator activity
Y0030426cellular_componentgrowth cone
Y0030672cellular_componentsynaptic vesicle membrane
Y0031432molecular_functiontitin binding
Y0031514cellular_componentmotile cilium
Y0031800molecular_functiontype 3 metabotropic glutamate receptor binding
Y0031966cellular_componentmitochondrial membrane
Y0031982cellular_componentvesicle
Y0032465biological_processregulation of cytokinesis
Y0032991cellular_componentprotein-containing complex
Y0034704cellular_componentcalcium channel complex
Y0035458biological_processcellular response to interferon-beta
Y0042995cellular_componentcell projection
Y0043209cellular_componentmyelin sheath
Y0043539molecular_functionprotein serine/threonine kinase activator activity
Y0043548molecular_functionphosphatidylinositol 3-kinase binding
Y0044305cellular_componentcalyx of Held
Y0044325molecular_functiontransmembrane transporter binding
Y0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
Y0046872molecular_functionmetal ion binding
Y0048306molecular_functioncalcium-dependent protein binding
Y0050848biological_processregulation of calcium-mediated signaling
Y0050998molecular_functionnitric-oxide synthase binding
Y0051592biological_processresponse to calcium ion
Y0055117biological_processregulation of cardiac muscle contraction
Y0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
Y0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
Y0071346biological_processcellular response to type II interferon
Y0072542molecular_functionprotein phosphatase activator activity
Y0090150biological_processestablishment of protein localization to membrane
Y0090151biological_processestablishment of protein localization to mitochondrial membrane
Y0097225cellular_componentsperm midpiece
Y0097720biological_processcalcineurin-mediated signaling
Y0098685cellular_componentSchaffer collateral - CA1 synapse
Y0098901biological_processregulation of cardiac muscle cell action potential
Y0099523cellular_componentpresynaptic cytosol
Y0099524cellular_componentpostsynaptic cytosol
Y0140056biological_processorganelle localization by membrane tethering
Y0140238biological_processpresynaptic endocytosis
Y0141110molecular_functiontransporter inhibitor activity
Y1900242biological_processregulation of synaptic vesicle endocytosis
Y1902494cellular_componentcatalytic complex
Y1905913biological_processnegative regulation of calcium ion export across plasma membrane
Y1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Y2000300biological_processregulation of synaptic vesicle exocytosis
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
DASP20-LEU32
DASP56-PHE68
DASP93-LEU105
DASP129-PHE141
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues280
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues280
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues280
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11323678","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23109337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3145979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G4Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HQW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CLN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IFK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G27","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J9Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11323678","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23109337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3145979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G4Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HQW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CLN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IFK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G27","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J9Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23109337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3145979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HQW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CLN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RJD","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23109337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3145979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HQW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CLN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RJD","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsModified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"PubMed","id":"12392717","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues8
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues8
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues8
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues16
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues32
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues72
DetailsRegion: {"description":"Necessary and sufficient for interaction with PCP4","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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