1QSM

Histone Acetyltransferase HPA2 from Saccharomyces Cerevisiae in Complex with Acetyl Coenzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004059	molecular_function	aralkylamine N-acetyltransferase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006325	biological_process	chromatin organization
A	0006473	biological_process	protein acetylation
A	0008080	molecular_function	N-acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0032917	biological_process	polyamine acetylation
A	0042802	molecular_function	identical protein binding
A	0061733	molecular_function	protein-lysine-acetyltransferase activity
B	0004059	molecular_function	aralkylamine N-acetyltransferase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006325	biological_process	chromatin organization
B	0006473	biological_process	protein acetylation
B	0008080	molecular_function	N-acetyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0032917	biological_process	polyamine acetylation
B	0042802	molecular_function	identical protein binding
B	0061733	molecular_function	protein-lysine-acetyltransferase activity
C	0004059	molecular_function	aralkylamine N-acetyltransferase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006325	biological_process	chromatin organization
C	0006473	biological_process	protein acetylation
C	0008080	molecular_function	N-acetyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0032917	biological_process	polyamine acetylation
C	0042802	molecular_function	identical protein binding
C	0061733	molecular_function	protein-lysine-acetyltransferase activity
D	0004059	molecular_function	aralkylamine N-acetyltransferase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006325	biological_process	chromatin organization
D	0006473	biological_process	protein acetylation
D	0008080	molecular_function	N-acetyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0032917	biological_process	polyamine acetylation
D	0042802	molecular_function	identical protein binding
D	0061733	molecular_function	protein-lysine-acetyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ACO A 1200

Chain	Residue
A	TYR29
A	GLY105
A	GLY106
A	CYS127
A	THR128
A	ASN132
A	ARG134
A	ALA135
A	LEU137
A	LEU138
A	TYR139
A	PHE32
A	LYS141
A	HOH1204
A	HOH1216
A	HOH1219
A	HOH1223
A	HOH1253
C	ACO1202
A	LEU93
A	TYR94
A	VAL95
A	ARG100
A	VAL101
A	LYS102
A	GLY103

---

site_id	AC2
Number of Residues	29
Details	BINDING SITE FOR RESIDUE ACO B 1201

Chain	Residue
B	TYR29
B	PHE32
B	TYR33
B	ASN91
B	LEU93
B	TYR94
B	VAL95
B	ARG100
B	VAL101
B	LYS102
B	GLY103
B	ALA104
B	GLY105
B	GLY106
B	CYS127
B	THR128
B	ASN132
B	ARG134
B	ALA135
B	LEU138
B	TYR139
B	LYS141
B	HOH1217
B	HOH1221
B	HOH1240
B	HOH1242
B	HOH1243
D	ARG134
D	ACO1203

---

site_id	AC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ACO C 1202

Chain	Residue
A	ARG134
A	ACO1200
C	TYR29
C	PHE32
C	TYR33
C	LEU93
C	VAL95
C	ARG100
C	VAL101
C	LYS102
C	GLY103
C	ALA104
C	GLY105
C	GLY106
C	CYS127
C	THR128
C	ASN132
C	ARG134
C	ALA135
C	LEU137
C	LEU138
C	TYR139
C	LYS141
C	HOH1215
C	HOH1243
C	HOH1246

---

site_id	AC4
Number of Residues	28
Details	BINDING SITE FOR RESIDUE ACO D 1203

Chain	Residue
D	ALA135
D	LEU137
D	LEU138
D	TYR139
D	LYS141
D	HOH1216
D	HOH1228
D	HOH1234
D	HOH1236
D	HOH1248
B	ACO1201
D	TYR29
D	PHE32
D	TYR33
D	LEU93
D	TYR94
D	VAL95
D	ARG100
D	VAL101
D	LYS102
D	GLY103
D	ALA104
D	GLY105
D	GLY106
D	CYS127
D	THR128
D	ASN132
D	ARG134

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	588
Details	Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	52
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10600387","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"10600387","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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