1QSM
Histone Acetyltransferase HPA2 from Saccharomyces Cerevisiae in Complex with Acetyl Coenzyme A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004059 | molecular_function | aralkylamine N-acetyltransferase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006473 | biological_process | protein acetylation |
| A | 0008080 | molecular_function | N-acetyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0061733 | molecular_function | protein-lysine-acetyltransferase activity |
| A | 1990331 | cellular_component | Hpa2 acetyltransferase complex |
| B | 0004059 | molecular_function | aralkylamine N-acetyltransferase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006473 | biological_process | protein acetylation |
| B | 0008080 | molecular_function | N-acetyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0061733 | molecular_function | protein-lysine-acetyltransferase activity |
| B | 1990331 | cellular_component | Hpa2 acetyltransferase complex |
| C | 0004059 | molecular_function | aralkylamine N-acetyltransferase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006473 | biological_process | protein acetylation |
| C | 0008080 | molecular_function | N-acetyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0061733 | molecular_function | protein-lysine-acetyltransferase activity |
| C | 1990331 | cellular_component | Hpa2 acetyltransferase complex |
| D | 0004059 | molecular_function | aralkylamine N-acetyltransferase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006473 | biological_process | protein acetylation |
| D | 0008080 | molecular_function | N-acetyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0061733 | molecular_function | protein-lysine-acetyltransferase activity |
| D | 1990331 | cellular_component | Hpa2 acetyltransferase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE ACO A 1200 |
| Chain | Residue |
| A | TYR29 |
| A | GLY105 |
| A | GLY106 |
| A | CYS127 |
| A | THR128 |
| A | ASN132 |
| A | ARG134 |
| A | ALA135 |
| A | LEU137 |
| A | LEU138 |
| A | TYR139 |
| A | PHE32 |
| A | LYS141 |
| A | HOH1204 |
| A | HOH1216 |
| A | HOH1219 |
| A | HOH1223 |
| A | HOH1253 |
| C | ACO1202 |
| A | LEU93 |
| A | TYR94 |
| A | VAL95 |
| A | ARG100 |
| A | VAL101 |
| A | LYS102 |
| A | GLY103 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE ACO B 1201 |
| Chain | Residue |
| B | TYR29 |
| B | PHE32 |
| B | TYR33 |
| B | ASN91 |
| B | LEU93 |
| B | TYR94 |
| B | VAL95 |
| B | ARG100 |
| B | VAL101 |
| B | LYS102 |
| B | GLY103 |
| B | ALA104 |
| B | GLY105 |
| B | GLY106 |
| B | CYS127 |
| B | THR128 |
| B | ASN132 |
| B | ARG134 |
| B | ALA135 |
| B | LEU138 |
| B | TYR139 |
| B | LYS141 |
| B | HOH1217 |
| B | HOH1221 |
| B | HOH1240 |
| B | HOH1242 |
| B | HOH1243 |
| D | ARG134 |
| D | ACO1203 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE ACO C 1202 |
| Chain | Residue |
| A | ARG134 |
| A | ACO1200 |
| C | TYR29 |
| C | PHE32 |
| C | TYR33 |
| C | LEU93 |
| C | VAL95 |
| C | ARG100 |
| C | VAL101 |
| C | LYS102 |
| C | GLY103 |
| C | ALA104 |
| C | GLY105 |
| C | GLY106 |
| C | CYS127 |
| C | THR128 |
| C | ASN132 |
| C | ARG134 |
| C | ALA135 |
| C | LEU137 |
| C | LEU138 |
| C | TYR139 |
| C | LYS141 |
| C | HOH1215 |
| C | HOH1243 |
| C | HOH1246 |
| site_id | AC4 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE ACO D 1203 |
| Chain | Residue |
| D | ALA135 |
| D | LEU137 |
| D | LEU138 |
| D | TYR139 |
| D | LYS141 |
| D | HOH1216 |
| D | HOH1228 |
| D | HOH1234 |
| D | HOH1236 |
| D | HOH1248 |
| B | ACO1201 |
| D | TYR29 |
| D | PHE32 |
| D | TYR33 |
| D | LEU93 |
| D | TYR94 |
| D | VAL95 |
| D | ARG100 |
| D | VAL101 |
| D | LYS102 |
| D | GLY103 |
| D | ALA104 |
| D | GLY105 |
| D | GLY106 |
| D | CYS127 |
| D | THR128 |
| D | ASN132 |
| D | ARG134 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 588 |
| Details | Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10600387","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"10600387","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
