Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0006508 | biological_process | proteolysis |
B | 0004252 | molecular_function | serine-type endopeptidase activity |
B | 0006508 | biological_process | proteolysis |
C | 0004252 | molecular_function | serine-type endopeptidase activity |
C | 0006508 | biological_process | proteolysis |
D | 0004252 | molecular_function | serine-type endopeptidase activity |
D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
site_id | ACA |
Number of Residues | 3 |
Details | ACTIVE SITE FOR CHAIN A. |
Chain | Residue |
A | ASP646 |
A | HIS603 |
A | SER741 |
site_id | ACB |
Number of Residues | 3 |
Details | ACTIVE SITE FOR CHAIN B. |
Chain | Residue |
B | ASP646 |
B | HIS603 |
B | SER741 |
site_id | ACC |
Number of Residues | 3 |
Details | ACTIVE SITE FOR CHAIN C. |
Chain | Residue |
C | ASP646 |
C | HIS603 |
C | SER741 |
site_id | ACD |
Number of Residues | 3 |
Details | ACTIVE SITE FOR CHAIN D. |
Chain | Residue |
D | ASP646 |
D | HIS603 |
D | SER741 |
Functional Information from PROSITE/UniProt
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
Chain | Residue | Details |
A | LEU599-CYS604 | |
site_id | PS00135 |
Number of Residues | 12 |
Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV |
Chain | Residue | Details |
A | ASP735-VAL746 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: Charge relay system |
Chain | Residue | Details |
A | HIS603 | |
D | HIS603 | |
D | ASP646 | |
D | SER741 | |
A | ASP646 | |
A | SER741 | |
B | HIS603 | |
B | ASP646 | |
B | SER741 | |
C | HIS603 | |
C | ASP646 | |
C | SER741 | |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Cleavage; by plasminogen activator |
Chain | Residue | Details |
A | ARG561 | |
B | ARG561 | |
C | ARG561 | |
D | ARG561 | |
Chain | Residue | Details |
A | SER578 | |
B | SER578 | |
C | SER578 | |
D | SER578 | |
Chain | Residue | Details |
A | SER669 | |
B | SER669 | |
C | SER669 | |
D | SER669 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 5 |
Details | a catalytic site defined by CSA, PubMed 10460175, 9783753, 10390345 |
Chain | Residue | Details |
A | HIS603 | |
A | SER741 | |
A | SER741 | |
A | ASP646 | |
A | GLY742 | |
site_id | CSA2 |
Number of Residues | 5 |
Details | a catalytic site defined by CSA, PubMed 10460175, 9783753, 10390345 |
Chain | Residue | Details |
B | HIS603 | |
B | SER741 | |
B | SER741 | |
B | ASP646 | |
B | GLY742 | |
site_id | CSA3 |
Number of Residues | 5 |
Details | a catalytic site defined by CSA, PubMed 10460175, 9783753, 10390345 |
Chain | Residue | Details |
C | HIS603 | |
C | SER741 | |
C | SER741 | |
C | ASP646 | |
C | GLY742 | |
site_id | CSA4 |
Number of Residues | 5 |
Details | a catalytic site defined by CSA, PubMed 10460175, 9783753, 10390345 |
Chain | Residue | Details |
D | HIS603 | |
D | SER741 | |
D | SER741 | |
D | ASP646 | |
D | GLY742 | |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 425 |
Chain | Residue | Details |
A | HIS603 | proton shuttle (general acid/base) |
A | ASP646 | electrostatic stabiliser, modifies pKa |
A | SER741 | covalent catalysis, proton shuttle (general acid/base) |
A | GLY742 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 425 |
Chain | Residue | Details |
B | HIS603 | proton shuttle (general acid/base) |
B | ASP646 | electrostatic stabiliser, modifies pKa |
B | SER741 | covalent catalysis, proton shuttle (general acid/base) |
B | GLY742 | electrostatic stabiliser |
site_id | MCSA3 |
Number of Residues | 4 |
Details | M-CSA 425 |
Chain | Residue | Details |
C | HIS603 | proton shuttle (general acid/base) |
C | ASP646 | electrostatic stabiliser, modifies pKa |
C | SER741 | covalent catalysis, proton shuttle (general acid/base) |
C | GLY742 | electrostatic stabiliser |
site_id | MCSA4 |
Number of Residues | 4 |
Details | M-CSA 425 |
Chain | Residue | Details |
D | HIS603 | proton shuttle (general acid/base) |
D | ASP646 | electrostatic stabiliser, modifies pKa |
D | SER741 | covalent catalysis, proton shuttle (general acid/base) |
D | GLY742 | electrostatic stabiliser |