1QPC

STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 901

Chain	Residue
A	GLN298
A	ARG299
A	SER377
A	LYS379
A	TYR457
A	ARG458
A	ARG474
A	HOH912
A	HOH1147

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 902

Chain	Residue
A	THR330
A	PRO331
A	SER332
A	ARG358
A	HOH943
A	HOH1026

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 903

Chain	Residue
A	PRO409
A	ILE412
A	ASN413
A	ILE450
A	LEU453
A	GLU454

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site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ANP A 904

Chain	Residue
A	LEU251
A	VAL259
A	ALA271
A	THR316
A	GLU317
A	MET319
A	SER323
A	LEU371
A	HOH940
A	HOH987
A	HOH1035
A	HOH1067
A	HOH1073
A	HOH1134

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site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 905

Chain	Residue
A	LYS273
A	GLU288
A	ALA381
A	ASP382
A	HOH1033
A	HOH1035

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	23
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGQFGEVWmGyynghtk...........VAVK

Chain	Residue	Details
A	LEU251-LYS273

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLRAANILV

Chain	Residue	Details
A	TYR360-VAL372

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP364

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU251
A	LYS273

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:8139546

Chain	Residue	Details
A	PTR394

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by CSK => ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:8139546, ECO:0000269|PubMed:8631775, ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	TYR505

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