1QO8

The structure of the open conformation of a flavocytochrome c3 fumarate reductase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008202	biological_process	steroid metabolic process
A	0010181	molecular_function	FMN binding
A	0016491	molecular_function	oxidoreductase activity
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding
D	0008202	biological_process	steroid metabolic process
D	0010181	molecular_function	FMN binding
D	0016491	molecular_function	oxidoreductase activity
D	0042597	cellular_component	periplasmic space
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM A 601

Chain	Residue
A	PHE53
A	ILE162
A	ASN333
A	ILE369
A	LEU433
A	HEM602
A	HOH2164
A	HOH2348
A	HOH2349
A	HOH2350
A	HOH2351
A	ASP54
A	HOH2352
A	SER58
A	HIS59
A	LEU60
A	CYS79
A	CYS82
A	HIS83
A	PHE85

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HEM A 602

Chain	Residue
A	HIS40
A	TYR43
A	LEU46
A	PRO55
A	HIS56
A	CYS65
A	CYS68
A	HIS69
A	LYS88
A	MET90
A	HEM601
A	HEM603

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM A 603

Chain	Residue
A	MET5
A	HIS9
A	SER17
A	GLN35
A	CYS36
A	CYS39
A	HIS40
A	HIS69
A	PRO91
A	ASP227
A	HEM602
A	HEM604
A	HOH2354
A	HOH2355

---

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM A 604

Chain	Residue
A	GLY6
A	HIS9
A	CYS15
A	CYS18
A	HIS19
A	GLU29
A	THR66
A	LYS70
A	GLY71
A	HIS72
A	HIS293
A	VAL467
A	ALA468
A	SER469
A	GLY470
A	HEM603
A	HOH2072
A	HOH2356

---

site_id	AC5
Number of Residues	42
Details	BINDING SITE FOR RESIDUE FAD A 605

Chain	Residue
A	HOH2110
A	HOH2189
A	HOH2191
A	HOH2216
A	HOH2339
A	HOH2357
A	HOH2358
A	VAL127
A	GLY128
A	GLY130
A	SER131
A	ALA132
A	ASP151
A	LYS152
A	GLY157
A	GLY158
A	ASN159
A	SER160
A	SER163
A	ALA164
A	GLY165
A	GLY166
A	SER271
A	ARG272
A	VAL273
A	ALA307
A	THR308
A	GLY309
A	SER331
A	ASN332
A	THR335
A	ASP339
A	HIS499
A	HIS500
A	GLY528
A	GLU529
A	ARG539
A	GLY542
A	ASN543
A	ALA544
A	ILE545
A	THR548

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEM D 601

Chain	Residue
D	ASP54
D	SER58
D	HIS59
D	LEU60
D	CYS79
D	CYS82
D	HIS83
D	PHE85
D	ILE162
D	ASN333
D	ILE369
D	LEU433
D	HEM602

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM D 602

Chain	Residue
D	HIS40
D	TYR43
D	LEU46
D	PRO55
D	HIS56
D	CYS65
D	CYS68
D	HIS69
D	PHE77
D	LYS88
D	MET90
D	LYS193
D	HEM601
D	HEM603

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HEM D 603

Chain	Residue
D	MET5
D	HIS9
D	SER17
D	CYS36
D	CYS39
D	HIS40
D	HIS69
D	PRO91
D	PHE92
D	LYS193
D	HEM602

---

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM D 604

Chain	Residue
D	MET5
D	GLY6
D	HIS9
D	CYS15
D	CYS18
D	HIS19
D	ILE23
D	VAL25
D	THR66
D	LYS70
D	GLY71
D	HIS72
D	GLU73
D	HIS293
D	HOH2146

---

site_id	BC1
Number of Residues	39
Details	BINDING SITE FOR RESIDUE FAD D 605

Chain	Residue
D	VAL127
D	GLY128
D	GLY130
D	SER131
D	ALA132
D	ASP151
D	LYS152
D	GLY157
D	GLY158
D	ASN159
D	SER160
D	SER163
D	ALA164
D	GLY165
D	SER271
D	ARG272
D	VAL273
D	ALA307
D	THR308
D	GLY309
D	SER331
D	ASN332
D	THR335
D	ASP339
D	HIS499
D	HIS500
D	GLY528
D	GLU529
D	ARG539
D	GLY542
D	ASN543
D	ALA544
D	ILE545
D	THR548
D	HOH2132
D	HOH2134
D	HOH2147
D	HOH2148
D	HOH2149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P0C278

Chain	Residue	Details
A	ARG397
D	ARG397

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: axial binding residue => ECO:0000269|PubMed:10581549, ECO:0007744|PDB:1QO8

Chain	Residue	Details
A	HIS9
D	HIS19
D	HIS40
D	HIS56
D	HIS59
D	HIS69
D	HIS72
D	HIS83
A	HIS19
A	HIS40
A	HIS56
A	HIS59
A	HIS69
A	HIS72
A	HIS83
D	HIS9

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: covalent => ECO:0000250|UniProtKB:P83223

Chain	Residue	Details
A	CYS15
D	CYS18
D	CYS36
D	CYS39
D	CYS65
D	CYS68
D	CYS79
D	CYS82
A	CYS18
A	CYS36
A	CYS39
A	CYS65
A	CYS68
A	CYS79
A	CYS82
D	CYS15

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P83223

Chain	Residue	Details
A	GLY71
D	GLY71
D	GLY165
D	ARG196
D	HIS360
D	SER372
D	GLU373
D	HIS499
D	ARG539
D	GLY542
A	GLY165
A	ARG196
A	HIS360
A	SER372
A	GLU373
A	HIS499
A	ARG539
A	GLY542

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:10581549, ECO:0007744|PDB:1QO8

Chain	Residue	Details
A	ALA132
A	ILE545
D	ALA132
D	ASP151
D	ASN159
D	SER160
D	GLY166
D	VAL273
D	ASP339
D	GLU529
D	ALA544
A	ASP151
D	ILE545
A	ASN159
A	SER160
A	GLY166
A	VAL273
A	ASP339
A	GLU529
A	ALA544

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1d4c

Chain	Residue	Details
A	HIS360
A	HIS499
A	ARG397
A	ARG539

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1d4c

Chain	Residue	Details
D	HIS360
D	HIS499
D	ARG397
D	ARG539

---