1QK1
CRYSTAL STRUCTURE OF HUMAN UBIQUITOUS MITOCHONDRIAL CREATINE KINASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004111 | molecular_function | creatine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| A | 0046314 | biological_process | phosphocreatine biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004111 | molecular_function | creatine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| B | 0046314 | biological_process | phosphocreatine biosynthetic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004111 | molecular_function | creatine kinase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| C | 0046314 | biological_process | phosphocreatine biosynthetic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004111 | molecular_function | creatine kinase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005743 | cellular_component | mitochondrial inner membrane |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| D | 0046314 | biological_process | phosphocreatine biosynthetic process |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004111 | molecular_function | creatine kinase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005743 | cellular_component | mitochondrial inner membrane |
| E | 0016301 | molecular_function | kinase activity |
| E | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| E | 0046314 | biological_process | phosphocreatine biosynthetic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004111 | molecular_function | creatine kinase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005743 | cellular_component | mitochondrial inner membrane |
| F | 0016301 | molecular_function | kinase activity |
| F | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| F | 0046314 | biological_process | phosphocreatine biosynthetic process |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004111 | molecular_function | creatine kinase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005743 | cellular_component | mitochondrial inner membrane |
| G | 0016301 | molecular_function | kinase activity |
| G | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| G | 0046314 | biological_process | phosphocreatine biosynthetic process |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004111 | molecular_function | creatine kinase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005743 | cellular_component | mitochondrial inner membrane |
| H | 0016301 | molecular_function | kinase activity |
| H | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| H | 0046314 | biological_process | phosphocreatine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 A 400 |
| Chain | Residue |
| A | ARG125 |
| A | ARG127 |
| A | ARG287 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 B 400 |
| Chain | Residue |
| B | ARG125 |
| B | ARG127 |
| B | ARG287 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 C 400 |
| Chain | Residue |
| C | ARG125 |
| C | ARG127 |
| C | ARG287 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 D 400 |
| Chain | Residue |
| D | ARG125 |
| D | ARG127 |
| D | ARG287 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 E 400 |
| Chain | Residue |
| E | ARG125 |
| E | ARG127 |
| E | ARG287 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 F 400 |
| Chain | Residue |
| F | ARG125 |
| F | ARG127 |
| F | ARG287 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 G 400 |
| Chain | Residue |
| G | ARG125 |
| G | ARG127 |
| G | ARG287 |
| G | ARG315 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 H 400 |
| Chain | Residue |
| H | ARG125 |
| H | ARG127 |
| H | ARG287 |
Functional Information from PROSITE/UniProt
| site_id | PS00112 |
| Number of Residues | 7 |
| Details | PHOSPHAGEN_KINASE Phosphagen kinase active site signature. CP.SNLGT |
| Chain | Residue | Details |
| A | CYS278-THR284 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00843 |
| Chain | Residue | Details |
| A | LYS161 | |
| B | THR325 | |
| B | ASN353 | |
| B | ILE368 | |
| C | LYS161 | |
| C | VAL224 | |
| C | ASN269 | |
| C | THR325 | |
| C | ASN353 | |
| C | ILE368 | |
| D | LYS161 | |
| A | VAL224 | |
| D | VAL224 | |
| D | ASN269 | |
| D | THR325 | |
| D | ASN353 | |
| D | ILE368 | |
| E | LYS161 | |
| E | VAL224 | |
| E | ASN269 | |
| E | THR325 | |
| E | ASN353 | |
| A | ASN269 | |
| E | ILE368 | |
| F | LYS161 | |
| F | VAL224 | |
| F | ASN269 | |
| F | THR325 | |
| F | ASN353 | |
| F | ILE368 | |
| G | LYS161 | |
| G | VAL224 | |
| G | ASN269 | |
| A | THR325 | |
| G | THR325 | |
| G | ASN353 | |
| G | ILE368 | |
| H | LYS161 | |
| H | VAL224 | |
| H | ASN269 | |
| H | THR325 | |
| H | ASN353 | |
| H | ILE368 | |
| A | ASN353 | |
| A | ILE368 | |
| B | LYS161 | |
| B | VAL224 | |
| B | ASN269 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P25809 |
| Chain | Residue | Details |
| A | ARG151 | |
| E | LEU196 | |
| F | ARG151 | |
| F | LEU196 | |
| G | ARG151 | |
| G | LEU196 | |
| H | ARG151 | |
| H | LEU196 | |
| A | LEU196 | |
| B | ARG151 | |
| B | LEU196 | |
| C | ARG151 | |
| C | LEU196 | |
| D | ARG151 | |
| D | LEU196 | |
| E | ARG151 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P00564 |
| Chain | Residue | Details |
| A | TRP213 | |
| B | TRP213 | |
| C | TRP213 | |
| D | TRP213 | |
| E | TRP213 | |
| F | TRP213 | |
| G | TRP213 | |
| H | TRP213 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P30275 |
| Chain | Residue | Details |
| A | VAL232 | |
| B | VAL232 | |
| C | VAL232 | |
| D | VAL232 | |
| E | VAL232 | |
| F | VAL232 | |
| G | VAL232 | |
| H | VAL232 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P07310 |
| Chain | Residue | Details |
| A | LEU355 | |
| B | LEU355 | |
| C | LEU355 | |
| D | LEU355 | |
| E | LEU355 | |
| F | LEU355 | |
| G | LEU355 | |
| H | LEU355 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bg0 |
| Chain | Residue | Details |
| A | ARG231 | |
| A | ARG287 | |
| A | ARG315 | |
| A | ARG127 | |
| A | GLU227 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bg0 |
| Chain | Residue | Details |
| B | ARG231 | |
| B | ARG287 | |
| B | ARG315 | |
| B | ARG127 | |
| B | GLU227 |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bg0 |
| Chain | Residue | Details |
| C | ARG231 | |
| C | ARG287 | |
| C | ARG315 | |
| C | ARG127 | |
| C | GLU227 |
| site_id | CSA4 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bg0 |
| Chain | Residue | Details |
| D | ARG231 | |
| D | ARG287 | |
| D | ARG315 | |
| D | ARG127 | |
| D | GLU227 |
| site_id | CSA5 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bg0 |
| Chain | Residue | Details |
| E | ARG231 | |
| E | ARG287 | |
| E | ARG315 | |
| E | ARG127 | |
| E | GLU227 |
| site_id | CSA6 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bg0 |
| Chain | Residue | Details |
| F | ARG231 | |
| F | ARG287 | |
| F | ARG315 | |
| F | ARG127 | |
| F | GLU227 |
| site_id | CSA7 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bg0 |
| Chain | Residue | Details |
| G | ARG231 | |
| G | ARG287 | |
| G | ARG315 | |
| G | ARG127 | |
| G | GLU227 |
| site_id | CSA8 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bg0 |
| Chain | Residue | Details |
| H | ARG231 | |
| H | ARG287 | |
| H | ARG315 | |
| H | ARG127 | |
| H | GLU227 |
