Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1QK1

CRYSTAL STRUCTURE OF HUMAN UBIQUITOUS MITOCHONDRIAL CREATINE KINASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004111	molecular_function	creatine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
A	0046314	biological_process	phosphocreatine biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004111	molecular_function	creatine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016740	molecular_function	transferase activity
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0046314	biological_process	phosphocreatine biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004111	molecular_function	creatine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016740	molecular_function	transferase activity
C	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
C	0046314	biological_process	phosphocreatine biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004111	molecular_function	creatine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0016020	cellular_component	membrane
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0016740	molecular_function	transferase activity
D	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
D	0046314	biological_process	phosphocreatine biosynthetic process
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0004111	molecular_function	creatine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016310	biological_process	phosphorylation
E	0016740	molecular_function	transferase activity
E	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
E	0046314	biological_process	phosphocreatine biosynthetic process
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0004111	molecular_function	creatine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0016020	cellular_component	membrane
F	0016301	molecular_function	kinase activity
F	0016310	biological_process	phosphorylation
F	0016740	molecular_function	transferase activity
F	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
F	0046314	biological_process	phosphocreatine biosynthetic process
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0004111	molecular_function	creatine kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0016020	cellular_component	membrane
G	0016301	molecular_function	kinase activity
G	0016310	biological_process	phosphorylation
G	0016740	molecular_function	transferase activity
G	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
G	0046314	biological_process	phosphocreatine biosynthetic process
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0004111	molecular_function	creatine kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0016020	cellular_component	membrane
H	0016301	molecular_function	kinase activity
H	0016310	biological_process	phosphorylation
H	0016740	molecular_function	transferase activity
H	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
H	0046314	biological_process	phosphocreatine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 400

Chain	Residue
A	ARG125
A	ARG127
A	ARG287

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 B 400

Chain	Residue
B	ARG125
B	ARG127
B	ARG287

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 C 400

Chain	Residue
C	ARG125
C	ARG127
C	ARG287

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 D 400

Chain	Residue
D	ARG125
D	ARG127
D	ARG287

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 E 400

Chain	Residue
E	ARG125
E	ARG127
E	ARG287

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 F 400

Chain	Residue
F	ARG125
F	ARG127
F	ARG287

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 G 400

Chain	Residue
G	ARG125
G	ARG127
G	ARG287
G	ARG315

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 H 400

Chain	Residue
H	ARG125
H	ARG127
H	ARG287

Functional Information from PROSITE/UniProt

site_id	PS00112
Number of Residues	7
Details	PHOSPHAGEN_KINASE Phosphagen kinase active site signature. CP.SNLGT

Chain	Residue	Details
A	CYS278-THR284

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00843

Chain	Residue	Details
A	LYS161
B	THR325
B	ASN353
B	ILE368
C	LYS161
C	VAL224
C	ASN269
C	THR325
C	ASN353
C	ILE368
D	LYS161
A	VAL224
D	VAL224
D	ASN269
D	THR325
D	ASN353
D	ILE368
E	LYS161
E	VAL224
E	ASN269
E	THR325
E	ASN353
A	ASN269
E	ILE368
F	LYS161
F	VAL224
F	ASN269
F	THR325
F	ASN353
F	ILE368
G	LYS161
G	VAL224
G	ASN269
A	THR325
G	THR325
G	ASN353
G	ILE368
H	LYS161
H	VAL224
H	ASN269
H	THR325
H	ASN353
H	ILE368
A	ASN353
A	ILE368
B	LYS161
B	VAL224
B	ASN269

site_id	SWS_FT_FI2
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P25809

Chain	Residue	Details
A	ARG151
E	LEU196
F	ARG151
F	LEU196
G	ARG151
G	LEU196
H	ARG151
H	LEU196
A	LEU196
B	ARG151
B	LEU196
C	ARG151
C	LEU196
D	ARG151
D	LEU196
E	ARG151

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P00564

Chain	Residue	Details
A	TRP213
B	TRP213
C	TRP213
D	TRP213
E	TRP213
F	TRP213
G	TRP213
H	TRP213

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P30275

Chain	Residue	Details
A	VAL232
B	VAL232
C	VAL232
D	VAL232
E	VAL232
F	VAL232
G	VAL232
H	VAL232

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P07310

Chain	Residue	Details
A	LEU355
B	LEU355
C	LEU355
D	LEU355
E	LEU355
F	LEU355
G	LEU355
H	LEU355

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)