Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1QG4

CANINE GDP-RAN F72Y MUTANT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000054	biological_process	ribosomal subunit export from nucleus
A	0000070	biological_process	mitotic sister chromatid segregation
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003924	molecular_function	GTPase activity
A	0005049	molecular_function	nuclear export signal receptor activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006606	biological_process	protein import into nucleus
A	0006611	biological_process	protein export from nucleus
A	0006913	biological_process	nucleocytoplasmic transport
A	0015031	biological_process	protein transport
A	0016442	cellular_component	RISC complex
A	0016787	molecular_function	hydrolase activity
A	0032991	cellular_component	protein-containing complex
A	0035281	biological_process	pre-miRNA export from nucleus
A	0042470	cellular_component	melanosome
A	0046039	biological_process	GTP metabolic process
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0046872	molecular_function	metal ion binding
A	0051301	biological_process	cell division
A	0061015	biological_process	snRNA import into nucleus
A	0070883	molecular_function	pre-miRNA binding
A	1905172	molecular_function	RISC complex binding
B	0000054	biological_process	ribosomal subunit export from nucleus
B	0000070	biological_process	mitotic sister chromatid segregation
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003924	molecular_function	GTPase activity
B	0005049	molecular_function	nuclear export signal receptor activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006606	biological_process	protein import into nucleus
B	0006611	biological_process	protein export from nucleus
B	0006913	biological_process	nucleocytoplasmic transport
B	0015031	biological_process	protein transport
B	0016442	cellular_component	RISC complex
B	0016787	molecular_function	hydrolase activity
B	0032991	cellular_component	protein-containing complex
B	0035281	biological_process	pre-miRNA export from nucleus
B	0042470	cellular_component	melanosome
B	0046039	biological_process	GTP metabolic process
B	0046827	biological_process	positive regulation of protein export from nucleus
B	0046872	molecular_function	metal ion binding
B	0051301	biological_process	cell division
B	0061015	biological_process	snRNA import into nucleus
B	0070883	molecular_function	pre-miRNA binding
B	1905172	molecular_function	RISC complex binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 221

Chain	Residue
A	THR24
A	GDP220
A	HOH314
A	HOH315
A	HOH316
A	HOH317

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 221

Chain	Residue
B	HOH308
B	HOH309
B	HOH310
B	THR24
B	GDP220
B	HOH307

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GDP A 220

Chain	Residue
A	GLY20
A	THR21
A	GLY22
A	LYS23
A	THR24
A	THR25
A	ASN122
A	LYS123
A	ASP125
A	SER150
A	ALA151
A	LYS152
A	MG221
A	HOH229
A	HOH247
A	HOH314
A	HOH315
A	HOH317

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GDP B 220

Chain	Residue
A	HOH286
B	GLY20
B	THR21
B	GLY22
B	LYS23
B	THR24
B	THR25
B	ASN122
B	LYS123
B	ASP125
B	SER150
B	ALA151
B	LYS152
B	MG221
B	HOH254
B	HOH307
B	HOH308
B	HOH310

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	328
Details	Domain: {"description":"Small GTPase Ran-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	32
Details	Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9533885","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9878368","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BXQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"Essential for GTP hydrolysis","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62827","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	5
Details	Region: {"description":"Interaction with RANBP1","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN69

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLN69

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLY20

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLY20

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)